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  • 丹参二醇B

    Tanshindiol B

    丹参二醇B
    产品编号 CFN92146
    CAS编号 97465-70-8
    分子式 = 分子量 C18H16O5 = 312.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The roots of Salvia miltiorrhiza
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    丹参二醇B CFN92146 97465-70-8 1mg QQ客服:1457312923
    丹参二醇B CFN92146 97465-70-8 5mg QQ客服:1457312923
    丹参二醇B CFN92146 97465-70-8 10mg QQ客服:1457312923
    丹参二醇B CFN92146 97465-70-8 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade da Beira Interior (Germany)
  • University of Eastern Finland (Finland)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Almansora University (Egypt)
  • Texas A&M University (USA)
  • Cornell University (USA)
  • Max Rubner-Institut (MRI) (Germany)
  • National Hellenic Research Foundation (Greece)
  • Complutense University of Madrid (Spain)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • University of Fribourg (Switzerland)
  • University of Medicine and Pharmacy (Romania)
  • Univerzita Karlova v Praze (Czech Republic)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biomedicine & Pharmacotherapy2020, 125:109950
  • Molecules.2019, 24(1):E159
  • Microb Biotechnol.2021, 14(5):2009-2024.
  • Applied Biological Chem. 2020, 26(63).
  • Oxid Med Cell Longev.2022, 2022:5888636.
  • J Plant Biotechnol.2023, 50:070-075.
  • Academic J of Second Military Medical University2019, 40(1)
  • Int Immunopharmacol.2019, 71:361-371
  • Int. J. Mol. Sci.2022, 23(19), 11900.
  • HortTechnology2016, 26(6):816-819
  • Plants (Basel).2021, 10(5):951.
  • Appl. Sci. 2021, 11(22),10569
  • Int J Mol Sci.2022, 23(11):6172.
  • J Sep Sci.2020, 43(22):4148-4161.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2020, 1149:122123.
  • Theranostics.2023, 13(9):3103-3116.
  • Toxins (Basel).2022, 14(12):824.
  • Nutrients.2023, 15(13):2960.
  • Int J Mol Sci.2018, 19(9):E2528
  • Molecules.2016, 21(6)
  • Phytochem Anal.2021, 32(6):970-981.
  • Journal of Molecular Liquids2021, 334:116014.
  • Front Plant Sci.2022, 13:982771.
  • ...
  • 生物活性
    Description: Tanshindiol B possesses a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information for designing a new class of potent EZH2 inhibitors. It also possesses the anti-angiogenic activity,so it can be a promising candidate for angiogenesis inhibitors.
    Targets: EZH2 | VEGF
    In vitro:
    Bioorganic & Medicinal Chemistry Letters, 2014, 24(11):2486-2492.
    Biological evaluation of tanshindiols as EZH2 histone methyltransferase inhibitors.[Reference: WebLink]
    EZH2 is the core subunit of Polycomb repressive complex 2 catalyzing the methylation of histone H3 lysine-27 and closely involved in tumorigenesis.
    METHODS AND RESULTS:
    To discover small molecule inhibitors for EZH2 methyltransferase activity, we performed an inhibitor screen with catalytically active EZH2 protein complex and identified tanshindiols as EZH2 inhibitors. Tanshindiol B and Tanshindiol C potently inhibited the methyltransferase activity in in vitro enzymatic assay with IC50 values of 0.52 μM and 0.55 μM, respectively. Tanshindiol C exhibited growth inhibition of several cancer cells including Pfeiffer cell line, a diffuse large B cell lymphoma harboring EZH2 A677G activating mutation. Tanshindiol treatment in Pfeiffer cells significantly decreased the tri-methylated form of histone H3 lysine-27, a substrate of EZH2, as revealed by Western blot analysis and histone methylation ELISA. Based on enzyme kinetics and docking studies, we propose that tanshindiol-mediated inhibition of EZH2 activity is competitive for the substrate S-adenosylmethionine.
    CONCLUSIONS:
    Taken together, our findings strongly suggest that tanshindiols possess a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information for designing a new class of potent EZH2 inhibitors.
    Chinese Traditional Patent Medicine, 2014, 36(6):1146-1150.
    Tanshindiol B from Salvia przewalskii inhibits angiogenic activity.[Reference: WebLink]
    To study the effect of tanshindiol B from Salvia przewalskii Maxim. on angiogenic activity.
    CONCLUSIONS:
    Tanshindiol B was isolated from acetonic extract of S. przewalskii and purified by the silica gel column and Sephadex LH-20 column chromatography. MTT method was employed to explore the effect of tanshindiol B on the migration and the expression of human umbilical vein endothelial cells(HUVEC) and to measure the vascular endothelial growth factor(VEGF) level. The chicken chorioallantoic membrane(CAM) model was used for in vivo inhibition of angiogenic activity. Tanshindiol B could inhibit the proliferation and migration of HUVEC,angiogenesis on CAM,and the secrete of VEGF in a dose-dependent manner.
    CONCLUSIONS:
    Tanshindiol B possesses the anti-angiogenic activity,so it can be a promising candidate for angiogenesis inhibitors.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.202 mL 16.0102 mL 32.0205 mL 64.041 mL 80.0512 mL
    5 mM 0.6404 mL 3.202 mL 6.4041 mL 12.8082 mL 16.0102 mL
    10 mM 0.3202 mL 1.601 mL 3.202 mL 6.4041 mL 8.0051 mL
    50 mM 0.064 mL 0.3202 mL 0.6404 mL 1.2808 mL 1.601 mL
    100 mM 0.032 mL 0.1601 mL 0.3202 mL 0.6404 mL 0.8005 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    丹参二醇A; Tanshindiol A CFN92145 97411-46-6 C18H16O5 = 312.3 5mg QQ客服:2159513211
    丹参内酯; Tanshinlactone CFN99072 105351-70-0 C17H12O3 = 264.3 5mg QQ客服:1413575084
    甘西鼠尾新酮A; Neoprzewaquinone A CFN97087 630057-39-5 C36H28O6 = 556.6 5mg QQ客服:215959384
    3-羟基亚甲基丹参醌; 3-Hydroxymethylenetanshinquinone CFN90348 83145-47-5 C18H14O4 = 294.30 5mg QQ客服:1413575084
    1,2-二氢丹参醌; 1,2-Dihydrotanshinquinone CFN90333 77769-21-2 C18H14O3 = 278.3 5mg QQ客服:2159513211
    丹参酮I; Tanshinone I CFN98953 568-73-0 C18H12O3 = 276.3 20mg QQ客服:2159513211
    Isosalviamine A; Isosalviamine A CFN92645 878475-29-7 C19H13NO2 = 287.3 5mg QQ客服:2159513211
    Isosalviamine B; Isosalviamine B CFN92646 878475-30-0 C20H15NO2 = 301.3 5mg QQ客服:1457312923
    丹参醇B; Tanshinol B CFN90370 189290-30-0 C18H16O4 = 296.32 5mg QQ客服:1457312923
    紫丹参素C; Przewaquinone C CFN92021 96839-29-1 C18H16O4 = 296.3 5mg QQ客服:1457312923

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