圆叶肿柄菊素D

Tirotundin

	产品编号	CFN98943
	CAS编号	56377-67-4
	分子式 = 分子量	C₁₉H₂₈O₆ = 352.4
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Sesquiterpenoids
	植物来源	The leave of Tithonia diversifolia
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产品名称	产品编号	CAS编号	包装	QQ客服
圆叶肿柄菊素D	CFN98943	56377-67-4	1mg	QQ客服：1413575084
圆叶肿柄菊素D	CFN98943	56377-67-4	5mg	QQ客服：1413575084
圆叶肿柄菊素D	CFN98943	56377-67-4	10mg	QQ客服：1413575084
圆叶肿柄菊素D	CFN98943	56377-67-4	20mg	QQ客服：1413575084

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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
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PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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ACS Nano. 2018 Apr 24;12(4): 3385-3396.
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Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
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Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

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Indian Institute of Science (India)

University of Hawaii Cancer Center (USA)

University of Brasilia (Brazil)

Chulalongkorn University (Thailand)

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Northeast Normal University Changchun (China)

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Description:

Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the activation of NF-kappa B, thereby, the synthesis of inflammatory mediators such as cytokines and chemokines is reduced.

Targets:

PPAR | NF-kB | COX

In vitro:

Planta Med. 1998 Oct;64(7):588-93.

Study of three sesquiterpene lactones from Tithonia diversifolia on their anti-inflammatory activity using the transcription factor NF-kappa B and enzymes of the arachidonic acid pathway as targets.[Pubmed: 9810261]

In Central America leaf extracts from the Asteraceae Tithonia diversifolia are used externally for the treatment of haematomas and wounds. Therefore, the main sesquiterpene lactones (Sls) of this species growing in Costa Rica, diversifolin (1), diversifolin methyl ether (2), and Tirotundin (3), were studied for their anti-inflammatory activity.
METHODS AND RESULTS:
We determined whether these compounds inhibit cyclooxygenase-I, phospholipase A2, or the transcription factor NF-kappa B. Here we show that these Sls do not influence the enzymes of the arachidonic acid pathway, but inhibit the activation of NF-kappa B. Thereby, the synthesis of inflammatory mediators such as cytokines and chemokines is reduced.
CONCLUSIONS:
Our results indicate that the inhibitory activity of compounds 1-3 is due to alkylation of cysteine residues, which are probably located in the DNA binding domain of NF-kappa B. The Sls were also studied for their antibacterial activity, but only Sl 1 was moderately active against Bacillus subtilis in the agar plate diffusion test.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
4'-Hydroxypiptocarphin A; 4'-Hydroxypiptocarphin A	CFN96811	103994-39-4	C₂₁H₂₆O₁₀ = 438.42	5mg	QQ客服：1457312923
13-O-Ethylpiptocarphol; 13-O-Ethylpiptocarphol	CFN89157	202522-40-5	C₁₇H₂₄O₇ = 340.37	5mg	QQ客服：2159513211
Piptocarphin F; Piptocarphin F	CFN89128	76215-53-7	C₂₁H₂₈O₈ = 408.44	5mg	QQ客服：2056216494
1-O-Ethylpiptocarphin F; 1-O-Ethylpiptocarphin F	CFN89114	142891-12-1	C₂₃H₃₂O₈ = 436.50	5mg	QQ客服：2159513211
3-O-甲基圆叶肿柄菊素F; 3-O-Methyltagitinin F	CFN99204	110382-37-1	C₂₀H₂₆O₆ = 362.4	5mg	QQ客服：2159513211
圆叶肿柄菊素D; Tirotundin	CFN98943	56377-67-4	C₁₉H₂₈O₆ = 352.4	5mg	QQ客服：215959384
3-O-甲基圆叶肿柄菊素D; 3-O-Methyltirotundin	CFN99038	1021945-29-8	C₂₀H₃₀O₆ = 366.5	5mg	QQ客服：3257982914
圆叶肿柄菊素A; Tagitinin A	CFN97012	59979-61-2	C₁₉H₂₈O₇ = 368.4	5mg	QQ客服：3257982914
1-乙酰基圆叶肿柄菊素A; 1-Acetyltagitinin A	CFN97030	60547-63-9	C₂₁H₃₀O₈ = 410.5	5mg	QQ客服：2056216494
8alpha-羟基硬毛钩藤内酯 ; 8alpha-Hydroxyhirsutinolide	CFN96809	1394156-45-6	C₁₅H₂₀O₆ = 296.31	5mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8377 mL	14.1884 mL	28.3768 mL	56.7537 mL	70.9421 mL
5 mM	0.5675 mL	2.8377 mL	5.6754 mL	11.3507 mL	14.1884 mL
10 mM	0.2838 mL	1.4188 mL	2.8377 mL	5.6754 mL	7.0942 mL
50 mM	0.0568 mL	0.2838 mL	0.5675 mL	1.1351 mL	1.4188 mL
100 mM	0.0284 mL	0.1419 mL	0.2838 mL	0.5675 mL	0.7094 mL