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  • 圆叶肿柄菊素F

    Tagitinin F

    圆叶肿柄菊素F
    产品编号 CFN97011
    CAS编号 59979-57-6
    分子式 = 分子量 C19H24O6 = 348.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Tithonia diversifolia.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    圆叶肿柄菊素F CFN97011 59979-57-6 1mg QQ客服:1457312923
    圆叶肿柄菊素F CFN97011 59979-57-6 5mg QQ客服:1457312923
    圆叶肿柄菊素F CFN97011 59979-57-6 10mg QQ客服:1457312923
    圆叶肿柄菊素F CFN97011 59979-57-6 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Kyushu University (Japan)
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  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Immunol.2020, 11:598556.
  • Pharmaceutical Chemistry Journal2019, 52(12):986-991
  • J Cell Biochem.2022, 123(7):1222-1236.
  • Heinrich Heine University Dusseldorf2021, 62203.
  • Food Sci Biotechnol.2021, 30(2):217-226.
  • Acta horticulturae2017, 1158:257-268
  • Molecules.2019, 24(9):E1719
  • Research on Crops.2017, 18(2)
  • J Mass Spectrom.2022, 57(2):e4810.
  • Nutrients.2017, 10(1)
  • Pharmacological Reports2020, 1-9
  • Int J Mol Sci.2021, 22(21):11836.
  • Phytomedicine.2023, 117:154929.
  • South African Journal of Botany2021, 142:114-123.
  • Horticulture Research2022, uhac276.
  • Mol Med Rep.2014, 9(5):1653-9
  • Food Funct.2020, 11(2):1322-1333.
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • J Nat Med.2020, 74(1):65-75
  • Int J Mol Sci.2019, 20(23):E6071
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • Integr Cancer Ther.2018, 17(3):832-843
  • J Am Soc Mass Spectrom.2021, 32(9):2451-2462.
  • ...
  • 生物活性
    Description: Tagitinin F possesses antileukemic activity; it also shows in vitro leishmanicidal activities against Leishmania braziliensis promastigotes and amastigotes.
    Targets: Antifection
    In vitro:
    Molecules. 2014 May 14;19(5):6070-9.
    In vitro leishmanicidal activities of sesquiterpene lactones from Tithonia diversifolia against Leishmania braziliensis promastigotes and amastigotes.[Pubmed: 24830711 ]
    Natural compounds represent a rich and promising source of novel, biologically active chemical entities for treating leishmaniasis. Sesquiterpene lactones are a recognized class of terpenoids with a wide spectrum of biological activities, including activity against Leishmania spp.
    METHODS AND RESULTS:
    In this work, a sesquiterpene lactone-rich preparation-a leaf rinse extract (LRE) from Tithonia diversifolia-was tested against promastigote forms of L. braziliensis. The results revealed that the LRE is a rich source of potent leishmanicidal compounds, with an LD50 value 1.5 ± 0.50 µg·mL-1. Therefore, eight sesquiterpene lactones from the LRE were initially investigated against promastigote forms of L. braziliensis. One of them did not present any significant leishmanicidal effect (LD50 > 50 µg·mL-1). Another had a cytotoxic effect against macrophages (4.5 µg·mL-1). The five leishmanicidal compounds with the highest level of selectivity were further evaluated against intracellular parasites (amastigotes) using peritoneal macrophages. Tirotundin 3-O-methyl ether, tagitinin F, and a guaianolide reduced the internalization of parasites after 48 h, in comparison with the negative control.
    CONCLUSIONS:
    This is the first report on sesquiterpene lactones that have potent leishmanicidal effects on both developmental stages of L. braziliensis.
    Fitoterapia. 2012 Dec;83(8):1590-7.
    Three new sesquiterpenes from Tithonia diversifolia and their anti-hyperglycemic activity.[Pubmed: 22986291 ]

    METHODS AND RESULTS:
    Three new germacrane sesquiterpenes (1), (2), (3), along with eleven known sesquiterpenes, namely, tirotundin-3-O-methyl ether (4), deacetylvguiestin (5), 1β-hydroxydiversifolin-3-O-methyl ether (6), tagitinin C (7), 1β-hydroxytirotundin-3-O-methyl ether (8), 1β-hydroxytirotundin-1,3-O-dimethyl ether (9), Tagitinin F-3-O-methyl ether (10), Tagitinin F (11), tagitinin A (12), 3β-acetoxy-4α-hydroxyeduesm-11(13)-en-12-oic acid (13) and ilicic acid (14) were isolated from the aerial parts of Tithonia diversifolia. Their structures were established by spectroscopic analysis, while the relative configuration of compound 1 was confirmed by X-ray diffraction analysis. In addition, compounds 1-14 were evaluated in vitro for their anti-hyperglycemic activity by glucose uptake in 3T3-L1 adipocytes.
    CONCLUSIONS:
    It was found that 10μg/mL 1, 3, 6 and 8 could significantly increase glucose uptake without significant toxic effects.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8703 mL 14.3513 mL 28.7026 mL 57.4053 mL 71.7566 mL
    5 mM 0.5741 mL 2.8703 mL 5.7405 mL 11.4811 mL 14.3513 mL
    10 mM 0.287 mL 1.4351 mL 2.8703 mL 5.7405 mL 7.1757 mL
    50 mM 0.0574 mL 0.287 mL 0.5741 mL 1.1481 mL 1.4351 mL
    100 mM 0.0287 mL 0.1435 mL 0.287 mL 0.5741 mL 0.7176 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    圆叶肿柄菊素D; Tirotundin CFN98943 56377-67-4 C19H28O6 = 352.4 5mg QQ客服:215959384
    3-O-甲基圆叶肿柄菊素D; 3-O-Methyltirotundin CFN99038 1021945-29-8 C20H30O6 = 366.5 5mg QQ客服:1413575084
    圆叶肿柄菊素A; Tagitinin A CFN97012 59979-61-2 C19H28O7 = 368.4 5mg QQ客服:1413575084
    1-乙酰基圆叶肿柄菊素A; 1-Acetyltagitinin A CFN97030 60547-63-9 C21H30O8 = 410.5 5mg QQ客服:2056216494
    8alpha-羟基硬毛钩藤内酯 ; 8alpha-Hydroxyhirsutinolide CFN96809 1394156-45-6 C15H20O6 = 296.31 5mg QQ客服:1413575084
    8alpha-(2-甲基丙烯酰氧基)硬毛钩藤内酯 ; 8alpha-(2-Methylacryloyloxy)hirsutinolide CFN96807 188293-70-1 C19H24O7 = 364.39 5mg QQ客服:1457312923
    8alpha-(2-甲基丙烯酰氧基)硬毛钩藤内酯 13-O-乙酸酯; 8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate CFN96805 67667-71-4 C21H26O8 = 406.43 5mg QQ客服:1413575084
    8alpha-(2-甲基丙烯酰氧基)-1alpha-甲氧基硬毛钩藤内酯-13-O-乙酸酯; 8alpha-(2-Methylacryloyloxy)-1-O-methylhirsutinolide 13-O-acetate CFN96804 883872-71-7 C22H28O8 = 420.45 5mg QQ客服:3257982914
    8alpha-巴豆酰氧基硬毛钩藤内酯 13-O-乙酸酯 ; 8alpha-Tigloyloxyhirsutinolide 13-O-acetate CFN96806 83182-58-5 C22H28O8 = 420.45 5mg QQ客服:1413575084
    Diacetylpiptocarphol; Diacetylpiptocarphol CFN97859 103476-99-9 C19H24O9 = 396.39 5mg QQ客服:3257982914

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