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  • 3',5,5',7-四羟基-4',6-二甲氧基黄酮

    • 3',5,5',7-四羟基-4',6-二甲氧基黄酮

    3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone

    3',5,5',7-四羟基-4',6-二甲氧基黄酮
    		产品编号 CFN99369
    CAS编号 125537-92-0
    分子式 = 分子量 C17H14O8 = 346.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The aerial parts of Artemisia salsoloides
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3',5,5',7-四羟基-4',6-二甲氧基黄酮 CFN99369 125537-92-0 1mg QQ客服：1413575084
    3',5,5',7-四羟基-4',6-二甲氧基黄酮 CFN99369 125537-92-0 5mg QQ客服：1413575084
    3',5,5',7-四羟基-4',6-二甲氧基黄酮 CFN99369 125537-92-0 10mg QQ客服：1413575084
    3',5,5',7-四羟基-4',6-二甲氧基黄酮 CFN99369 125537-92-0 20mg QQ客服：1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Charles Sturt University (Denmark)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Biol Chem.2021, 297(6):101362.
  • Separations2021, 8(6),80.
  • Biol Pharm Bull.2021, 44(12):1891-1893.
  • J of Food Quality2020, 8851285.
  • BMC Complement Med Ther. 2020, 20(1):91.
  • Biofactors.2018, 44(2):168-179
  • Cell Biochem Funct.2018, 36(6):303-311
  • Toxins (Basel).2021, 13(12):898.
  • HortTechnology2016, 26(6):816-819
  • Pharmaceutics.2021, 13(11):1839.
  • Int Immunopharmacol.2023, 125:111175.
  • Int. J. Mol. Sci.2022, 23(14),7699;
  • Int J Mol Sci.2019, 20(16):E4015
  • Nutraceuticals2022, 2(3),150-161
  • Food Engineering Progress2019, 23(3)209-216
  • Nutrients.2019, 11(6):E1380
  • Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
  • Foods.2023, 12(12):2412.
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • Univerzita Karlova2021, 20.500.11956.
  • Environ Toxicol.2023, 23929.
  • Molecules.2021, 26(18):5665.
  • Nutrients.2021, 13(10):3414.
  • ...
    • 生物活性
    Description: 5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it shows considerably activity against HIV-1 reverse transcriptase. It exhibits cytotoxic activity against P-388 cell lines, it can inhibit DNA topoisomerase IIα activity, which may be responsible for the observed cytotoxicity.
    Targets: HIV | Topoisomerase
    In vitro:
    Fitoterapia. 2012 Mar;83(2):368-72.
    DNA topoisomerase IIα inhibitory and anti-HIV-1 flavones from leaves and twigs of Gardenia carinata.[Pubmed: 22155186 ]

    METHODS AND RESULTS:
    Four new flavones, 5,2'-dihydroxy-7,3',4',5'-tetramethoxyflavone (1), 5,2',5'-trihydroxy-7,3',4'-trimethoxyflavone (2), 5,7,2',5'-tetrahydroxy-6,3',4'-trimethoxyflavone (3) and 5,2',5'-trihydroxy-6,7,3',4'-tetramethoxyflavone (4), along with the known 5,3'-dihydroxy-6,7,4',5'-tetramethoxyflavone (5), 5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone (3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone,6), syringaldehyde, vanillic acid and scopoletin were isolated from the leaves and twigs of Gardenia carinata (Rubiaceae). Their structures were determined by spectroscopic methods. Flavone 2 exhibited cytotoxic activity against P-388 and MCF-7 cell lines, while 3, 5 and 6 were active only in P-388 cell line. All active compounds were found to inhibit DNA topoisomerase IIα activity, which may be responsible for the observed cytotoxicity.
    CONCLUSIONS:
    Flavones 1-3, 5 and 6 also exhibited anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system; 2 was most potent. Only flavones 1 and 6 showed considerably activity against HIV-1 reverse transcriptase.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8877 mL 14.4383 mL 28.8767 mL 57.7534 mL 72.1917 mL
    5 mM 0.5775 mL 2.8877 mL 5.7753 mL 11.5507 mL 14.4383 mL
    10 mM 0.2888 mL 1.4438 mL 2.8877 mL 5.7753 mL 7.2192 mL
    50 mM 0.0578 mL 0.2888 mL 0.5775 mL 1.1551 mL 1.4438 mL
    100 mM 0.0289 mL 0.1444 mL 0.2888 mL 0.5775 mL 0.7219 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    苜蓿素; Tricin CFN98841 520-32-1 C17H14O7 = 330.3 10mg QQ客服：215959384
    4',5-二羟基-3',5',6,7-四甲氧基黄酮; 4',5-Dihydroxy-3',5',6,7-tetramethoxyflavone CFN97322 83133-17-9 C19H18O8 = 374.4 5mg QQ客服：1457312923
    5,3'-二羟基-6,7,4',5'-四甲氧基黄酮; 3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone CFN99214 111537-41-8 C19H18O8 = 374.4 5mg QQ客服：215959384
    5,7-二羟基-3',4',5'-三甲氧基黄酮; 5,7-Dihydroxy-3',4',5'-trimethoxyflavone CFN96493 18103-42-9 C18H16O7 = 344.32 5mg QQ客服：2056216494
    伞房花耳草素; Corymbosin CFN96498 18103-41-8 C19H18O7 = 358.34 5mg QQ客服：3257982914
    奇蒿黄酮; Arteanoflavone CFN96510 68710-17-8 C19H18O8 = 374.35 5mg QQ客服：2056216494
    3',4',5,5',6,7-六甲氧基黄酮; 3',4',5,5',6,7-Hexamethoxyflavone CFN70332 29043-07-0 C21H22O8 = 402.4 5mg QQ客服：2159513211
    4'-羟基-3',5,5',6,7,8-六甲氧基黄酮; 4'-Hydroxy-3',5,5',6,7,8-hexamethoxyflavone CFN95407 85644-03-7 C21H22O9 = 418.4 5mg QQ客服：3257982914
    5'-甲氧基川陈皮素; 5'-Methoxynobiletin CFN91940 6965-36-2 C22H24O9 = 432.42 5mg QQ客服：2159513211
    粘毛黄芩素III; Viscidulin III CFN97488 92519-91-0 C17H14O8 = 346.3 20mg QQ客服：1457312923

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