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  • 蒲公英赛醇

    Taraxerol

    蒲公英赛醇
    产品编号 CFN99381
    CAS编号 127-22-0
    分子式 = 分子量 C30H50O = 426.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Taraxacum mongolicum Hand. Mazz.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    蒲公英赛醇 CFN99381 127-22-0 1mg QQ客服:1457312923
    蒲公英赛醇 CFN99381 127-22-0 5mg QQ客服:1457312923
    蒲公英赛醇 CFN99381 127-22-0 10mg QQ客服:1457312923
    蒲公英赛醇 CFN99381 127-22-0 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
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  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • Nutrients.2021, 13(12):4364.
  • Molecules.2015, 20(11):20014-30
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  • ...
  • 生物活性
    Description: Taraxerol can be used as a lipid biomarker for mangrove input to the SE Atlantic. Taraxerol has potent anti-inflammatory effects,it downregulates the expression of proinflammatory mediators in macrophages by interfering with the activation of TAK1 and Akt, thus preventing NF-κB activation. Taraxerol also has anti-cancer activity, it shows inhibitory effects on AGS cell growth through inducing G2/M arrest and promotion of cell apoptosis, taraxeryl acetate has less effect on cell cycle arrest and apoptosis of AGS cells than taraxerol.
    Targets: NO | PGE | TNF-α | IL Receptor | NF-kB | TGF-β/Smad | Akt
    In vitro:
    Appl Biochem Biotechnol. 2012 Oct;168(3):487-503.
    Production of triterpenoid anti-cancer compound taraxerol in Agrobacterium-transformed root cultures of butterfly pea (Clitoria ternatea L.).[Pubmed: 22843061]
    Independent transformed root somaclones (rhizoclones) of butterfly pea (Clitoria ternatea L.) were established using explant co-cultivation with Agrobacterium rhizogenes.
    METHODS AND RESULTS:
    Rhizoclones capable of sustained growth were maintained under low illumination in auxin-free agar-solidified MS medium through subcultures at periodic intervals. Integration of T(L)-DNA rolB gene in the transformed rhizoclone genome was verified by Southern blot hybridization, and the transcript expression of T(R)-DNA ags and man2 genes was ascertained by reverse transcription polymerase chain reaction analysis. The major compound isolated and purified from the transformed root extracts was identified as the pentacyclic triterpenoid compound Taraxerol using IR, (1)H-NMR, and (13)C-NMR spectroscopy. The Taraxerol yield in cultured hairy roots, as quantified by HPTLC analysis, was up to 4-fold on dry weight basis compared to that in natural roots. Scanning of bands from cultured transformed roots and natural roots gave super-imposable spectra with standard Taraxerol, suggesting a remarkable homology in composition.
    CONCLUSIONS:
    To date, this is the first report claiming production of the cancer therapeutic phytochemical Taraxerol in genetically transformed root cultures as a viable alternative to in vivo roots of naturally occurring plant species.
    Geochim. Cosmochim. Ac., 2004, 68(3): 411-22.
    Taraxerol and Rhizophora pollen as proxies for tracking past mangrove ecosystems 1 1 Associate editor: R. Summons[Reference: WebLink]

    METHODS AND RESULTS:
    Angola Basin and Cape Basin (southeast Atlantic) surface sediments and sediment cores show that maxima in the abundance of taraxerol (relative to other land-derived lipids) covary with maxima in the relative abundance of pollen from the mangrove tree genus Rhizophora and that in the surface sediments offshore maxima in the relative abundance of taraxerol occur at latitudes with abundant coastal mangrove forests. Together with the observation that Rhizophora mangle and Rhizophora racemosa leaves are extraordinarily rich in taraxerol, this strongly indicates that taraxerol can be used as a lipid biomarker for mangrove input to the SE Atlantic. The proxy-environment relations for taraxerol and Rhizophora pollen down-core show that increased taraxerol and Rhizophora pollen abundances occur during transgressions and periods with a humid climate. These environmental changes modify the coastal erosion and sedimentation patterns, enhancing the extent of the mangrove ecosystem and/or the transport of mangrove organic matter offshore.
    CONCLUSIONS:
    Analyses of mid-Pleistocene sediments show that interruption of the pattern of taraxerol maxima during precession minima occurs almost only during periods of low obliquity. This demonstrates the complex environmental response of the interaction between precession-related humidity cycles and obliquity-related sea-level changes on mangrove input.
    Cell J . 2017 Oct;19(3):512-519.
    Taraxerol Induces Cell Apoptosis through A Mitochondria-Mediated Pathway in HeLa Cells[Pubmed: 28836414]
    Abstract Objectives: Taraxerol acetate has potent anti-cancer effects via the induction of apoptosis, autophagy, cell cycle arrest, and inhibition of cell migration. However, whether taraxerol induced apoptosis and its underlying mechanisms of action is not clear. In the present study, we assess the effects of taraxerol on the mitochondrial apoptotic pathway and determine the release of cytochrome c to the cytosol and activation of caspases. Materials and methods: In this experimental study, we mainly investigated the effect of taraxerol on HeLa cells. We tested cell viability by the MTT assay and morphologic changes, analyzed apoptosis by DAPI staining and flow cytometry. We also determined reactive oxygen species (ROS) and mitochondrial membrane potential (MMP) using a Microplate Reader. In addition, the apoptotic proteins were tested by Western blot. Results: Taraxerol enhanced ROS levels and attenuated the MMP (Δψm) in HeLa cells. Taraxerol induced apoptosis mainly via the mitochondrial pathway including the release of cytochrome c to the cytosol and activation of caspases 9 and 3, and anti-poly (ADPribose) polymerase (PARP). Taraxerol could induce the down-regulation of the anti-apoptotic protein Bcl-2 and up-regulation of pro-apoptotic protein Bax. It suppressed the PI3K/ Akt signaling pathway. Conclusions: These results demonstrated that taraxerol induced cell apoptosis through a mitochondria-mediated pathway in HeLa cells. Thus, taraxerol might be a potential anticervical cancer candidate. Keywords: Apoptosis; HeLa Cells; Mitochondria; Taraxerol.
    Cell J . 2017 Oct;19(3):512-519.
    Taraxerol Induces Cell Apoptosis through A Mitochondria-Mediated Pathway in HeLa Cells[Pubmed: 28836414]
    Abstract Objectives: Taraxerol acetate has potent anti-cancer effects via the induction of apoptosis, autophagy, cell cycle arrest, and inhibition of cell migration. However, whether taraxerol induced apoptosis and its underlying mechanisms of action is not clear. In the present study, we assess the effects of taraxerol on the mitochondrial apoptotic pathway and determine the release of cytochrome c to the cytosol and activation of caspases. Materials and methods: In this experimental study, we mainly investigated the effect of taraxerol on HeLa cells. We tested cell viability by the MTT assay and morphologic changes, analyzed apoptosis by DAPI staining and flow cytometry. We also determined reactive oxygen species (ROS) and mitochondrial membrane potential (MMP) using a Microplate Reader. In addition, the apoptotic proteins were tested by Western blot. Results: Taraxerol enhanced ROS levels and attenuated the MMP (Δψm) in HeLa cells. Taraxerol induced apoptosis mainly via the mitochondrial pathway including the release of cytochrome c to the cytosol and activation of caspases 9 and 3, and anti-poly (ADPribose) polymerase (PARP). Taraxerol could induce the down-regulation of the anti-apoptotic protein Bcl-2 and up-regulation of pro-apoptotic protein Bax. It suppressed the PI3K/ Akt signaling pathway. Conclusions: These results demonstrated that taraxerol induced cell apoptosis through a mitochondria-mediated pathway in HeLa cells. Thus, taraxerol might be a potential anticervical cancer candidate. Keywords: Apoptosis; HeLa Cells; Mitochondria; Taraxerol.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3436 mL 11.7178 mL 23.4357 mL 46.8713 mL 58.5892 mL
    5 mM 0.4687 mL 2.3436 mL 4.6871 mL 9.3743 mL 11.7178 mL
    10 mM 0.2344 mL 1.1718 mL 2.3436 mL 4.6871 mL 5.8589 mL
    50 mM 0.0469 mL 0.2344 mL 0.4687 mL 0.9374 mL 1.1718 mL
    100 mM 0.0234 mL 0.1172 mL 0.2344 mL 0.4687 mL 0.5859 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异蒲公英赛醇; Epitaraxerol CFN97789 20460-33-7 C30H50O = 426.73 5mg QQ客服:1413575084
    蒲公英赛醇; Taraxerol CFN99381 127-22-0 C30H50O = 426.7 5mg QQ客服:1413575084
    乙酰蒲公英萜醇; Taraxeryl acetate CFN98087 2189-80-2 C32H52O2 = 468.8 5mg QQ客服:1457312923
    蒲公英赛酮; Taraxerone CFN98821 514-07-8 C30H48O = 424.7 5mg QQ客服:2056216494
    杨梅萜二醇,蒲公英赛-14-烯-3beta,28-二醇; Myricadiol CFN99839 17884-88-7 C30H50O2 = 442.7 5mg QQ客服:1413575084
    14,17-表二氧基-28-去甲-15-蒲公英烯-2,3-二醇; 14,17-Epidioxy-28-nor-15-taraxerene-2,3-diol CFN97129 66107-60-6 C29H46O4 = 458.7 5mg QQ客服:1457312923

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