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  • 大豆皂苷Ab

    Soyasaponin Ab

    大豆皂苷Ab
    产品编号 CFN90773
    CAS编号 118194-13-1
    分子式 = 分子量 C67H104O33 = 1437.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The seeds of Glycine max
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    大豆皂苷Ab CFN90773 118194-13-1 1mg QQ客服:215959384
    大豆皂苷Ab CFN90773 118194-13-1 5mg QQ客服:215959384
    大豆皂苷Ab CFN90773 118194-13-1 10mg QQ客服:215959384
    大豆皂苷Ab CFN90773 118194-13-1 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Griffith University (Australia)
  • Chulalongkorn University (Thailand)
  • University of Ioannina (Greece)
  • University of Hawaii Cancer Center (USA)
  • University of Medicine and Pharmacy (Romania)
  • Ateneo de Manila University (Philippines)
  • Universidade do Porto (Portugal)
  • University of Cincinnati (USA)
  • Universitas islam negeri Jakarta (Indonesia)
  • Harvard University (USA)
  • University of Wuerzburg (Germany)
  • University of Malaya (Malaysia)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • University of Queensland (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Biol Macromol.2020, 161:1230-1239.
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • Food Addit Contam Part A Chem Anal Control Expo Risk Assess.2020, 37(9):1437-1448.
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • Korean Journal of Plant Resources2021, 34(1):52-58.
  • BioResources J.2020, 15(3).
  • Daru.2022, 30(2):273-288.
  • Arch Biochem Biophys.2020, 687:108363.
  • Molecules.2021, 26(2):E255.
  • J Neuroinflammation.2020, 17(1):75.
  • Food Chem. 2020, 320:126530
  • Front Pharmacol.2022, 13:870553.
  • Biochem Biophys Res Commun.2019, 518(4):732-738
  • National Academy Science Letters2023, s40009.
  • J Pharm Biomed Anal2016, 118:183-194
  • Srinagarind Medical Journal2019, 34(1)
  • Curr Issues Mol Biol.2023, ;45(2):1601-1612.
  • J of Apicultural Research2020, 10.1080
  • Research Square2020, doi: 10.21203.
  • Food Chem.2019, 278:683-691
  • Data Science for Genomics2023, 107-128.
  • Chemistry of Plant Materials.2019, 215-222
  • Journal of functional foods2018, 171-182
  • ...
  • 生物活性
    Description: Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of soyasaponin Ab. Soyasaponin Ab has anti-inflammatory effects, it can inhibit colon shortening, myeloperoxidase activity, the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), and activation of the transcription factor nuclear factor-κB (NF-κB); soyasaponin Ab (1, 2, 5, and 10 μM) can inhibit the production of NO (IC50 = 1.6 ± 0.1 uM) and prosta. Soyasaponin Aa and Ab can markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes through the downregulation of the adipogenesis-related transcription factors PPARγ and C/EBPα in 3T3-L1 adipocytes. They also can prevent scopolamine-induced memory impairment in mice without the inhibition of acetylcholinesterase, exhibit memory-enhancing effects.
    Targets: NOS | NF-kB | COX | NO | PPAR | TLR | TNF-α | JNK | ERK | p38MAPK | Fatty Acid Synthase | cAMP
    In vitro:
    J. Agr. Food Chem., 2011, 59(24):13165-72.
    Soyasaponin Ab ameliorates colitis by inhibiting the binding of lipopolysaccharide (LPS) to Toll-like receptor (TLR)4 on macrophages.[Pubmed: 22060784 ]
    Many clinical studies have shown that daily intake of soybean [ Glycine max (L.) Merr., Fabacease] or its foods may reduce the risk of osteoporosis, heart attack, hyperlipidemia, coronary heart disease, cardiovascular and chronic renal diseases, and cancers, including prostate, colon, and breast cancers. Of the soy constituents, soyasaponins exhibit anti-aging, antioxidant, apoptotic, and anti-inflammatory effects. However, the anti-inflammatory effect of Soyasaponin Ab has not been thoroughly studied. Therefore, we investigated its anti-inflammatory effects in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitic mice and lipopolysaccharide (LPS)-stimulated peritoneal macrophages.
    METHODS AND RESULTS:
    Soyasaponin Ab inhibited colon shortening, myeloperoxidase activity, the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), and activation of the transcription factor nuclear factor-κB (NF-κB). Soyasaponin Ab (1, 2, 5, and 10 μM) inhibited the production of NO (IC(50) = 1.6 ± 0.1 μM) and prostaglandin E(2) (IC(50) = 2.0 ± 0.1 ng/mL), the expression of tumor necrosis factor (TNF)-α (IC(50) = 1.3 ± 0.1 ng/mL), interleukin (IL)-1β (IC(50) = 1.5 ± 0.1 pg/mL), and toll-like receptor (TLR)4, and the phosphorylation of interleukin-1 receptor-associated kinase (IRAK)-1 in LPS-stimulated peritoneal macrophages. Soyasaponin Ab weakly inhibited the phosphorylation of ERK, JNK, and p38. Soyasaponin Ab significantly reduced the binding of Alexa-Fluor-594-conjugated LPS to peritoneal macrophages. Soyasaponin Ab did not affect TLR4 expression or LPS-induced NF-κB activation in TLR4 siRNA-treated peritoneal macrophages (knockdown efficiency of TLR4 > 94%).
    CONCLUSIONS:
    On the basis of these findings, Soyasaponin Ab may ameliorate colitis by inhibiting the binding of LPS to TLR4 on macrophages.
    In vivo:
    J.Agr.Food Chem., 2014, 62(9):2062-8.
    Soyasaponins Ab and Bb prevent scopolamine-induced memory impairment in mice without the inhibition of acetylcholinesterase.[Pubmed: 24450802 ]
    Soy (Glycine max, family Leguminosae), which contains isoflavones and saponins as main constituents, is known to exhibit memory-enhancing effects.
    METHODS AND RESULTS:
    Therefore, to investigate the role of soyasaponins in memory impairments, we isolated Soyasaponin Ab (SA) and soyasaponin Bb (SB) from soybean and measured their protective effects against scopolamine-induced memory impairment in mice. SA and SB significantly prevented scopolamine-induced memory impairment in passive avoidance and Y-maze tasks. Compared to SA, SB rescued memory impairment more potently. Treatment with SB (10 mg/kg, p.o.) protected memory impairment in passive avoidance and Y-maze tasks to 97% (F = 68.10, P < 0.05) and 78% (F = 35.57, P < 0.05) of untreated normal control level, respectively. SA and SB (10 mg/kg) also rescued scopolamine-induced memory impairment in Morris water maze task (F = 14.51, P < 0.05). In addition, soyasaponins preserved brain-derived neurotrophic factor (BNDF) expression (F = 33.69, P < 0.05) and cAMP response element-binding (CREB) protein phosphorylation (F = 91.62, P < 0.05) in the hippocampus of scopolamine-treated mice. However, SA and SB did not inhibit acetylcholinesterase in vitro and ex vivo.
    CONCLUSIONS:
    On the basis of these findings, we suggest that soybean, particularly soyasaponins, may protect memory impairment by increasing BDNF expression and CREB phosphorylation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.6956 mL 3.478 mL 6.956 mL 13.9121 mL 17.3901 mL
    5 mM 0.1391 mL 0.6956 mL 1.3912 mL 2.7824 mL 3.478 mL
    10 mM 0.0696 mL 0.3478 mL 0.6956 mL 1.3912 mL 1.739 mL
    50 mM 0.0139 mL 0.0696 mL 0.1391 mL 0.2782 mL 0.3478 mL
    100 mM 0.007 mL 0.0348 mL 0.0696 mL 0.1391 mL 0.1739 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    大豆皂苷 III; Soyasaponin III CFN91596 55304-02-4 C42H68O14 = 796.99 5mg QQ客服:1457312923
    大豆皂苷II; Soyasaponin II CFN93159 55319-36-3 C47H76O17 = 913.1 5mg QQ客服:1413575084
    大豆皂苷Bb; Soyasaponin Bb CFN90456 51330-27-9 C48H78O18 = 943.12 20mg QQ客服:215959384
    大豆皂苷 Ba; Soyasaponin Ba CFN90722 114590-20-4 C48H78O19 = 959.1 20mg QQ客服:2159513211
    大豆皂苷Aa; Soyasaponin Aa CFN90455 117230-33-8 C64H100O31 = 1365.46 5mg QQ客服:1413575084
    大豆皂苷Ab; Soyasaponin Ab CFN90773 118194-13-1 C67H104O33 = 1437.6 5mg QQ客服:215959384
    大豆皂苷Ac; Soyasaponin Ac CFN90774 133882-74-3 C67H104O32 = 1421.6 5mg QQ客服:1457312923
    Pedunsaponin C ; Pedunsaponin C CFN80325 272120-53-3 C42H66O14 = 795.0 5mg QQ客服:215959384
    Pedunsaponin A; Pedunsaponin A CFN80329 250613-27-5 C42H66O15 = 811.0 5mg QQ客服:1413575084
    大豆皂苷Be甲酯; Soyasaponin Be methyl Ester CFN90777 N/A C49H78O18 = 955.2 5mg QQ客服:1413575084

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