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  • 盐酸拓扑替康

    Topotecan hydrochloride

    盐酸拓扑替康
    产品编号 CFN90462
    CAS编号 119413-54-6
    分子式 = 分子量 C23H24ClN3O5 = 457.9
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Camptotheca acuminata Decne
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    盐酸拓扑替康 CFN90462 119413-54-6 10mg QQ客服:1413575084
    盐酸拓扑替康 CFN90462 119413-54-6 20mg QQ客服:1413575084
    盐酸拓扑替康 CFN90462 119413-54-6 50mg QQ客服:1413575084
    盐酸拓扑替康 CFN90462 119413-54-6 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade da Beira Interior (Germany)
  • Lodz University of Technology (Poland)
  • Universite Libre de Bruxelles (Belgium)
  • University of Wuerzburg (Germany)
  • St. Jude Children Research Hospital (USA)
  • Universitas Airlangga (Indonesia)
  • Texas A&M University (USA)
  • Chiang Mai University (Thailand)
  • Donald Danforth Plant Science Center (USA)
  • University of Limpopo (South Africa)
  • CSIRO - Agriculture Flagship (Australia)
  • Universidade de Franca (Brazil)
  • Universidade Federal de Santa Catarina (Brazil)
  • Universidad de La Salle (Mexico)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Microbiol.2022, 12:833233.
  • Journal of Third Military Medical University2018, 40(12):1073-1078
  • Appl Biochem Biotechnol.2020, 190(2):732-744
  • Antioxidants (Basel).2021, 10(9):1487.
  • Int J Mol Sci.2023, 24(17):13230.
  • J Traditional Thai Medical Res.2022, 8(1):pp1-14.
  • Pharmacol Rep.2017, 69(6):1224-1231
  • VNU Journal of Science2023, No. 20.
  • J Ethnopharmacol.2017, 196:75-83
  • Cell Physiol Biochem.2019, 52(6):1255-1266
  • The Journal of Animal & Plant Sciences.2020, 30(6):1366-1373
  • J Biotechnol.2020, 318:10-19.
  • Russian J Bioorganic Chemistry 2021, 47:1411-1417.
  • Foods.2022, 11(12):1773.
  • Chem Biol Interact.2020, 328:109200.
  • Molecules.2019, 24(21):E3834
  • FASEB J.2019, 33(8):9685-9694
  • Journal of Molecular Liquids2021, 334:116014.
  • ScientificWorldJournal.2022, 2022:4806889.
  • Phytother Res.2019, 33(4):1104-1113
  • Cell Metab.2020, S1550-4131(20)30002-4
  • Reprod Toxicol.2020, 96:1-10.
  • Molecules.2022, 27(13):4227.
  • ...
  • 生物活性
    Description: Topotecan hydrochloride, a topoisomerase I inhibitor, capable of inhibiting tumoral growth in animal models of retinoblastoma. Topotecan hydrochloride liposomes loaded CS/β-GP hydrogel could become a potential formulation for improving the antitumor efficacy of Topotecan hydrochloride.
    Targets: Topoisomerase I
    In vivo:
    Histol Histopathol. 2012 Apr;27(4):497-506.
    Topotecan hydrochloride effects on retinal vessels in newborn rats.[Pubmed: 22374727]
    A physiological system, i.e. rodent retina during vessel formation and hierarchical organization, was utilised for assaying antiangiogenic properties of Topotecan, a topoisomerase I inhibitor, capable of inhibiting tumoral growth in animal models of retinoblastoma. In particular we analysed possible differences in effectiveness and side effects among different drug dosages and ways of administration.
    METHODS AND RESULTS:
    In the present research only qualitative analyses were undertaken. After preliminary experiments, in which suckling animals subcutaneously treated with Topotecan dosages comprised between 9 and 3 mg/kg underwent high lethality and extremely severe systemic damages, 7 day-old rats were subcutaneously, intravenously or peribulbary injected with a single dose of 1 mg/kg; retinal vessels were visualized in retinal fluorangio-graphies taken 1 and 2 weeks after treatment. The most important and frequent alterations were found to affect radial vessels, which showed non-perfused and/or regionally mislocated segments, together with abnormal branching and enlargements in retinal periphery; persistence of capillary-free periarteriolar regions, non-vascularised regions and spots of extravascular FITC were also detected. Despite the high individual variability the alterations were substantially similar among the different ways of drug administration, while they appeared milder in 21 day-old rats, with respect to younger ones.
    CONCLUSIONS:
    The extensive vascular remodelling found after Topotecan administration, besides demonstrating the antiangiogenic properties of this chemioterapic drug, confirms the rodent retina as a highly valuable model system for studying angiogenesis modulation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1839 mL 10.9194 mL 21.8388 mL 43.6777 mL 54.5971 mL
    5 mM 0.4368 mL 2.1839 mL 4.3678 mL 8.7355 mL 10.9194 mL
    10 mM 0.2184 mL 1.0919 mL 2.1839 mL 4.3678 mL 5.4597 mL
    50 mM 0.0437 mL 0.2184 mL 0.4368 mL 0.8736 mL 1.0919 mL
    100 mM 0.0218 mL 0.1092 mL 0.2184 mL 0.4368 mL 0.546 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    盐酸拓扑替康; Topotecan hydrochloride CFN90462 119413-54-6 C23H24ClN3O5 = 457.9 20mg QQ客服:1413575084
    盐酸依立替康; Irinotecan hydrochloride CFN90886 100286-90-6 C33H39ClN4O6 = 623.2 20mg QQ客服:3257982914
    7-乙基喜树碱; 7-Ethylcamptothecin CFN90336 78287-27-1 C22H20N2O4 = 376.41 20mg QQ客服:2159513211
    7-乙基-10-羟基喜树碱; 7-Ethyl-10-Hydroxycamptothecin CFN90335 86639-52-3 C22H20N2O5 = 392.4 20mg QQ客服:2159513211
    9-甲氧基喜树碱; 9-Methoxycamptothecine CFN99729 39026-92-1 C21H18N2O5 = 378.38 20mg QQ客服:1457312923
    9-氨基喜树碱; 9-Aminocamptothecin CFN90309 91421-43-1 C20H17N3O4 = 363.37 20mg QQ客服:3257982914
    (S)-10-羟基喜树碱; (S)-10-Hydroxycamptothecin CFN99735 19685-09-7 C20H16N2O5 = 364.35 20mg QQ客服:2056216494
    10-甲氧基喜树碱; 10-Methoxycamptothecin CFN90157 19685-10-0 C21H18N2O5 = 378.38 5mg QQ客服:1457312923
    鲁比替康; Rubitecan CFN93013 91421-42-0 C20H15N3O6 = 393.35 5mg QQ客服:3257982914
    10-硝基喜树碱; 10-Nitro-camptothecin CFN90439 104195-61-1 C20H15N3O6 = 393.34 5mg QQ客服:2159513211

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