巴豆酰戈米辛 H

Tigloylgomisin H

	产品编号	CFN96618
	CAS编号	66069-55-4
	分子式 = 分子量	C₂₈H₃₆O₈ = 500.59
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Lignans
	植物来源	The fruits of Schisandra chinensis.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
巴豆酰戈米辛 H	CFN96618	66069-55-4	1mg	QQ客服：3257982914
巴豆酰戈米辛 H	CFN96618	66069-55-4	5mg	QQ客服：3257982914
巴豆酰戈米辛 H	CFN96618	66069-55-4	10mg	QQ客服：3257982914
巴豆酰戈米辛 H	CFN96618	66069-55-4	20mg	QQ客服：3257982914

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Institute of Tropical Disease Universitas Airlangga (Indonesia)

Universidad de La Salle (Mexico)

MTT Agrifood Research Finland (Finland)

Anna University (India)

Univerzita Karlova v Praze (Czech Republic)

Semmelweis Unicersity (Hungary)

University of Lodz (Poland)

University of Eastern Finland (Finland)

Uniwersytet Jagielloński w Krakowie (Poland)

Martin Luther University of Halle-Wittenberg (Germany)

University of Hertfordshire (United Kingdom)

Guangzhou Institutes of Biomedicine and Health (China)

Macau University of Science and Technology (China)

Julius Kühn-Institut (Germany)

More...

Description:

Tigloylgomisin H represents a potential liver cancer prevention agent, it can significantly induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells, it functions as a novel monofunctional inducer that specifically upregulates phase II enzymes through the Nrf2-ARE pathway.

Targets:

Nrf2 | ARE

In vitro:

Planta Med. 2009 Oct;75(12):1314-8.

Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2.[Pubmed: 19452436]

The upregulation of phase II detoxification genes is believed to play an important role in cancer prevention. The molecular mechanism underlying the changes in gene expression that accompany cancer prevention involves activation of the transcription factor, NF-E2-related factor 2 (Nrf2). In traditional medicine, the fruit of Schisandra chinensis Baill is used as a tonic, an anti-tussive and an anti-aging drug.
METHODS AND RESULTS:
In the current study, nine lignans were isolated from S. chinensis and tested for their ability to induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H (TGH) and angeloylgomisin H (AGH) significantly induced QR activity and exhibited a relatively high chemoprevention index (CI) (10.80 and 4.59, respectively) as compared to control. TGH also induced QR activity in BPrc1 mouse hepatocarcinoma cells as well, which are defective in aryl hydrocarbon nuclear translocator (Arnt). In HepG2 human hepatocarcinoma cells, TGH significantly activated gene expression mediated by the antioxidant response element (ARE), a key regulatory region in the promoters of detoxification enzymes, through the nuclear accumulation of Nrf2.
CONCLUSIONS:
The results of the current study suggest that TGH functions as a novel monofunctional inducer that specifically upregulates phase II enzymes through the Nrf2-ARE pathway. TGH thus represents a potential liver cancer prevention agent.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
五味子酯乙; Schisantherin B	CFN99924	58546-55-7	C₂₈H₃₄O₉ = 514.57	20mg	QQ客服：2159513211
五味子酯甲; Schisantherin A	CFN99925	58546-56-8	C₃₀H₃₂O₉ = 536.56	20mg	QQ客服：1457312923
戈米辛D; Gomisin D	CFN90122	60546-10-3	C₂₈H₃₄O₁₀ = 530.56	20mg	QQ客服：215959384
戈米辛 E; Gomisin E	CFN96725	72960-21-5	C₂₈H₃₄O₉ = 514.57	5mg	QQ客服：1457312923
戈米辛F; Gomisin F	CFN92719	62956-47-2	C₂₈H₃₄O₉ = 514.6	5mg	QQ客服：3257982914
戈米辛G; Gomisin G	CFN90123	62956-48-3	C₃₀H₃₂O₉ = 536.6	10mg	QQ客服：215959384
戈米辛H; Gomisin H	CFN94008	66056-20-0	C₂₃H₃₀O₇ = 418.5	10mg	QQ客服：215959384
巴豆酰戈米辛 H; Tigloylgomisin H	CFN96618	66069-55-4	C₂₈H₃₆O₈ = 500.59	5mg	QQ客服：215959384
苯甲酰戈米辛 H; Benzoylgomisin H	CFN96939	66056-23-3	C₃₀H₃₄O₈ = 522.59	5mg	QQ客服：1413575084
Schisphenin E ; Schisphenin E	CFN95223	1311376-52-9	C₂₄H₃₂O₇ = 432.5	5mg	QQ客服：3257982914

信息支持

公司简介
订购流程
付款方式
退换货政策

ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

联系方式

电机：027-84237783
传真：027-84254680
在线QQ: 1413575084
E-Mail：manager@chemfaces.com

湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房

ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9976 mL	9.9882 mL	19.9764 mL	39.9529 mL	49.9411 mL
5 mM	0.3995 mL	1.9976 mL	3.9953 mL	7.9906 mL	9.9882 mL
10 mM	0.1998 mL	0.9988 mL	1.9976 mL	3.9953 mL	4.9941 mL
50 mM	0.04 mL	0.1998 mL	0.3995 mL	0.7991 mL	0.9988 mL
100 mM	0.02 mL	0.0999 mL	0.1998 mL	0.3995 mL	0.4994 mL