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  • 远志皂苷元

    Senegenin

    远志皂苷元
    产品编号 CFN99109
    CAS编号 2469-34-3
    分子式 = 分子量 C30H45ClO6 = 537.14
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Polygala tenuifolia Willd.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    远志皂苷元 CFN99109 2469-34-3 10mg QQ客服:1413575084
    远志皂苷元 CFN99109 2469-34-3 20mg QQ客服:1413575084
    远志皂苷元 CFN99109 2469-34-3 50mg QQ客服:1413575084
    远志皂苷元 CFN99109 2469-34-3 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Subang Jaya Medical Centre (Malaysia)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Cornell University (USA)
  • Universidad Veracuzana (Mexico)
  • University of Wuerzburg (Germany)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • MTT Agrifood Research Finland (Finland)
  • University of Indonesia (Indonesia)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Chungnam National University (Korea)
  • Nanjing University of Chinese Medicine (China)
  • University of Bordeaux (France)
  • St. Jude Children Research Hospital (USA)
  • Northeast Normal University Changchun (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Biol Chem.2014, 289(3):1723-31
  • Biomolecules2021, 11(10),1513.
  • Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112
  • Mol Med Rep.2015, 12(5):7789-95
  • Nutraceutical Research . 2021, 19(1),p90-105.
  • Phytomedicine.2017, 24:77-86
  • The Korea Journal of Herbology2019, 34(2):25-32
  • Int J Biol Macromol.2019, 126:653-661
  • Russian J Bioorganic Chemistry 2021, 47:1411-1417.
  • Food Addit Contam Part A.2021, 38(12):1985-1994.
  • Phytother Res.2015, 29(7):1088-96
  • Nutrients2020, 12(3):811.
  • Vietnam J. Chemistry2022, 60(2):211-222
  • Front Pharmacol.2021, 12:652860.
  • Toxicol Rep.2021, 8:1131-1142.
  • Pharmacognosy Magazine2017, 13(52):868-874
  • Medicina (Kaunas).2020, 56(12):685.
  • Nutraceuticals2022, 2(3),150-161
  • Antioxidants (Basel).2020, 9(6):526.
  • Phytother Res.2023, 37(10):4587-4606.
  • J Nat Med.2022, 76(1):59-67.
  • Nutrients.2019, 11(6):E1380
  • Saudi Pharm J2020, 10.1016
  • ...
  • 生物活性
    Description: Senegenin has anti-apoptotic,anti-oxidative,and neuroprotective activities, it might be a potential agent for prevention and treatment of postoperative cognitive dysfunction (POCD) or other neurodegenerative diseases. It also be a potential therapeutic agent against sepsis. Senegenin decreased the levels of TNF-α ,IL-1β, NF-κB.
    Targets: TNF-α | IL Receptor | NF-kB | JNK
    In vitro:
    Zhong Yao Cai. 2013 Sep;36(9):1477-80.
    Neurotrophic effects of senegenin.[Pubmed: 24620696]
    To study the neurotrophic effects of senegenin on the expression of MAP2 mRNA and BDNF mRNA in cultured cerebral cortical neurons.
    METHODS AND RESULTS:
    The newborn rat cerebral cortex neurons were cultured in vitro. LDH assay was used to investigate the effect of senegenin on the neuronal viability and reverse transcription polymerase chain reaction (RT-PCR) was carried out to determine the expression level of MAP2 mRNA and BDNF mRNA. LDH assay showed that senegenin at the concentration of 0. 5 micromol/L,1 micromol/L and 2 micromol/L could obviously enhance the survival of cells and the survival rates were in dose-dependent manner to some extent. Moreover, the low, medium and high concentrations of senegenin significantly increased the expression of MAP2 mRNA and BDNF mRNA.
    CONCLUSIONS:
    The study suggests that suitable dose of senegenin can increase the expression of MAP2 mRNA and BDNF mRNA in cultured cerebral cortical neurons, and its mechanism needs further study.
    In vivo:
    Inflammation. 2016 Apr;39(2):900-6.
    Senegenin Ameliorate Acute Lung Injury Through Reduction of Oxidative Stress and Inhibition of Inflammation in Cecal Ligation and Puncture-Induced Sepsis Rats.[Pubmed: 26945584 ]
    The purpose of this study was to assess the protective effect of senegenin on acute lung injury (ALI) in rats induced by sepsis.
    METHODS AND RESULTS:
    Rat ALI model was reproduced by cecal ligation and puncture (CLP). All rats were randomly divided into five groups: group 1 (control), group 2 (CLP), group 3 (CLP + senegenin 15 mg/kg), group 4 (CLP + senegenin 30 mg/kg), and group 5 (CLP + senegenin 60 mg/kg). CLP + senegenin groups received senegenin by gavage daily for consecutive 5 days, respectively, while the mice in control and CLP groups were given an equivalent volume of saline. We detected the lung wet/dry weight ratios and the histopathology of the lung. The levels of lung tissue myeloperoxidase (MPO), malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH) were determined. Meanwhile, the nuclear factor-kappa B (NF-κB) activation, tumor necrosis factor-alpha (TNF-α), and interleukin-1β (IL-1β) levels were studied. The results demonstrated that senegenin treatment significantly attenuated CLP-induced lung injury, including reduction of lung wet/dry weight ratio, protein leak, infiltration of leukocytes, and MPO activity. In addition, senegenin markedly decreased MDA content and increased SOD activity and GSH level. Serum levels of TNF-α and IL-1β were also decreased by senegenin administration. Furthermore, senegenin administration inhibited the nuclear translocation of NF-κB in the lungs.
    CONCLUSIONS:
    These findings indicate that senegenin exerts protective effects on CLP-induced septic rats. Senegenin may be a potential therapeutic agent against sepsis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8617 mL 9.3086 mL 18.6171 mL 37.2342 mL 46.5428 mL
    5 mM 0.3723 mL 1.8617 mL 3.7234 mL 7.4468 mL 9.3086 mL
    10 mM 0.1862 mL 0.9309 mL 1.8617 mL 3.7234 mL 4.6543 mL
    50 mM 0.0372 mL 0.1862 mL 0.3723 mL 0.7447 mL 0.9309 mL
    100 mM 0.0186 mL 0.0931 mL 0.1862 mL 0.3723 mL 0.4654 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    儿茶酚; Caulophyllogenin CFN91135 52936-64-8 C30H48O5 = 488.7 5mg QQ客服:2056216494
    远志酸; Polygalacic acid CFN99108 22338-71-2 C30H48O6 = 504.71 5mg QQ客服:1413575084
    桔梗皂苷元; Platycodigenin CFN92207 22327-82-8 C30H48O7 = 520.7 10mg QQ客服:1413575084
    美商陆酸; Phytolaccagenic acid CFN91881 54928-05-1 C31H48O6 = 516.71 5mg QQ客服:3257982914
    商陆皂苷元; Phytolaccagenin CFN99844 1802-12-6 C31H48O7 = 532.7 20mg QQ客服:1457312923
    远志酸; Polygalic acid CFN92195 1260-04-4 C29H44O6 = 488.7 20mg QQ客服:1413575084
    苜蓿酸; Medicagenic acid CFN93933 599-07-5 C30H46O6 = 502.68 5mg QQ客服:1457312923
    远志皂苷元; Senegenin CFN99109 2469-34-3 C30H45ClO6 = 537.14 20mg QQ客服:2056216494
    皂皮酸; Quillaic acid CFN96689 631-01-6 C30H46O5 = 486.69 5mg QQ客服:1413575084
    3-beta-O-反式-对-香豆酰马期里酸; 3-beta-O-(trans-p-Coumaroyl)maslinic acid CFN92210 35482-91-8 C39H54O6 = 618.9 5mg QQ客服:2159513211

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