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  • 黄芩黄酮II

    Skullcapflavone II

    黄芩黄酮II
    产品编号 CFN92216
    CAS编号 55084-08-7
    分子式 = 分子量 C19H18O8 = 374.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The roots of Scutellaria baicalensis Georgi
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    黄芩黄酮II CFN92216 55084-08-7 1mg QQ客服:2159513211
    黄芩黄酮II CFN92216 55084-08-7 5mg QQ客服:2159513211
    黄芩黄酮II CFN92216 55084-08-7 10mg QQ客服:2159513211
    黄芩黄酮II CFN92216 55084-08-7 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • National Cancer Center Research Institute (Japan)
  • National Cancer Institute (USA)
  • Korea Institute of Oriental Medicine (Korea)
  • Universit?t Basel (Switzerland)
  • Chungnam National University (Korea)
  • S.N.D.T. Women's University (India)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • University of Madras (India)
  • The Institute of Cancer Research (United Kingdom)
  • Srinakharinwirot University (Thailand)
  • Mahatma Gandhi University (India)
  • Anna University (India)
  • University of Padjajaran (Indonesia)
  • University of Toronto (Canada)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Inflammation.2020, 43(5):1716-1728.
  • Nat Prod Commun.2018, 10.1177
  • Food and Chemical Toxicology2020, 111221
  • Int. J. Mol. Sci.2023, 24(20),15294.
  • Front Pharmacol.2021, 12:635510.
  • Int J Mol Sci.2022, 23(23):14826.
  • Phytother Res.2022, 10.1002:ptr.7592.
  • The Korea Journal of Herbology2019, 34(2):25-32
  • Metabolites.2023, 13(5):625.
  • Srinagarind Medical Journal2017, 32(1)
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • Neurotox Res.2022, 40(6):1937-1947.
  • Anal Chim Acta.2018, 1039:162-171
  • J Nat Prod.2017, 80(4):854-863
  • Molecules.2020, 25(11):2599.
  • Inflammation.2022, 45(6):2529-2543.
  • JOTCSA.2023, 10(4); 893-902.
  • ScientificWorldJournal.2022, 2022:4806889.
  • Plant Cell Tiss Org2017, 479-486
  • Molecules.2019, 24(24):E4536
  • Eur Rev Med Pharmacol Sci.2020, 24(9):5127-5139.
  • Food Sci Biotechnol.2023, 32(9):1215-1223.
  • Heliyon2020, 6(6):e04337.
  • ...
  • 生物活性
    Description: Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy in Korea. Skullcapflavone II may have therapeutic potential for the treatment of allergic asthma.
    Targets: TGF-β/Smad | COX
    In vitro:
    FASEB J . 2019 Feb;33(2):2026-2036.
    Skullcapflavone II inhibits osteoclastogenesis by regulating reactive oxygen species and attenuates the survival and resorption function of osteoclasts by modulating integrin signaling[Pubmed: 30216110]
    Abstract Many bone diseases, such as osteoporosis and rheumatoid arthritis, are attributed to an increase in osteoclast number or activity; therefore, control of osteoclasts has significant clinical implications. This study shows how skullcapflavone II (SFII), a flavonoid with anti-inflammatory activity, regulates osteoclast differentiation, survival, and function. SFII inhibited osteoclastogenesis with decreased activation of MAPKs, Src, and cAMP response element-binding protein (CREB), which have been known to be redox sensitive. SFII decreased reactive oxygen species by scavenging them or activating nuclear factor-erythroid 2-related factor 2 (Nrf2), and its effects were partially reversed by hydrogen peroxide cotreatment or Nrf2 deficiency. In addition, SFII attenuated survival, migration, and bone resorption, with a decrease in the expression of integrin β3, Src, and p130 Crk-associated substrate, and the activation of RhoA and Rac1 in differentiated osteoclasts. Furthermore, SFII inhibited osteoclast formation and bone loss in an inflammation- or ovariectomy-induced osteolytic mouse model. These findings suggest that SFII inhibits osteoclastogenesis through redox regulation of MAPKs, Src, and CREB and attenuates the survival and resorption function by modulating the integrin pathway in osteoclasts. SFII has therapeutic potential in the treatment and prevention of bone diseases caused by excessive osteoclast activity.-Lee, J., Son, H. S., Lee, H. I., Lee, G.-R., Jo, Y.-J., Hong, S.-E., Kim, N., Kwon, M., Kim, N. Y., Kim, H. J., Lee, Y. J., Seo, E. K., Jeong, W. Skullcapflavone II inhibits osteoclastogenesis by regulating reactive oxygen species and attenuates the survival and resorption function of osteoclasts by modulating integrin signaling.
    In vivo:
    Int Immunopharmacol. 2012 Apr;12(4):666-74.
    Skullcapflavone II inhibits ovalbumin-induced airway inflammation in a mouse model of asthma.[Pubmed: 22314230]
    Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy in Korea. Skullcapflavone II antagonized the bradykinin receptor more potently than any of the other flavonoids derived from this plant.
    METHODS AND RESULTS:
    Here, we were investigated its therapeutic effects in a mouse model of ovalbumin (OVA)-induced allergic asthma. Administration of skullcapflavone II significantly reduced airway hyperresponsiveness (AHR), airway eosinophilia, Th2 cytokine production, and increased transforming growth factor-β1 (TGF-β1) levels in bronchoalveolarlavage (BAL) fluids and lungs from OVA-sensitized and -challenged mice. Skullcapflavone II administration also significantly suppressed subepithelial collagen deposition and goblet cell hyperplasia, elevated Smad7 expression and suppressed pSmad2/3 levels.
    CONCLUSIONS:
    Collectively, these findings indicate that skullcapflavone II, a potential bradykinin antagonist, reduced the major pathophysiological features of allergic asthma, at least in part by acting on TGF-β1/Smad signaling pathways. Thus, skullcapflavone II may have therapeutic potential for the treatment of allergic asthma.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6709 mL 13.3547 mL 26.7094 mL 53.4188 mL 66.7735 mL
    5 mM 0.5342 mL 2.6709 mL 5.3419 mL 10.6838 mL 13.3547 mL
    10 mM 0.2671 mL 1.3355 mL 2.6709 mL 5.3419 mL 6.6774 mL
    50 mM 0.0534 mL 0.2671 mL 0.5342 mL 1.0684 mL 1.3355 mL
    100 mM 0.0267 mL 0.1335 mL 0.2671 mL 0.5342 mL 0.6677 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5'-甲氧基川陈皮素; 5'-Methoxynobiletin CFN91940 6965-36-2 C22H24O9 = 432.42 5mg QQ客服:2056216494
    粘毛黄芩素III; Viscidulin III CFN97488 92519-91-0 C17H14O8 = 346.3 20mg QQ客服:2056216494
    粘毛黄芩素III 四乙酸酯; Viscidulin III tetraacetate CFN97545 96684-81-0 C25H22O12 = 514.4 5mg QQ客服:1413575084
    粘毛黄芩素II; Viscidulin II CFN92214 92519-93-2 C17H14O7 = 330.3 5mg QQ客服:2159513211
    5,2',6'-三羟基-6,7,8-三甲氧基黄酮; 5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone CFN92215 98187-98-5 C18H16O8 = 360.3 5mg QQ客服:2159513211
    半枝莲种素; Rivularin CFN92217 70028-59-0 C18H16O7 = 344.3 5mg QQ客服:2056216494
    黄芩黄酮II; Skullcapflavone II CFN92216 55084-08-7 C19H18O8 = 374.4 10mg QQ客服:1413575084
    3',5,5',7-四羟基-4',6-二甲氧基黄酮; 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone CFN99369 125537-92-0 C17H14O8 = 346.3 5mg QQ客服:2159513211
    5,7,3'-三羟基-6,4',5'-三甲氧基黄酮; 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone CFN90939 78417-26-2 C18H16O8 = 360.3 5mg QQ客服:1457312923
    3'-Hydroxy-5,7,4',5'-Tetramethoxyflavone; 3'-Hydroxy-5,7,4',5'-Tetramethoxyflavone CFN95397 29976-51-0 C19H18O7 = 358.4 5mg QQ客服:2159513211

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