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  • 五味子醇甲

    Schisandrol A

    五味子醇甲
    产品编号 CFN99012
    CAS编号 7432-28-2
    分子式 = 分子量 C24H32O7 = 432.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The fruits of Schisandra chinensis (Turcz.) Baill.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    五味子醇甲 CFN99012 7432-28-2 10mg QQ客服:3257982914
    五味子醇甲 CFN99012 7432-28-2 20mg QQ客服:3257982914
    五味子醇甲 CFN99012 7432-28-2 50mg QQ客服:3257982914
    五味子醇甲 CFN99012 7432-28-2 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad Miguel Hernández (Spain)
  • Northeast Normal University Changchun (China)
  • Mahidol University (Thailand)
  • Technical University of Denmark (Denmark)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Ain Shams University (Egypt)
  • The Ohio State University (USA)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Mahatma Gandhi University (India)
  • Celltrion Chemical Research Institute (Korea)
  • Medical University of South Carolina (USA)
  • Regional Crop Research Institute (Korea)
  • Monash University Sunway Campus (Malaysia)
  • Universitas islam negeri Jakarta (Indonesia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Applied Physics B2021, 127(92).
  • Korean Herb. Med. Inf.2020, 8(2):243-254.
  • Antioxidants (Basel).2022, 11(12):2496.
  • Phytomedicine.2020, 79, 153351
  • Korean J. Food Sci. & Technol.2022, 54(2):241-246
  • Nat Prod Communications2018, 10.1177
  • Agronomy2020, 10(10),1489
  • Yakugaku Zasshi.2018, 138(4):571-579
  • J Cell Physiol.2020, 10.1002
  • Inflammation.2022, 45(6):2529-2543.
  • Int J Mol Sci.2019, 20(23):E6071
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • Mie University2019, 10076.
  • Nutr Cancer.2022, 1-13.
  • Planta Med.2018, 84(15):1101-1109
  • Molecules.2023, 28(8):3414.
  • Exp Biol Med (Maywood).2019, 244(18):1665-1679
  • Sci Rep.2016, 6:25094
  • Antioxidants (Basel).2021, 10(1):112.
  • Phytochem Anal.2013, 24(5):493-503
  • Plants (Basel).2022, 11(21):2947.
  • GENENCELL2023, 25:4356740
  • University of Limpopo2016, 1777
  • ...
  • 生物活性
    Description: Schisandrol A may be a new promising treatment for neurotoxicity, erectile dysfunction and cardiovascular disease.It can inhibit the activities of Pgp,Beta Amyloid,CYP3A4,cGMP,and NOS, the IC(50) value of CYP3A4 is 32.02 microM.
    Targets: ERK | JNK | P450 (e.g. CYP17) | p38MAPK | Caspase
    In vitro:
    Zhong Yao Cai. 2010 Mar;33(3):397-401.
    Protective and therapeutic effects of schisandrol A on Abeta damaged PC12 cells.[Pubmed: 20681306]
    To observe the protective and therapeutic effect of schisandrol A on the Abeta damaged PC12 cells. PC12 cells were damaged by Abeta in vitro.
    METHODS AND RESULTS:
    Morphological changes were observed and the number of cells with neurite was analyzed by phase contrast microscope. The cell viability of PC12 cells was determined by the MTT method. Many dispirited cells with atrophied or fragmented neurites in the Abeta damaged PC12 cells were observed under the microscope. More vital cells with longer neurites were observed in the schisandrol A treated PC12 cells and the number of cells with neurite increased. The difference of cell viability between the two groups was statistical significant.
    CONCLUSIONS:
    Schisandrol A can antagonize the neurotoxicity of Abeta and has protective and therapeutic efficacy on Abeta damaged PC12 cells.
    Breast Cancer . 2018 Mar;25
    Schisandrin A reverses doxorubicin-resistant human breast cancer cell line by the inhibition of P65 and Stat3 phosphorylation[Pubmed: 29181822]
    Background: Multidrug resistance (MDR) in breast cancer therapy occurs frequently. Thus, anti-MDR agents from natural products or synthetic compounds were tested extensively. We have also explored the reverse effect and mechanism of Schisandrin A (Sch A), a natural product, on MCF-7 breast cancer doxorubicin (DOX)-resistant subline MCF-7/DOX. Methods: MTT assay was performed to measure the viability of MCF-7 cells to assess the reverse effect of Sch A. Western blot analysis was used to study the protein levels. Laser scanning confocal microscopy was performed to detect the intercellular DOX and Rhodamine 123 accumulation. The qRT-PCR was used to analysis the target gene expression. Dual-luciferase reporter assay was performed to test the transcriptional activity of P-glycoprotein (P-gp). Results: Sch A, at the concentration of 20 μM, showed selective reverse effect (better than the positive control, verapamil at 5 μM) on MCF-7/DOX cell line but not on BEL-7402/DOX, Hep G2/DOX, and K-562/DOX cells. In addition, Sch A enhanced DOX-induced cleavage of Caspase-9 and PARP levels by increasing intracellular DOX accumulation and inhibiting P-gp function. Furthermore, Sch A selectively suppressed P-gp at gene and protein levels in MCF-7/DOX cells which express high level of MDR1 but not MRP1, MRP3, or BCRP. Besides, Sch A showed inhibitory effect on P-gp transcriptional activity. Sch A significantly reduced p-IκB-α (Ser32) and p-Stat3 (Tyr705) levels which mediate P-gp expression. In addition, Stat3 knockdown enhanced the reverse effect of siP65. The combined effect of siStat3 and siP65 was better than Sch A single treatment in MCF-7/DOX cells. Conclusion: Sch A specifically reverses P-gp-mediated DOX resistance in MCF-7/DOX cells by blocking P-gp, NF-κB, and Stat3 signaling. Inhibition of P65 and Stat3 shows potent anti-MDR effect on MCF-7/DOX cells. Keywords: Doxorubicin; Multidrug resistance; NF-κB; Schisandrin A; Stat3.
    In vivo:
    Cell Mol Biol (Noisy-le-grand). 2016 Mar 31;62(3):115-9.
    Cavernosum smooth muscle relaxation induced by Schisandrol A via the NO-cGMP signaling pathway.[Pubmed: 27064883]
    To evaluate the effect of Schisandrol A on rabbit corpus cavernosum smooth muscle and elucidate the potential mechanism. Penises were obtained from healthy male New Zealand White rabbits (2.5-3.0 kg).
    METHODS AND RESULTS:
    The pre-contracted penis with phenylephrine (Phe, 10 μM) was treated with accumulative concentrations of Schisandrol A (10-7, 10-6, 10-5 and 10-4 M). The change in intracavernosum pressure (ICP) and tension was recorded, cyclic nucleotides in the cavernosum tissue were measured by radioimmunoassay, mRNA level and expression of endothelial nitric oxide synthase (eNOS) and neuronal NOS (nNOS) were measured by real time PCR and western blot respectively. The corpus cavernosum smooth muscle relaxation induced by Schisandrol A was in a dose-dependent manner. Pre-treatment with NOS inhibitor (Nω nitro-L-arginine-methyl ester, L-NAME) or guanylyl cyclase inhibitor (1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one, ODQ) significantly diminished the relaxation. The cyclic guanosine monophosphate (cGMP) level was significantly increased in the cavernosum tissue. Real time PCR and western blot showed the mRNA level and expression of eNOS and nNOS was also upregulated.
    CONCLUSIONS:
    Schisandrol A relaxes the cavernosum smooth muscle by activating NO-cGMP signaling pathway. It may be a new promising treatment for erectile dysfunction and cardiovascular disease.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3121 mL 11.5607 mL 23.1214 mL 46.2428 mL 57.8035 mL
    5 mM 0.4624 mL 2.3121 mL 4.6243 mL 9.2486 mL 11.5607 mL
    10 mM 0.2312 mL 1.1561 mL 2.3121 mL 4.6243 mL 5.7803 mL
    50 mM 0.0462 mL 0.2312 mL 0.4624 mL 0.9249 mL 1.1561 mL
    100 mM 0.0231 mL 0.1156 mL 0.2312 mL 0.4624 mL 0.578 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    R(+)-戈米辛M1; R(+)-Gomisin M1 CFN97309 82467-50-3 C22H26O6 = 386.4 5mg QQ客服:1457312923
    五味子酚; Schisanhenol CFN90364 69363-14-0 C23H30O6 = 402.48 20mg QQ客服:215959384
    戈米辛 K1; Gomisin K1 CFN96724 75629-20-8 C23H30O6 = 402.48 5mg QQ客服:1457312923
    戈米辛M2; Gomisin M2 CFN97306 82425-45-4 C22H26O6 = 386.4 5mg QQ客服:2159513211
    戈米辛 L1; Gomisin L1 CFN96734 82425-43-2 C22H26O6 = 386.44 5mg QQ客服:3257982914
    戈米辛 L2; Gomisin L2 CFN96726 82425-44-3 C22H26O6 = 386.44 5mg QQ客服:1413575084
    异南五味子木脂宁; Isokadsuranin CFN90912 82467-52-5 C23H28O6 = 400.46 5mg QQ客服:2159513211
    五脂酮C; Schisanlignone C CFN92723 144606-83-7 C23H26O7 = 414.5 5mg QQ客服:2159513211
    五味子丙素; Schizandrin C CFN99708 61301-33-5 C22H24O6 = 384.42 20mg QQ客服:2159513211
    五脂酮D; Schisanlignone D CFN92724 144606-84-8 C22H22O7 = 398.4 5mg QQ客服:1457312923

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