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  • 苏齐内酯

    Suchilactone

    苏齐内酯
    产品编号 CFN95010
    CAS编号 50816-74-5
    分子式 = 分子量 C21H20O6 = 368.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The herbs of Haplophyllum pedicellatum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    苏齐内酯 CFN95010 50816-74-5 1mg QQ客服:3257982914
    苏齐内酯 CFN95010 50816-74-5 5mg QQ客服:3257982914
    苏齐内酯 CFN95010 50816-74-5 10mg QQ客服:3257982914
    苏齐内酯 CFN95010 50816-74-5 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Amity University (India)
  • Universiti Sains Malaysia (Malaysia)
  • Universitas islam negeri Jakarta (Indonesia)
  • University of East Anglia (United Kingdom)
  • Wroclaw Medical University (Poland)
  • Seoul National University of Science and Technology (Korea)
  • Universidade do Porto (Portugal)
  • University of Queensland (Australia)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • University of Eastern Finland (Finland)
  • The Australian National University (Australia)
  • Istanbul University (Turkey)
  • University of Padjajaran (Indonesia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules. 2013, 18(7):7376-88
  • British Jou. Med.&Med. Research2014, 1802-1811
  • Nat Prod Sci.2014, 20(3):182-190
  • Acta Physiologiae Plantarum2016, 38:7
  • Acta horticulturae2017, 1158:257-268
  • Current Pharmaceutical Analysis2017, 13(5)
  • J Pharm Biomed Anal.2017, 140:274-280
  • Preprints2017, 2017120176
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • Phytother Res.2018, 32(12):2551-2559
  • The Journal of Agromedicine and Medical Sciences2018, 4(1)
  • J Liq Chromatogr R T2018, 41(12):761-769
  • Biofactors.2018, 44(2):168-179
  • World J Mens Health.2019, 10.5534
  • Molecules.2019, 24(10):E1926
  • Molecules.2019, 24(4):E709
  • Environ Toxicol.2019, 34(4):513-520.
  • Ann Transl Med.2019, 7(23):731
  • Food Sci Nutr.2019, 8(1):246-256
  • Comput Biol Chem.2019, 83:107096
  • Plant Foods Hum Nutr.2020, 10.1007
  • Nutrients2020, 12(2):488
  • Food Res Int.2020, 128:108778
  • ...
  • 生物活性
    Description: Suchilactone may have the potential to be developed as a treatment of Alzheimer's Disease.
    Targets: Beta Amyloid
    In vivo:
    J Agric Food Chem. 2017 Apr 19;65(15):3133-3140.
    Protective Roles of Monsonia angustifolia and Its Active Compounds in Experimental Models of Alzheimer's Disease.[Pubmed: 28378593 ]
    Alzheimer's disease (AD), a progressive neurodegenerative disorder, is characterized by the accumulation of neurotoxic β-amyloid (Aβ) peptides, which consequently affects cognitive decline and memory impairment. Current research on AD treatment is actively focusing on the prevention of neurotoxic Aβ peptide accumulation. Monsonia angustifolia is reported to be consumed as an indigenous vegetable in Tanzania.
    METHODS AND RESULTS:
    In this study, we investigated the effect of the ethanol (EtOH) extract of M. angustifolia dried ground material on Aβ production and spatial learning ability as protection against AD. The formation of Aβ peptides was significantly reduced in HeLa cells stably transfected with the Swedish mutant form of β-amyloid precursor protein (APPsw) after treatment with a 60% EtOH extract of M. angustifolia. We next examined the cognitive-improving effects of the EtOH extract in vivo. Tg2576 mice were treated with extract for 6 months and subjected to Morris water maze and novel object recognition tests. The results showed that the 60% EtOH extract of M. angustifolia significantly ameliorated behavioral deficits of the AD transgenic mice and reduced the level of insoluble Aβ42 in the cerebral cortex and hippocampus. We further found that the 60% EtOH extract was effective for memory function recovery after shorter treatment (4 months). In addition, we isolated and identified several single compounds, justicidin A, 5-methoxyjusticidin A, chinensinaphthol, retrochinensinaphthol methyl ether, and suchilactone, from M. angustifolia and tested these compounds.
    CONCLUSIONS:
    Among them, justicidin A potently decreased the formation of Aβ in APPsw-transfected cells. These data suggest that the 60% EtOH extract of M. angustifolia has the potential to be developed as a treatment of AD. Furthermore, justicidin A may contribute, at least partially, to the Aβ alteration observed with the extract treatment.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7144 mL 13.5722 mL 27.1444 mL 54.2888 mL 67.861 mL
    5 mM 0.5429 mL 2.7144 mL 5.4289 mL 10.8578 mL 13.5722 mL
    10 mM 0.2714 mL 1.3572 mL 2.7144 mL 5.4289 mL 6.7861 mL
    50 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.0858 mL 1.3572 mL
    100 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.5429 mL 0.6786 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Pluviatolide; Pluviatolide CFN92059 28115-68-6 C20H20O6 = 356.4 5mg QQ客服:1148253675
    Kaerophyllin; Kaerophyllin CFN97234 75590-33-9 C21H20O6 = 368.4 5mg QQ客服:2932563308
    Meridinol; Meridinol CFN99313 120051-54-9 C20H18O7 = 370.4 5mg QQ客服:1413575084
    桧脂素, 洒维宁; Savinin CFN98786 493-95-8 C20H16O6 = 352.3 5mg QQ客服:1148253675
    苏齐内酯; Suchilactone CFN95010 50816-74-5 C21H20O6 = 368.4 5mg QQ客服:1148253675
    (E)-alpha-(3,4-Methylenedioxybenzylidene)-beta-(3,4,5-trimethoxybenzyl)-gamma-butyrolactone; Isonemerosin CFN95008 181524-79-8 C22H22O7 = 398.4 20mg QQ客服:215959384
    2,3-双(3,4-亚甲基二氧基苄基)丁-2-烯-4-内酯; 2,3-Di(3',4'-methylenedioxybenzyl)-2-buten-4-olide CFN97895 137809-97-3 C20H16O6 = 352.3 5mg QQ客服:215959384
    7-氧代扁柏脂素; 7-Oxohinokinin CFN99396 130837-92-2 C20H16O7 = 368.3 5mg QQ客服:2159513211
    Bis-5,5-nortrachelogenin; Bis-5,5-nortrachelogenin CFN96251 870480-56-1 C40H42O14 = 746.8 5mg QQ客服:215959384
    牛蒡酚A; Lappaol A CFN95067 62333-08-8 C30H32O9 = 536.6 10mg QQ客服:1413575084

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