| In vivo: |
| The Japanese journal of pharmacognosy 39(3), 238-242, 1985-09-20 | | Effect of Eleutherococcus senticosus and Its Components on Sex- and Learning-Behaviours and Tyrosine Hydroxylase Activities of Adrenal Gland and Hypothalamic Regions in Chronic Stressed Mice[Reference: WebLink] | Eleutherococcus senticosus and its components, syringin and Syringaresinol-di-O-glucoside, were studied for their effect on sex behaviours and on acquired conditioned reactions in mice exposed to chronic "hanging stress."
METHODS AND RESULTS:
Rectal temperature was recorded during exposure to the stress, and adrenal gland weight, tyrosine hydroxylase activity in adrenal gland and hypothalamic regions, and corticosterone content in adrenal gland and serum were measured 24 hr after the final exposure to stress. A water extract from Eleutherococcus senticosus and syringin were shown to protect mice from the stress-induced decreases in sex behaviors and in rectal temperature. Syringaresinol-di-O-glucoside protected the animals from the stress-induced decreases in sex behaviours and in rectal temperature, the stress-induced failure of retrieval of memory, and the stress-induced enlargement of adrenal gland.
CONCLUSIONS:
They have no effect however on the stress-induced increase in tyrosine hydroxylase activity in adrenal gland and hypothalamic regions, and on corticosterone contents in adrenal gland and serum. |
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