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  • 清风藤碱

    Sinoacutine

    清风藤碱
    产品编号 CFN98640
    CAS编号 4090-18-0
    分子式 = 分子量 C19H21NO4 = 327.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Stephania epigaea Lo
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    清风藤碱 CFN98640 4090-18-0 1mg QQ客服:2159513211
    清风藤碱 CFN98640 4090-18-0 5mg QQ客服:2159513211
    清风藤碱 CFN98640 4090-18-0 10mg QQ客服:2159513211
    清风藤碱 CFN98640 4090-18-0 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Amity University (India)
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  • Technical University of Denmark (Denmark)
  • University of Padjajaran (Indonesia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytomedicine.2019, 62:152962
  • Tokyo Pharmaceutical University2020, 500001431953.
  • Kor. J. Pharmacogn.2016, 47(1):62-72
  • J Exp Bot.2016, 67(12):3777-88
  • Molecules.2021, 26(9):2802.
  • Appl. Sci.2022, 12(4), 2032.
  • J Microbiol Biotechnol.2022, 32(2):141-148.
  • Molecules.2021, 26(4):1084.
  • Food and Fermentation Industries2018, 44(371)
  • Molecules.2021, 26(4):817.
  • The Journal of Phytopharmacology2020, 9(1): 1-4
  • Molecules2022, 27(9):2992.
  • Enzyme Microb Technol.2022, 161:110111.
  • Plant J.2021, 107(6):1711-1723.
  • Kaohsiung J Med Sci.2023, 10.1002/kjm2.12764
  • Aquaculture2017, 481:94-102
  • GxABT2022, 2268.2:15515.
  • Cytotechnology.2017, 69(5):765-773
  • Pharmaceuticals (Basel).2021, 14(10):1046.
  • Chemistry of Plant Materials.2016, 33-46
  • Drug Dev Res.2020, doi: 10.1002
  • J Ethnopharmacol.2020, 260:112988.
  • J Biochem Mol Toxicol.2022, e23211.
  • ...
  • 生物活性
    Description: Sinoacutine has protective effects against hydrogen peroxide-induced cell injury.
    Targets: P450 (e.g. CYP17)
    In vitro:
    J Biol Chem. 2009 Sep 25;284(39):26758-67.
    Removal of substrate inhibition and increase in maximal velocity in the short chain dehydrogenase/reductase salutaridine reductase involved in morphine biosynthesis.[Pubmed: 19648114]

    METHODS AND RESULTS:
    Sinoacutine reductase (SalR, EC 1.1.1.248) catalyzes the stereospecific reduction of Sinoacutine to 7(S)-salutaridinol in the biosynthesis of morphine. In addition, a specific role in Sinoacutine binding by either hydrogen bond formation or hydrophobic interactions was assigned to each amino acid. Substrate docking also revealed an alternative mode for Sinoacutine binding, which could explain the strong substrate inhibition of Sinoacutine reductase. An alternate arrangement of Sinoacutine in the enzyme was corroborated by the effect of various amino acid substitutions on substrate inhibition. In most cases, the complete removal of substrate inhibition was accompanied by a substantial loss in enzyme activity. However, some mutations greatly reduced substrate inhibition while maintaining or even increasing the maximal velocity.
    CONCLUSIONS:
    Based on these results, a double mutant of Sinoacutine reductase was created that exhibited the complete absence of substrate inhibition and higher activity compared with wild-type Sinoacutine reductase.
    J Nat Prod. 2005 Jul;68(7):1128-30.
    Morphinane alkaloids with cell protective effects from Sinomenium acutum.[Pubmed: 16038566 ]

    METHODS AND RESULTS:
    One new morphinane alkaloid, sinomenine N-oxide (1), and one new natural occurring morphinane alkaloid, N-demethylsinomenine (2), together with six known alkaloids, 7,8-didehydro-4-hydroxy-3,7-dimethoxymorphinan-6-ol (3), sinomenine (4), Sinoacutine (5), N-norSinoacutine, acutumine, and acutumidine, were isolated from the stems of Sinomenium acutum. Their structures were elucidated on the basis of spectroscopic analysis and chemical methods.
    CONCLUSIONS:
    Compounds 2, 3, and 5 have protective effects against hydrogen peroxide-induced cell injury.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0544 mL 15.2718 mL 30.5437 mL 61.0874 mL 76.3592 mL
    5 mM 0.6109 mL 3.0544 mL 6.1087 mL 12.2175 mL 15.2718 mL
    10 mM 0.3054 mL 1.5272 mL 3.0544 mL 6.1087 mL 7.6359 mL
    50 mM 0.0611 mL 0.3054 mL 0.6109 mL 1.2217 mL 1.5272 mL
    100 mM 0.0305 mL 0.1527 mL 0.3054 mL 0.6109 mL 0.7636 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6-乙酰基二氢表千金藤默星碱; Dihydroepistephamiersine 6-acetate CFN98965 57361-74-7 C23H31NO7 = 433.5 5mg QQ客服:1413575084
    Stephavanine; Stephavanine CFN98425 33116-33-5 C26H27NO9 = 497.5 5mg QQ客服:215959384
    氧代表千金藤默星碱; Oxoepistephamiersine CFN98830 51804-68-3 C21H25NO7 = 403.4 5mg QQ客服:2056216494
    表千金藤默星碱; Epistephamiersine CFN98856 52389-15-8 C21H27NO6 = 389.5 5mg QQ客服:2159513211
    Periglaucine A; Periglaucine A CFN99040 1025023-04-4 C20H23NO6 = 373.4 5mg QQ客服:3257982914
    细圆藤碱 B; Periglaucine B CFN96748 1025023-05-5 C20H23NO6 = 373.40 5mg QQ客服:3257982914
    青藤碱; Sinomenine CFN99508 115-53-7 C19H23NO4 = 329.38 20mg QQ客服:1413575084
    盐酸青藤碱; Sinomenine HCl CFN99561 6080-33-7 C19H23NO4.HCl = 365.85 20mg QQ客服:3257982914
    粉防己G; Fenfangjine G CFN92332 205533-81-9 C22H27NO8 = 433.5 5mg QQ客服:3257982914
    16-氧代原间千金藤碱; 16-Oxoprometaphanine CFN98993 58738-31-1 C20H23NO6 = 373.4 5mg QQ客服:1457312923

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