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  • β-谷甾醇

    Beta-Sitosterol

    β-谷甾醇
    产品编号 CFN99916
    CAS编号 83-46-5
    分子式 = 分子量 C29H50O = 414.69
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The herbs of Anemone cathayensis Kitag.
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    提供自定义包装
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    β-谷甾醇 CFN99916 83-46-5 10mg QQ客服:2056216494
    β-谷甾醇 CFN99916 83-46-5 20mg QQ客服:2056216494
    β-谷甾醇 CFN99916 83-46-5 50mg QQ客服:2056216494
    β-谷甾醇 CFN99916 83-46-5 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Agricultural Research Organization (ARO) (Israel)
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  • Periyar University (India)
  • University of Fribourg (Switzerland)
  • Aveiro University (Portugal)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Toxicological Research2020, doi: 10.1007.
  • Cell Signal.2022, 99:110433.
  • Cosmetics2021, 8(3),91.
  • Tokyo Pharmaceutical University2020, 500001431953.
  • Int J Mol Med.2020, 45(5):1514-1524.
  • Korean J. Medicinal Crop Sci.2022, 30(2):124-133
  • Molecules2022, 27(14),4462
  • World J Mens Health.2019, 10.5534
  • Molecules.2020 ,25(16):3697.
  • Journal of Functional Foods2022, 98:105271.
  • SRM Institute of Sci&Tech2022, 34(1): 32-37
  • Phytomedicine.2019, 56:48-56
  • Biochem Systematics and Ecology2017, 11-18
  • Oxid Med Cell Longev2019, 9056845:13
  • Plant J.2017, 90(3):535-546
  • BMC Pharmacol Toxicol.2018, 19(1):5
  • Bull. Natl. Mus. Nat. Sci.2021, 47(2),109-114.
  • Appl Microbiol Biotechnol.2018, 102(12):5105-5120
  • J Pharmaceutical and Biomedical Analysis2022, 114631.
  • Chin J Appl. Physiol.2019, 35(3):283-288
  • Microorganisms.2021, 9(12):2514.
  • J Food Biochem.2019, 43(9):e12970
  • Molecules.2020, 25(18):4283.
  • ...
  • 生物活性
    Description: Beta-Sitosterol is a novel plant-derived angiogenic factor which may have potential pharmaceutical applications for the management of chronic wounds. It has potent anti-inflammatory, anti-proliferation, and pro- apoptosis activities, it also possesses antipyretic activity, similar to acetylsalicylic acid.
    Targets: PARP | Bcl-2/Bax | Caspase | IAP
    In vitro:
    Biol Pharm Bull. 2007 Jul;30(7):1317-23.
    Beta-sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio.[Pubmed: 17603173]
    Beta-Sitosterol is the main dietary phytosterol found in plants and has been shown to inhibit proliferation and induce apoptosis in human solid tumors such as colon and breast cancers. However, the mechanism by which Beta-Sitosterol induces apoptosis is not completely understood in leukemic cells.
    METHODS AND RESULTS:
    This study investigated the mechanism of apoptosis induced by Beta-Sitosterol in human leukemic U937 cells. Beta-Sitosterol induced cytotoxicity and apoptosis in U937 cells in a concentration dependent manner, as measured by hemocytometer counts, fluorescence microscopy, agarose gel electrophoresis, and flow cytometry analysis. The increase in apoptosis induced by Beta-Sitosterol was associated with down-regulation of Bcl-2, degradation of poly-(ADP-ribose) polymerase (PARP) and phospholipase C (PLC)-gamma1 protein, and activation of caspase-3. Beta-Sitosterol induced apoptosis was not associated with changes in the expression of Bcl-xL, Bax, or inhibitor of apoptosis proteins (IAPs). z-DEVD-fmk, a caspase-3 specific inhibitor, blocked caspase-3 activation and PARP degradation, and significantly attenuated Beta-Sitosterol-induced apoptosis. This suggests that caspase-3 activation is partially essential for Beta-Sitosterol-induced apoptosis. Bcl-2 overexpression also significantly blocked caspase-3 activation and the decrease in PARP cleavage by Beta-Sitosterol, and effectively attenuated the apoptotic response to Beta-Sitosterol.
    CONCLUSIONS:
    These results show that Beta-Sitosterol potently induces apoptosis in U937 cells and that Beta-Sitosterol-induced apoptosis is related to the selective activation of caspase-3 and induction of Bax/Bcl-2 ratio.
    Angiogenesis. 1999;3(2):117-23.
    A novel angiogenic factor derived from Aloe vera gel: beta-sitosterol, a plant sterol.[Pubmed: 14517429]
    Aloe vera gel has a beneficial effect on wound healing. Because angiogenesis is an essential process in wound healing, we hypothesized that Aloe vera gel might contain potent angiogenic compounds.
    METHODS AND RESULTS:
    Here we demonstrate that Aloe vera gel and its extracts are angiogenic on the chorioallantoic membrane (CAM) of chick embryo. Out of the three compounds purified from the final fraction of Aloe vera gel, beta-sitosterol showed a potent angiogenic activity in the CAM assay. In the presence of heparin, beta-sitosterol stimulated neovascularization in the mouse Matrigel plug assay and the motility of human umbilical vein endothelial cells in an in vitro wound migration assay.
    CONCLUSIONS:
    Thus beta-sitosterol is a novel plant-derived angiogenic factor which may have potential pharmaceutical applications for the management of chronic wounds.
    Nutr Cancer . 2015;67(8):1214-20
    Beta-Sitosterol: A Promising but Orphan Nutraceutical to Fight Against Cancer[Pubmed: 26473555]
    All the currently available cancer therapeutic options are expensive but none of them are safe. However, traditional plant-derived medicines or compounds are relatively safe. One widely known such compound is beta-sitosterol (BS), a plant derived nutrient with anticancer properties against breast cancer, prostate cancer, colon cancer, lung cancer, stomach cancer, ovarian cancer, and leukemia. Studies have shown that BS interfere with multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation. Most of the studies are incomplete partly due to the fact that BS is relatively less potent. But the fact that it is generally considered as nontoxic, the opposite of all currently available cancer chemo-therapeutics, is missed by almost all research communities. To offset the lower efficacy of BS, designing BS delivery for "cancer cell specific" therapy hold huge potential. Delivery of BS through liposome is one of such demonstrations that has shown to be highly promising. But further research did not progress neither in the field of drug delivery of BS nor in the field on how BS mediated anticancer activities could be improved, thus making BS an orphan nutraceutical. Therefore, extensive research with BS as potent anticancer nutraceutical is highly recommended.
    In vivo:
    Planta Med. 1980 Jun;39(2):157-63.
    Anti-inflammatory and antipyretic activities of beta-sitosterol[Reference: WebLink]

    METHODS AND RESULTS:
    The anti-inflammatory and antipyretic activities of Beta-Sitosterol , isolated from the plant CYPERUS ROTUNDUS has been studied, employing carrageenin induced oedema, cotton pellet implantation and Brewer's yeast induced pyrexia in rats. Beta-Sitosterol was found to possess potent anti-inflammatory activity against both the tests, similar to hydrocortisone and oxyphenbutazone when administered intraperitoneally. Moreover, it was also orally effective against carrageenin induced oedema. The antiinflammatory activity of Beta-Sitosterol was independent of pituitary adrenal axis. Beta-Sitosterol also possessed antipyretic activity, similar to acetylsalicylic acid. However, it was devoid of analgesic activity against aconitine induced writhing in mice. Beta-Sitosterol showed a wide margin of safety since the approximate LD 50 was more than 3 g/kg i.p. in mice and minimum ulcerogenic dose was 600 mg/kg i.p. in rats.
    CONCLUSIONS:
    The presence of the anti-inflammatory and antipyretic activities with wide margin of safety, Beta-Sitosterol may be of therapeutic value.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4114 mL 12.0572 mL 24.1144 mL 48.2288 mL 60.286 mL
    5 mM 0.4823 mL 2.4114 mL 4.8229 mL 9.6458 mL 12.0572 mL
    10 mM 0.2411 mL 1.2057 mL 2.4114 mL 4.8229 mL 6.0286 mL
    50 mM 0.0482 mL 0.2411 mL 0.4823 mL 0.9646 mL 1.2057 mL
    100 mM 0.0241 mL 0.1206 mL 0.2411 mL 0.4823 mL 0.6029 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    豆甾-4-烯-3-酮; Sitostenone CFN99073 1058-61-3 C29H48O = 412.7 5mg QQ客服:1413575084
    豆甾-4,22,25-三烯-3-酮; Stigmasta-4,22,25-trien-3-one CFN97408 848669-09-0 C29H44O = 408.7 5mg QQ客服:215959384
    豆甾-4,22-二烯-3-酮; Stigmasta-4,22-dien-3-one CFN98934 55722-32-2 C29H46O = 410.7 5mg QQ客服:2159513211
    豆固酮; Stigmastadienone CFN91574 20817-72-5 C29H46O = 410.7 5mg QQ客服:1457312923
    豆甾醇; Stigmasterol CFN97326 83-48-7 C29H48O = 412.7 20mg QQ客服:1413575084
    β-谷甾醇; Beta-Sitosterol CFN99916 83-46-5 C29H50O = 414.69 20mg QQ客服:1457312923
    β-谷甾基十六烷酸酯,棕榈酸谷甾醇酯; Sitosteryl palmitate CFN98235 2308-85-2 C45H80O2 = 653.1 5mg QQ客服:1413575084
    豆甾-5,8-二烯-3-醇; Stigmasta-5,8-dien-3-ol CFN98959 570-72-9 C29H48O = 412.7 5mg QQ客服:215959384
    alpha-菠菜甾醇; alpha-Spinasterol CFN98748 481-18-5 C29H48O = 412.7 10mg QQ客服:1413575084
    alpha-菠菜甾醇乙酸酯; alpha-Spinasterol acetate CFN98692 4651-46-1 C31H50O2 = 454.7 5mg QQ客服:2056216494

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