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  • 五味子酚

    Schisanhenol

    五味子酚
    产品编号 CFN90364
    CAS编号 69363-14-0
    分子式 = 分子量 C23H30O6 = 402.48
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The fruits of Schisandrachinensis (Turcz.) Baill
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    五味子酚 CFN90364 69363-14-0 10mg QQ客服:215959384
    五味子酚 CFN90364 69363-14-0 20mg QQ客服:215959384
    五味子酚 CFN90364 69363-14-0 50mg QQ客服:215959384
    五味子酚 CFN90364 69363-14-0 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Auckland (New Zealand)
  • Kazusa DNA Research Institute (Japan)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • University of Wollongong (Australia)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • John Innes Centre (United Kingdom)
  • Rio de Janeiro State University (Brazil)
  • Imperial College London (United Kingdom)
  • Tohoku University (Japan)
  • University of Indonesia (Indonesia)
  • MTT Agrifood Research Finland (Finland)
  • Harvard University (USA)
  • Sant Gadge Baba Amravati University (India)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • University of Stuttgart2021, 11682.
  • Enzyme Microb Technol.2022, 153:109941.
  • Evid Based Complement Alternat Med.2021, 2021:5023536.
  • Appl. Sci.2021, 11(1),14.
  • Environ Toxicol.2020, doi: 10.1002
  • Antioxidants (Basel).2022, 11(12):2327.
  • J Pharmaceutical Research Int.2021, 33(41A):275-284.
  • Asian J Beauty Cosmetol2019, 17(3):287-294
  • Front Pharmacol.2022, 13:806869.
  • Viruses2023, 15(6), 1377
  • New Journal of Chemistry2019, 43:12538-12547
  • Int J Mol Sci.2021, 22(19):10405.
  • Microb Biotechnol.2021, 14(5):2009-2024.
  • Exp Mol Med.2020, 52(4):629-642.
  • LWT2021, 138:110397.
  • Metabolites.2020, 10(12):497.
  • Int J Mol Sci.2022, 23(10):5813.
  • Antioxidants (Basel).2021, 10(9):1435.
  • Pharmaceutics.2021, 13(2):187.
  • Preprints2017, 2017120176
  • Sci Rep.2018, 8:9267
  • Molecules.2021, 26(6):1635.
  • J Nat Med.2017, 71(2):380-388
  • ...
  • 生物活性
    Description: Schisanhenol has antioxidative effect on human LDL oxidation, may be through scavenging free radicals; it also has anti-apoptosis effect on BACSs, may be related to its inhibition of ROS generation. Schisanhenol can protect against adriamycin induced heart mitochondrial toxicity.
    Targets: ROS | LDL | ATPase
    In vitro:
    Fitoterapia. 2015 Mar;101:117-24.
    Schisanhenol derivatives and their biological evaluation against tobacco mosaic virus (TMV).[Pubmed: 25598185]
    Schisanhenol (Sol) was isolated from Schisandra rubriflora, and a series of derivatives (1-16, 15a-16a, and 15b-16b) were designed and prepared by chemical modification. The curative and protective effects of these dibenzocyclooctadiene lignan analogues against tobacco mosaic virus (TMV) were evaluated.
    METHODS AND RESULTS:
    Most analogues exhibited stronger protective effects than the positive control ningnanmycin. Dibromoschisanhenol (6) at 0.25mM exhibited the strongest protective activity (83.5±1.8% at 0.25mM), and 14-(3, 5-dibenzyloxy)-benzoyloxyschisanhenol (16) showed a significant curative effect (78.0±3.8% at 0.15mM) that was much stronger than that of the commercial virucide ningnanmycin.
    CONCLUSIONS:
    This study is the first to demonstrate that natural dibenzocyclooctadiene lignans and analogues are active against plant viruses.
    Biomed Environ Sci. 1992 Mar;5(1):57-64.
    Protective effect of schisanhenol against oxygen radical induced mitochondrial toxicity on rat heart and liver.[Pubmed: 1586468]
    Schisanhenol (SAL) had been shown to have potent antioxidant activities. The protective effects of SAL against oxygen radical induced mitochondrial injuries of rat heart and liver were investigated in the present study.
    METHODS AND RESULTS:
    The ferrous-cysteine induced mitochondrial lipid peroxidation was significantly inhibited by SAL, while the loss of ATPase activity induced by the lipid peroxidation was prevented. The rigidification of mitochondrial membrane, as well as swelling, lysis and disintegration of the mitochondria induced by ferrous-cysteine were all significantly inhibited by SAL.
    CONCLUSIONS:
    These results further confirm that SAL possesses antioxidant activity.
    In vivo:
    Sheng Li Ke Xue Jin Zhan. 1998 Jan;29(1):35-8.
    Protective effects of schisanhenol, salvianolic acid A and SY-L on oxidative stress induced injuries of cerebral cells and their mechanisms.[Pubmed: 12501701]
    Oxidative stress may play an important role in neuronal degenerative diseases such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. These disorders make the elderly not being able to live normally and move freely. So it is necessary to find effective antioxidants to prevent or cure the aged persons from diseases related to neuronal degeneration.
    METHODS AND RESULTS:
    Schisanhenol (Sal) and salvianolic acid A (Sal A) are known antioxidants which were isolated from Chinese herbs respectively. SY-L is a totally synthetic new compound.
    CONCLUSIONS:
    The results showed that Sal, Sal A and SY-L significantly protect cerebral cells from the injuries induced by oxidative stress.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4846 mL 12.423 mL 24.846 mL 49.6919 mL 62.1149 mL
    5 mM 0.4969 mL 2.4846 mL 4.9692 mL 9.9384 mL 12.423 mL
    10 mM 0.2485 mL 1.2423 mL 2.4846 mL 4.9692 mL 6.2115 mL
    50 mM 0.0497 mL 0.2485 mL 0.4969 mL 0.9938 mL 1.2423 mL
    100 mM 0.0248 mL 0.1242 mL 0.2485 mL 0.4969 mL 0.6211 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    戈米辛N; Gomisin N CFN90125 69176-52-9 C23H28O6 = 400.46 20mg QQ客服:1413575084
    五味子乙素; Schizandrin B CFN99923 61281-37-6 C23H28O6 = 400.47 20mg QQ客服:2056216494
    戈米辛A; Gomisin A CFN98990 58546-54-6 C23H28O7 = 416.5 20mg QQ客服:2056216494
    R(+)-戈米辛M1; R(+)-Gomisin M1 CFN97309 82467-50-3 C22H26O6 = 386.4 5mg QQ客服:2159513211
    五味子酚; Schisanhenol CFN90364 69363-14-0 C23H30O6 = 402.48 20mg QQ客服:1413575084
    戈米辛 K1; Gomisin K1 CFN96724 75629-20-8 C23H30O6 = 402.48 5mg QQ客服:1413575084
    戈米辛M2; Gomisin M2 CFN97306 82425-45-4 C22H26O6 = 386.4 5mg QQ客服:1413575084
    戈米辛 L1; Gomisin L1 CFN96734 82425-43-2 C22H26O6 = 386.44 5mg QQ客服:215959384
    戈米辛 L2; Gomisin L2 CFN96726 82425-44-3 C22H26O6 = 386.44 5mg QQ客服:2056216494
    异南五味子木脂宁; Isokadsuranin CFN90912 82467-52-5 C23H28O6 = 400.46 5mg QQ客服:3257982914

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