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  • 细叶远志皂苷

    Tenuifolin

    细叶远志皂苷
    产品编号 CFN98157
    CAS编号 20183-47-5
    分子式 = 分子量 C36H56O12 = 680.37
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Triterpenoids
    植物来源 The roots of Polygala tenuifolia Willd.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    细叶远志皂苷 CFN98157 20183-47-5 10mg QQ客服:1413575084
    细叶远志皂苷 CFN98157 20183-47-5 20mg QQ客服:1413575084
    细叶远志皂苷 CFN98157 20183-47-5 50mg QQ客服:1413575084
    细叶远志皂苷 CFN98157 20183-47-5 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • John Innes Centre (United Kingdom)
  • University of Queensland (Australia)
  • Weizmann Institute of Science (Israel)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • University of Helsinki (Finland)
  • Technical University of Denmark (Denmark)
  • Universiti Malaysia Pahang (Malaysia)
  • Charles Sturt University (Denmark)
  • University of Beira Interior (Portugal)
  • Mendel University in Brno (Czech Republic)
  • Universidade de Franca (Brazil)
  • Complutense University of Madrid (Spain)
  • Universidade Federal de Santa Catarina (Brazil)
  • Colorado State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Exp Mol Med.2020, 52(4):629-642.
  • Toxicological Research2020, doi: 10.1007.
  • Int J Mol Sci.2022, 23(1):538.
  • Food Science&Tech. Res.2022, 28(2):123-132.
  • Preprints2022, 2022030063.
  • J Food Sci.2021, 86(9):3810-3823.
  • Daru.2022, 30(2):273-288.
  • Phytomedicine.2021, 2(82):153452
  • Front Pharmacol.2018, 9:236
  • Trop J Pharm Res.2023, 22(3):283-288.
  • Antioxidants.2022, 11(4), 67.
  • Plants2022, 11(3),294.
  • Phytomedicine.2019, 67:153159
  • Cell Physiol Biochem.2017, 44(4):1381-1395
  • J Nat Med.2018, 72(3):734-744
  • Chem Biol Interact.2018, 290:44-51
  • Molecules. 2013, 18(7):7376-88
  • Int Immunopharmacol. 2020, 83:106403.
  • Plants (Basel).2020, 9(11):1555.
  • Biomol Ther (Seoul).2019, 10.4062
  • Histol Histopathol.2022, 18518.
  • Clin Transl Med.2021, 11(5):e392.
  • Evid Based Complement Alternat Med.2022, 2022:1307173.
  • ...
  • 生物活性
    Description: Tenuifolin is one of the active constituents of HPS against the neurotoxicity induced by Aβ25-35 peptides in vitro and in vivo, it possesses neuroprotective effects against Aβ25-35-induced apoptosis in PC12 cells and significantly improves the cognitive deficits induced by the intrahippocampal injection of Aβ25-35 in mice.
    Targets: Beta Amyloid | AChR
    In vitro:
    Acta Physiol (Oxf). 2009 Aug;196(4):419-25.
    Tenuifolin, an extract derived from tenuigenin, inhibits amyloid-beta secretion in vitro.[Pubmed: 19208093]
    Previous studies have shown that tenuigenin, a crude extract of Polygala tenuifolia Willd. that is commonly used in traditional Chinese herbal medicine for memory loss, can reduce the secretion of Abeta from cultured cells. However, the mechanism underlying this effect and the active compound derived from tenuigenin is unknown. In this study, a purified component of tenuigenin, tenuifolin, was examined and revealed to be an effective compound in vitro.
    METHODS AND RESULTS:
    Abeta secretion from three sets of COS-7 cells, each carrying a plasmid expressing a different form of APP was examined following the treatment with tenuifolin. Initially, tenuifolin was determined to have no inherent toxicity to either the transfected or wild type cells at the effective concentrations. Cells were then treated with 0.5-2.0 microg mL(-1) tenuifolin for 12 h and their media were examined via an ELISA for Abeta1-40 and Abeta-42. We found that treatment with 2.0 microg mL(-1) tenuifolin significantly decreased Abeta secretion from COS-7 cells without altering the ratio of Abeta1-40 and Abeta-42. This effect is most probably due to inhibition of the beta-site APP cleaving enzyme as Abeta secretion was not inhibited from cells expressing the C99 fragment.
    CONCLUSIONS:
    Tenuifolin is an effective compound from tenuigenin. We believe that this finding should lead the way for future experiments to determine the exact mechanism for tenuifolin's effect on Abeta secretion.
    Molecules 2012, 17(3), 3524-3538
    Terpenoids as Potential Anti-Alzheimer’s Disease Therapeutics[Pubmed: 17033524]
    Alzheimer’s disease (AD) is one of the most well-known neurodegenerative diseases and explains 50–60% of dementia in patients. The prevalence rate of AD is positively correlated with age and AD affects ≥ 40% of those over 85 years old. The major AD therapeutics available on the market are acetylcholinesterase inhibitors, such as tacrine and donepezil. New therapeutic agents that can block the disease-inducing mechanisms are essential. Diverse efforts have been made to discover anti-AD agents from natural sources. In this review article, we describe some representative terpenoids such as ginsenosides, gingkolides, and canabinoids as potential anti-AD agents. These compounds exhibit promising in vitro and in vivo biological activities, but are still waiting clinical trials. Additionally, we also discuss some terpenoids including cornel iridoid glycoside, oleanolic acid, tenuifolin, cryptotanshinone, and ursolic acid, which are under investigation for their in vitro and in vivo animal studies.
    In vivo:
    Pharmacol Biochem Behav. 2015 Jan;128:14-22.
    Tenuifolin, a secondary saponin from hydrolysates of polygalasaponins, counteracts the neurotoxicity induced by Aβ25-35 peptides in vitro and in vivo.[Pubmed: 25444865]
    Alzheimer's disease (AD) is associated with damage to hippocampal neurons and declines in cognitive functions. The accumulation of amyloid peptides is regarded as a crucial event in the initiation of AD. The neurotoxicity induced by Aβ25-35 peptides was used to screen for cytoprotective factors in vitro, and the cognitive deficits induced by the injection of Aβ25-35 into the hippocampus were used to evaluate effect on learning and memory. Our previous study revealed that hydrolysate of polygalasaponins (HPS) clearly improve the cognitive deficits induced by the injection of Aβ25-35 in mice, but the potential active constituent of HPS remains unclear. The purposes of this study were to separate and purify the secondary saponins of HPS, screen for neuroprotective effects of the constituents in vitro, and to evaluate the effect of cognition in vivo.
    METHODS AND RESULTS:
    Various chromatographic methods were used to separate and purify the HPS. The neuroprotective effects were examined in Aβ25-35-damage-induced PC12 cells. The protective effect of tenuifolin on the cognitive impairments induced by Aβ25-35 injection was assessed using the Morris water maze and step-through passive avoidance tests. Tenuifolin and fallaxsaponin A were isolated from the HPS. Tenuifolin possessed neuroprotective effects against Aβ25-35-induced apoptosis in PC12 cells and significantly improved the cognitive deficits induced by the intrahippocampal injection of Aβ25-35 in mice.
    CONCLUSIONS:
    Thus, tenuifolin is one of the active constituents of HPS against the neurotoxicity induced by Aβ25-35 peptides in vitro and in vivo.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.4698 mL 7.3489 mL 14.6979 mL 29.3958 mL 36.7447 mL
    5 mM 0.294 mL 1.4698 mL 2.9396 mL 5.8792 mL 7.3489 mL
    10 mM 0.147 mL 0.7349 mL 1.4698 mL 2.9396 mL 3.6745 mL
    50 mM 0.0294 mL 0.147 mL 0.294 mL 0.5879 mL 0.7349 mL
    100 mM 0.0147 mL 0.0735 mL 0.147 mL 0.294 mL 0.3674 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    常春藤皂甙元-3-O-(2-O-乙酰基-α-L-吡喃阿拉伯糖甙); Hederagenin 3-O-(2-O-acetyl-alpha-L-arabinopyranoside) CFN95355 87562-05-8 C37H58O9 = 646.9 10mg QQ客服:1413575084
    α-常春藤皂苷; alpha-Hederin CFN98325 27013-91-8 C41H66O12 = 751.0 20mg QQ客服:2159513211
    Glycoside L-F2; Glycoside L-F2 CFN00446 243857-99-0 C41H66O13 = 766.96 5mg QQ客服:2056216494
    Bernardioside A; Bernardioside A CFN90986 121368-52-3 C36H58O11 = 666.84 5mg QQ客服:2056216494
    次皂甙元CP6; Prosapogenin CP6 CFN90392 72629-76-6 C46H74O16 = 882.50 5mg QQ客服:2056216494
    常春藤苷H; 灰毡毛忍冬次皂苷甲; Kalopanaxsaponin H CFN90430 128730-82-5 C47H76O17 = 913.09 5mg QQ客服:215959384
    白头翁皂苷E1; Pulchinenoside E1 CFN80305 146100-02-9 C53H86O22 = 1075.25 5mg QQ客服:1413575084
    川续断皂苷IX; Dipsacussaponin C CFN95353 152406-43-4 C64H104O30 = 1353.5 5mg QQ客服:215959384
    白头翁皂苷E2; Pulchinenoside E2 CFN80362 244202-36-6 C53H86O21 = 1059.24 5mg QQ客服:2159513211
    Dipsacobioside; Dipsacobioside CFN94827 123350-57-2 C41H66O12 = 750.96 5mg QQ客服:3257982914

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