Info: Read More
  • 中药标准品生产商,产品定制服务
  • 氧化槐果碱

    Oxysophocarpine

    氧化槐果碱
    产品编号 CFN98321
    CAS编号 26904-64-3
    分子式 = 分子量 C15H22N2O2 = 262.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Styphnolobium japonicum (L.) Schott.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    氧化槐果碱 CFN98321 26904-64-3 10mg QQ客服:3257982914
    氧化槐果碱 CFN98321 26904-64-3 20mg QQ客服:3257982914
    氧化槐果碱 CFN98321 26904-64-3 50mg QQ客服:3257982914
    氧化槐果碱 CFN98321 26904-64-3 100mg QQ客服:3257982914
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universite Libre de Bruxelles (Belgium)
  • Harvard University (USA)
  • Shanghai University of TCM (China)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • University of Medicine and Pharmacy (Romania)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • University of Maryland (USA)
  • Hamdard University (India)
  • Pennsylvania State University (USA)
  • Indian Institute of Science (India)
  • University of Ioannina (Greece)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Kyoto University (Japan)
  • University of Melbourne (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Pharmacol.2020, 11:683.
  • Br J Pharmacol.2016, 173(2):396-410
  • Antioxidants (Basel).2020, 9(4):284.
  • Evid Based Complement Alternat Med.2020, 2020:2584783.
  • Academic J of Second Military Medical University2018, 39(11)
  • Molecules.2021, 26(2):E255.
  • Nutr Res Pract.2023, 17(4):670-681.
  • J Pharmacol Sci.2021, 147(2):184-191.
  • Plant J.2021, 107(6):1711-1723.
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • Int Immunopharmacol.2019, 71:361-371
  • Chemistry of Natural Compounds2018, 54(3):572-576
  • J Pharmaceutical and Biomedical Analysis2022, 114631.
  • Appl. Sci. 2021, 11(22), 10552
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • Molecules.2018, 23(2)
  • Bioorg Med Chem.2020, 28(12):115553.
  • Molecules.2020, 25(23):5556.
  • J Sep Sci.2018, 41(9):1938-1946
  • Korean J Dent Mater2020, 47(2):63-70.
  • Food Res Int.2018, 106:909-919
  • In Vitro Cellular & Developmental Biology - Plant 2021, 57:874–882.
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • ...
  • 生物活性
    Description: Oxysophocarpine shows anti-inflammatory, neuroprotective, anticonvulsant, and anti-nociceptive effects, it also attenuates inflammatory pain by suppressing the levels of phosphorylation of extracellular signal-regulated kinase 1/2, cyclooxygenase-2, prostaglandin E2, tumor necrosis factor α, interleukin-1 beta and interleukin-6.
    Targets: ERK | COX | PGE | TNF-α | IL Receptor | Caspase | GABA Receptor | Bcl-2/Bax | P450 (e.g. CYP17)
    In vitro:
    Pharm Biol. 2014 Aug;52(8):1052-9.
    Neuroprotective effects of oxysophocarpine on neonatal rat primary cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion.[Pubmed: 24601951]
    Oxysophocarpine (OSC), a quinolizidine alkaloid extracted from leguminous plants of the genus Robinia, is traditionally used for various diseases including neuronal disorders. This study investigated the protective effects of Oxysophocarpine on neonatal rat primary-cultured hippocampal neurons were injured by oxygen-glucose deprivation and reperfusion (OGD/RP).
    METHODS AND RESULTS:
    Cultured hippocampal neurons were exposed to OGD for 2 h followed by a 24 h RP. Oxysophocarpine (1, 2, and 5 μmol/L) and nimodipine (Nim) (12 μmol/L) were added to the culture after OGD but before RP. The cultures of the control group were not exposed to OGD/RP. MTT and LDH assay were used to evaluate the protective effects of Oxysophocarpine. The IC50 of OSC was found to be 100 μmol/L. Treatment with Oxysophocarpine (1, 2, and 5 μmol/L) attenuated neuronal damage (p < 0.001), with evidence of increased cell viability (p < 0.001) and decreased cell morphologic impairment. Furthermore, Oxysophocarpine increased MMP (p < 0.001), but it inhibited [Ca(2+)]i (p < 0.001) elevation in a dose-dependent manner at OGD/RP. Oxysophocarpine (5 μmol/L) also decreased the expression of caspase-3 (p < 0.05) and caspase-12 (p < 0.05).
    CONCLUSIONS:
    The results suggested that Oxysophocarpine has significant neuroprotective effects that can be attributed to inhibiting endoplasmic reticulum (ER) stress-induced apoptosis.
    In vivo:
    Planta Med. 2015 Jul;81(10):791-7.
    Oxysophocarpine Ameliorates Carrageenan-induced Inflammatory Pain via Inhibiting Expressions of Prostaglandin E2 and Cytokines in Mice.[Pubmed: 26132856]
    Oxysophocarpine is an alkaloid extracted from Sophora alopecuroides.
    METHODS AND RESULTS:
    Mouse ear swelling tests and carrageenan-induced paw edema tests were used to investigate the effects of Oxysophocarpine on inflammatory pain in mice. Morphological changes on inflamed paw sections were measured by hematoxylin-eosin staining. Oxysophocarpine also significantly reduced the paw edema volume and improved mechanical allodynia threshold value on carrageenan-induced inflammatory pain, as well as relieved paw tissues inflammatory damage and reduced the numbers of neutrophils in mice. Oxysophocarpine significantly suppressed over-expression of cyclooxygenase-2, tumor necrosis factor α, interleukin-1 beta, interleukin-6 and prostaglandin E2, and inhibited the over-phosphorylation of extracellular signal-regulated kinase 1/2.
    CONCLUSIONS:
    Based on these findings we propose that Oxysophocarpine attenuates inflammatory pain by suppressing the levels of phosphorylation of extracellular signal-regulated kinase 1/2, cyclooxygenase-2, prostaglandin E2, tumor necrosis factor α, interleukin-1 beta and interleukin-6.
    Mol Med Rep. 2013 Jun;7(6):1819-25.
    Oxysophocarpine induces anti-nociception and increases the expression of GABAAα1 receptors in mice.[Pubmed: 23563643]
    Oxysophocarpine (OSC) is an alkaloid extracted from Siphocampylus verticillatus. The aim of this study was to investigate the anti-nociceptive effects of Oxysophocarpine through systemic and intracerebroventricular administration in mice. Moreover, to evaluate its effectiveness and mechanism of action, this study investigated whether Oxysophocarpine altered the expression of γ-aminobutyric acid type A α1 (GABAAα1) receptors in the central nervous system.
    METHODS AND RESULTS:
    Thermal and chemical behavioral models of nociception were used to assess the anti‑nociceptive action of Oxysophocarpine.Oxysophocarpine was administered intraperitoneally (i.p.) or intracerebroventricularly (i.c.v.). Results showed that Oxysophocarpine (80 mg/kg, i.p.) significantly increased the tail withdrawal threshold with a peak effect of 25.46% maximal possible effect (MPE) at 60 min (P﹤0.01). Additionally, Oxysophocarpine (80 mg/kg) increased the positive staining of GABAAα1 receptors in cells.
    CONCLUSIONS:
    In conclusion, Oxysophocarpine administration is suggested to have anti-nociceptive effects on the central and peripheral nervous systems. The involvement of GABAA receptors in the anti-nociceptive activity of Oxysophocarpine is currently being investigated.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.811 mL 19.0549 mL 38.1098 mL 76.2195 mL 95.2744 mL
    5 mM 0.7622 mL 3.811 mL 7.622 mL 15.2439 mL 19.0549 mL
    10 mM 0.3811 mL 1.9055 mL 3.811 mL 7.622 mL 9.5274 mL
    50 mM 0.0762 mL 0.3811 mL 0.7622 mL 1.5244 mL 1.9055 mL
    100 mM 0.0381 mL 0.1905 mL 0.3811 mL 0.7622 mL 0.9527 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    槐定碱; Allomatrine CFN90222 641-39-4 C15H24N2O = 248.36 20mg QQ客服:2159513211
    槐定碱; Sophoridine CFN97172 6882-68-4 C15H24N2O = 248.4 20mg QQ客服:1413575084
    氧化槐定碱; Oxysophoridine CFN90290 54809-74-4 C15H24N2O2 = 264.36 5mg QQ客服:215959384
    氧化槐果碱; Oxysophocarpine CFN98321 26904-64-3 C15H22N2O2 = 262.4 20mg QQ客服:215959384
    苦参碱; Matrine CFN98835 519-02-8 C15H24N2O = 248.4 20mg QQ客服:1413575084
    12,13-去氢苦参碱; Lemannine CFN92839 58480-54-9 C15H22N2O = 246.4 5mg QQ客服:1413575084
    新槐胺; Neosophoramine CFN98875 52932-74-8 C15H20N2O = 244.3 5mg QQ客服:1457312923
    槐果碱; Sophocarpine CFN99182 145572-44-7 C15H22N2O = 246.35 20mg QQ客服:1457312923
    氧化苦参碱; 苦参素; Oxymatrine CFN99805 16837-52-8 C15H24N2O2 = 264.4 20mg QQ客服:2056216494
    槐苦参醇,槐醇; (+)-Sophoranol CFN92840 3411-37-8 C15H24N2O2 = 264.4 5mg QQ客服:3257982914

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产