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  • 亥茅酚苷

    Sec-O-Glucosylhamaudol

    亥茅酚苷
    产品编号 CFN99743
    CAS编号 80681-44-3
    分子式 = 分子量 C21H26O10 = 438.43
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Ledebouriella seseloides.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    亥茅酚苷 CFN99743 80681-44-3 10mg QQ客服:2056216494
    亥茅酚苷 CFN99743 80681-44-3 20mg QQ客服:2056216494
    亥茅酚苷 CFN99743 80681-44-3 50mg QQ客服:2056216494
    亥茅酚苷 CFN99743 80681-44-3 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Shanghai Institute of Biochemistry and Cell Biology (China)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Life Sci.2021, 270:119074.
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • Sci Rep.2018, 8:15059
  • Nutrients.2018, 10(10)
  • Int Immunopharmacol.2022, 106:108603.
  • Food Chem.2021, 377:131976.
  • Nutrients.2022, 14(23):4997.
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  • Eur J Pharmacol.2018, 832:96-103
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  • Mol Med Rep.2015, 12(5):7789-95
  • Molecules.2020, 25(18):4283.
  • Biofactors.2018, 44(2):168-179
  • J Cell Mol Med.2023, 27(10):1423-1435.
  • Foods.2023, 12(12):2412.
  • J. Korean Wood Sci. Technol.2022, 50(5):338-352.
  • Acta horticulturae2017, 1158:257-268
  • Data Science for Genomics2023, 107-128.
  • The Korea Journal of Herbology2016, 29-35
  • J of Food Quality2020, 8851285.
  • BMC Cancer. 2021, 21(1):91.
  • Molecules.2017, 22(2)
  • ...
  • 生物活性
    Description: Sec-O-glucosylhamaudol has anti-inflammatory effect through regulation of p38 Mitogen-Activated Protein Kinase in Lipopolysaccharide-stimulated RAW264.7 cell line. Intrathecal sec-O-glucosylhamaudol has a very strong antinociceptive effect in the formalin test and it seems the effect is related to an opioid receptor.
    Targets: p38MAPK | NF-kB
    In vitro:
    2014 International Symposium and Annual Meeting, 2014.10, 338-338.
    Anti-Inflammatory Effect of Sec-O-glucosylhamaudol from Ledebouriella seseloides through Regulation of p38 Mitogen-Activated Protein Kinase in Lipopolysaccharide-Stimulated RAW264.7 Cell Line[Reference: WebLink]
    Anti-Inflammatory Effect of Sec-O-glucosylhamaudol from Ledebouriella seseloides through Regulation of p38 Mitogen-Activated Protein Kinase in Lipopolysaccharide-Stimulated RAW264.7 Cell Line.
    PLoS One. 2014 Sep 8;9(9):e107279.
    Screening active components from Yu-ping-feng-san for regulating initiative key factors in allergic sensitization.[Pubmed: 25198676]
    Yu-ping-feng-san (YPFS) is a Chinese medical formula that is used clinically for allergic diseases and characterized by reducing allergy relapse. Our previous studies demonstrated that YPFS efficiently inhibited T helper 2 cytokines in allergic inflammation. The underlying mechanisms of action of YPFS and its effective components remain unclear.
    METHODS AND RESULTS:
    In this study, it was shown that YPFS significantly inhibited production of thymic stromal lymphopoietin (TSLP), an epithelial cell-derived initiative factor in allergic inflammation, in vitro and in vivo. A method of human bronchial epithelial cell (16HBE) binding combined with HPLC-MS (named 16HBE-HPLC-MS) was established to explore potential active components of YPFS. The following five components bound to 16HBE cells: calycosin-7-glucoside, ononin, claycosin, Sec-O-Glucosylhamaudol and formononetin. Serum from YPFS-treated mice was analyzed and three major components were detected claycosin, formononetin and cimifugin. Among these, claycosin and formononetin were detected by 16HBE-HPLC-MS and in the serum of YPFS-treated mice. Claycosin and formononetin decreased the level of TSLP markedly at the initial stage of allergic inflammation in vivo. Nuclear factor (NF)-κB, a key transcription factor in TSLP production, was also inhibited by claycosin and formononetin, either in terms of transcriptional activation or its nuclear translocation in vitro. Allergic inflammation was reduced by claycosin and formononetin when they are administered only at the initial stage in a murine model of atopic contact dermatitis.
    CONCLUSIONS:
    Thus, epithelial cell binding combined with HPLC-MS is a valid method for screening active components from complex mixtures of Chinese medicine. It was demonstrated that the compounds screened from YPFS significantly attenuated allergic inflammation probably by reducing TSLP production via regulating NF-κB activation.
    In vivo:
    Korean J Pain. 2017 Apr; 30(2): 98–103.
    Antinociceptive effect of intrathecal sec-O-glucosylhamaudol on the formalin-induced pain in rats.[Pubmed: 28416993]
    The root of Peucedanum japonicum Thunb., a perennial herb found in Japan, the Philippines, China, and Korea, is used as an analgesic. In a previous study, Sec-O-Glucosylhamaudol (SOG) showed an analgesic effect.
    METHODS AND RESULTS:
    This study was performed to examine the antinociceptive effect of intrathecal SOG in the formalin test. Results:Intrathecal SOG showed a significant reduction of the flinching responses at both phases in a dose-dependent manner. Significant effects were showed from the dose of 30 μg and maximum effects were achieved at a dose of 100 μg in both phases. The ED50 value (95% confidence intervals) of intrathecal SOG was 30.3 (25.8–35.5) μg during phase 1, and 48.0 (41.4–55.7) during phase 2. The antinociceptive effects of SOG (100 μg) were significantly reverted at both phases of the formalin test by naloxone.
    CONCLUSIONS:
    Conclusions:These results demonstrate that intrathecal SOG has a very strong antinociceptive effect in the formalin test and it seems the effect is related to an opioid receptor.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2809 mL 11.4043 mL 22.8087 mL 45.6173 mL 57.0216 mL
    5 mM 0.4562 mL 2.2809 mL 4.5617 mL 9.1235 mL 11.4043 mL
    10 mM 0.2281 mL 1.1404 mL 2.2809 mL 4.5617 mL 5.7022 mL
    50 mM 0.0456 mL 0.2281 mL 0.4562 mL 0.9123 mL 1.1404 mL
    100 mM 0.0228 mL 0.114 mL 0.2281 mL 0.4562 mL 0.5702 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    亥茅酚; Hamaudol CFN95115 735-46-6 C15H16O5 = 276.3 10mg QQ客服:3257982914
    3'-O-当归酰基亥茅酚; 3'-O-Angeloylhamaudol CFN91666 84272-84-4 C20H22O6 = 358.39 5mg QQ客服:2159513211
    亥茅酚苷; Sec-O-Glucosylhamaudol CFN99743 80681-44-3 C21H26O10 = 438.43 20mg QQ客服:215959384
    Isoapetalic acid; Isoapetalic acid CFN98450 34366-34-2 C22H28O6 = 388.5 5mg QQ客服:3257982914
    齿阿米素; 甲氧呋豆素; Visnagin CFN97314 82-57-5 C13H10O4 = 230.2 20mg QQ客服:2159513211
    4-羟基-7-(羟基甲基)-5H-呋喃并[3,2-g][1]苯并吡喃-5-酮; Norkhellol CFN98679 4439-68-3 C12H8O5 = 232.2 5mg QQ客服:2159513211
    当归碱; Angelicain CFN98789 49624-66-0 C15H16O6 = 292.3 5mg QQ客服:1457312923
    升麻素; Cimifugin CFN98612 37921-38-3 C16H18O6 = 306.3 20mg QQ客服:1413575084
    prim-O-Glucosylangelicain; prim-O-Glucosylangelicain CFN97422 85889-15-2 C21H26O11 = 454.4 5mg QQ客服:3257982914
    升麻素苷; Prim-O-glucosylcimifugin CFN98104 80681-45-4 C22H28O11 = 468.45 20mg QQ客服:215959384

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