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  • 块葛黄酮

    Tuberosin

    块葛黄酮
    产品编号 CFN95107
    CAS编号 41347-45-9
    分子式 = 分子量 C20H18O5 = 338.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Pueraria tuberose
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    块葛黄酮 CFN95107 41347-45-9 1mg QQ客服:1148253675
    块葛黄酮 CFN95107 41347-45-9 5mg QQ客服:1148253675
    块葛黄酮 CFN95107 41347-45-9 10mg QQ客服:1148253675
    块葛黄酮 CFN95107 41347-45-9 20mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Gyeongsang National University (Korea)
  • University of Madras (India)
  • Almansora University (Egypt)
  • Hamdard University (India)
  • Sapienza University of Rome (Italy)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Aarhus University (Denmark)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • The University of Newcastle (Australia)
  • Seoul National University (Korea)
  • Northeast Normal University Changchun (China)
  • FORTH-IMBB (Greece)
  • University of Virginia (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • New Zealand J. Forestry Sci.2014, 44:17
  • Nat Prod Commun.2014, 9(5):679-82
  • Ind Crops Prod.2015, 67:185-191
  • Tea Res. Ins. Of China2017, 1-12
  • Korean J of Food Science&Technology 2017, 49(2):146-150
  • Korean J. of Horticultural Sci. & Tech. 2017, 793-804
  • Plant J.2017, 90(3):535-546
  • BMC Complement Altern Med.2018, 18(1):303
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • Molecules.2018, 23(11):E2837
  • Molecules.2018, 23(7):E1659
  • Biofactors.2018, 44(2):168-179
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1126-1127:121743
  • Plant Physiol Biochem.2019, 144:355-364
  • J Adv Res.2019, 17:85-94
  • Molecules.2019, 24(24),4583
  • J Sep Sci.2019, 42(21):3352-3362
  • J Funct Foods2019, 54:449-456
  • J of Ana. Chem.2019, 74(11):1113-1121
  • Biomed Chromatogr.2019, 8:e4774
  • Oxid Med Cell Longev2019, 9056845:13
  • Biomolecules.2020, 10(2):E184
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • ...
  • 生物活性
    Description: Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner.
    Targets: α-glucosidase | NO | NOS
    In vitro:
    Nat Prod Res. 2014;28(23):2111-27.
    Pueraria tuberosa: a review on its phytochemical and therapeutic potential.[Pubmed: 24980468 ]
    Pueraria tuberosa (Willd.) DC is a perennial herb commonly known as 'vidarikanda', distributed throughout south east Asia.
    METHODS AND RESULTS:
    The plant's tuber is widely used in ethanomedicine as well as in traditional systems of medicine, particularly in ayurveda. It has been used in various ayurvedic formulations as restorative tonic, antiaging, spermatogenic and immune booster and has been recommended for the treatment of cardiovascular diseases, hepatosplenomegaly, fertility disorders, menopausal syndrome, sexual debility and spermatorrhoea. Numerous bioactive phytochemicals, mostly isoflavonoids such as puerarin, genistein, daidzein, tuberosin and so on have been identified in the tuber. In vivo and in vitro studies have provided the support against traditional demands of the tuber as spermatogenic, immune booster, aphrodisiac, anti-inflammatory, cardiotonic and brain tonic. However, further studies are required to define the active phytochemical compositions and to validate its clinical utilisation in the herbal formulations for human uses.
    CONCLUSIONS:
    This review provides an overview of traditional applications, current knowledge on the phytochemistry, pharmacology and toxicology of P. tuberosa. This review also provides plausible hypotheses about how various isoflavones particularly puerarin, genistein and daidzein, individually or collectively, may be responsible for the therapeutic potential against a wide range of ailments.
    J Inflamm (Lond). 2010 Sep 14;7:47.
    Antioxidant activity of tuberosin isolated from Pueraria tuberose Linn.[Pubmed: 20836891]
    Antioxidant activity of Pueraria tuberose DC, (PT) Leguminosae (Fabaceae) has already been reported by us and here an active compound has been isolated and its action on expression of iNOS protein has been explored by using LPS induced changes in attached rat peritoneal macrophage cell culture.
    METHODS AND RESULTS:
    The pure compound was isolated by column chromatography and its structure was characterized by spectral studies, which was identified as tuberosin (5 hydroxy 3,4,7,3',4' pentamethoxy flavone). Its antioxidant capacity was determined and compared with alcoholic extract as EC50 value for scavenging potential towards pre-generated monocation ABTS* radical, superoxide radicals, hydroxyl radicals, metal chelation property and on lipid peroxidation. Further, rat peritoneal macrophages were isolated, cultured and the attached macrophages were exposed to lipopolysaccharide (LPS) with different concentrations of tuberosin (pretreatment for 30 min). After 17 h the released NO content, in culture supernatant, was indirectly estimated as accumulated nitrite by Griess reagent. To understand the mechanism of action, the extent of expression of inducible nitric oxide synthase genes, the iNOS protein was assessed in macrophage lysate by using its antibody on western blot analysis. Tuberosin significantly scavenged all the species of FRs, described above and it also inhibited the LPS induced release of NO and amount of iNOS protein in macrophages. All the changes were significant and concentration dependent.
    CONCLUSIONS:
    Thus it could be suggested that tuberosin, is one of the active principles of Pueraria tuberose, which directly scavenges various species of Free radicals (FRs) and also inhibits LPS induced inflammatory changes in macrophages.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9551 mL 14.7754 mL 29.5508 mL 59.1017 mL 73.8771 mL
    5 mM 0.591 mL 2.9551 mL 5.9102 mL 11.8203 mL 14.7754 mL
    10 mM 0.2955 mL 1.4775 mL 2.9551 mL 5.9102 mL 7.3877 mL
    50 mM 0.0591 mL 0.2955 mL 0.591 mL 1.182 mL 1.4775 mL
    100 mM 0.0296 mL 0.1478 mL 0.2955 mL 0.591 mL 0.7388 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Phaseollidin hydrate; Phaseollidin hydrate CFN96054 76122-57-1 C20H22O5 = 342.4 5mg QQ客服:1413575084
    刺桐酚素; Cristacarpin CFN96024 74515-47-2 C21H22O5 = 354.4 5mg QQ客服:2932563308
    Orientanol A; Orientanol A CFN96166 190381-82-9 C21H24O7 = 388.4 5mg QQ客服:1413575084
    Barbacarpan; Barbacarpan CFN98069 213912-46-0 C20H18O4 = 322.4 5mg QQ客服:1413575084
    菜豆蛋白; Phaseollin CFN97946 13401-40-6 C20H18O4 = 322.4 5mg QQ客服:1148253675
    6a,11a-去氢块葛黄酮; Anhydrotuberosin CFN98647 41347-49-3 C20H16O4 = 320.3 5mg QQ客服:1413575084
    1-甲氧基菜豆素; 1-Methoxyphaseollidin CFN96878 65428-13-9 C21H22O5 = 354.40 5mg QQ客服:1148253675
    块葛黄酮; Tuberosin CFN95107 41347-45-9 C20H18O5 = 338.4 5mg QQ客服:2932563308
    羟基晚香玉酮; Hydroxytuberosone CFN97592 95456-43-2 C20H18O6 = 354.36 5mg QQ客服:3257982914
    Glyurallin A; Glyurallin A CFN89255 199331-36-7 C21H20O5 = 352.38 5mg QQ客服:2932563308

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