| Description: |
Swertianolin shows anti-acetylcholinesterase activity effects, it shows significant hepatoprotective effect in the liver damage model induced by alpha-naphthylisot hiocyanate. Swertianolin can scavenge superoxide and hydroxyl radicals with the studying method of the autoxidation of Pyrogallol and afenton. |
| Targets: |
AChR |
| In vitro: |
| Planta Med. 2004 Oct;70(10):1011-4. | | Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors.[Pubmed: 15490334 ] | In order to discover new acetylcholinesterase (AChE) inhibitors, different plant extracts were screened by a previously established TLC bioautographic method.
The methanol extract of Gentiana campestris leaves exhibited significant inhibition of AChE activity.
METHODS AND RESULTS:
A bioactivity-guided fractionation approach was undertaken to isolate the active components. Four xanthones, bellidin, bellidifolin, bellidin 8-O-beta-glucopyranoside (norswertianolin), and bellidifolin 8-O-beta-glucopyranoside (swertianolin), were found to be responsible for the anti-AChE activity effects. Bellidifolin showed similar activity to galanthamine in this enzyme assay. | | Journal of Liaoning Normal University, 2003 , 26 (2) :171-173. | | Voltammetric Behavior of Swertianolin and Its Scavenging to Free Radicals[Reference: WebLink] | The electrochemical behavior of swertianolin and its scavenging to free radicals have been studied.
METHODS AND RESULTS:
A irreversible adsorpted reduction peak involving two electrons and two protons has been obtained in the medium of phosphate buffer(pH 8.2). The peak potential was at -1.61V(vs.SCE).
CONCLUSIONS:
Swertianolin showed that it can scavenge superoxide and hydroxyl radicals with the studying method of the autoxidation of Pyrogallol and afenton. |
|
| In vivo: |
| J Ethnopharmacol. 2014 May 28;154(1):259-66. | | The hepatoprotective effect and chemical constituents of total iridoids and xanthones extracted from Swertia mussotii Franch.[Pubmed: 24746481 ] | Total iridoids and xanthones (TIXS) were extracted from Swertia mussotii Franch, one of the most important eight Tibetan medicines in China, which was recorded in the book of Jingzhu Bencao and used for clinical treatment of cholestatic hepatitis for many years. Our aim was to study the hepatoprotective effect and chemical constituents of the TIXS.
METHODS AND RESULTS:
Crude extracts were prepared using 90% ethanol, and individual fractions were collected following HPD-300 macroporous resin column chromatography. HPLC/MS was applied to qualitatively and quantitatively analyze the TIXS. Then, the alpha-naphthylisot hiocyanate-induced liver damage model was used to assess the hepatoprotective effect of the TIXS.
A total of 12 compounds were identified by the fingerprint chromatography of the TIXS, and swertiamarin and swertianolin were shown to be its two main components. Oral administration of the TIXS at a dose of 35, 70 or 140 mg kg(-1), swertiamarin at a dose of 20 mg kg(-1) or swertianolin at a dose of 20 mg kg(-1), for 7 days in mice significantly reduced the alpha-naphthylisot hiocyanate-induced levels of alanine aminotransferase, aspartate aminotransferase and the total and direct bilirubins, and increased the bile flow (P<0.01).
CONCLUSIONS:
These findings suggest that the TIXS exhibits significant hepatoprotective effect in the liver damage model induced by alpha-naphthylisot hiocyanate. Its active constituents include swertiamarin and swertianolin. |
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