| In vivo: |
| J Ethnopharmacol. 1984 Dec;12(3):271-8. | | Effect of seneciphylline and senecionine on hepatic drug metabolizing enzymes in rats.[Pubmed: 6533413] |
METHODS AND RESULTS:
The effect of oral administration of the pyrrolizidine alkaloids, seneciphylline and senecionine, from Senecio vulgaris (Compositae) on activities of hepatic epoxide hydrase, glutathione-S-transferase, aminopyrine-N-demethylase and arylhydrocarbon hydroxylase (AHH) was investigated in microsomes of young male albino rats. Seneciphylline significantly increased the activities of epoxide hydrase and glutathione-S-transferase but caused reduction of cytochrome P-450 and related monooxygenase activities. Senecionine failed to stimulate epoxide hydrase while it diminished the activities of glutathione-S-transferase, aminopyrine demethylase and AHH.
CONCLUSIONS:
Seneciphylline and senecionine could not produce any prominent in vitro effect on the hepatic drug metabolizing enzymes under study, except slight stimulation of epoxide hydrase activity by both the alkaloids and slight reduction of aminopyrine demethylase activity by senecionine. | | Experientia, 1977, 33(4):498-9. | | Hypertrophy of pulmonary arteries and arterioles with cor pulmonale in rats induced by seneciphylline, a pyrrolizidine alkaloid.[Reference: WebLink] |
METHODS AND RESULTS:
Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, induced, as do also monoclotaline, etc., a marked arterial and arteriolar hypertrophy of the lung of young Wistar rats a month after a single s. c. injection of 50–80 mg/kg. Cor pulmonale with leftward shift of the ventricular septum was also noted. |
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