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  • 丹酚酸D

    • 丹酚酸D

    Salvianolic acid D

    丹酚酸D
    		产品编号 CFN90223
    CAS编号 142998-47-8
    分子式 = 分子量 C20H18O10 = 492.44
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The roots of Salvia miltiorrhiza Bge.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    丹酚酸D CFN90223 142998-47-8 1mg QQ客服：1413575084
    丹酚酸D CFN90223 142998-47-8 5mg QQ客服：1413575084
    丹酚酸D CFN90223 142998-47-8 10mg QQ客服：1413575084
    丹酚酸D CFN90223 142998-47-8 20mg QQ客服：1413575084
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
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    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

    PMID: 30417089
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  • Life Sci.2021, 270:119074.
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  • ...
    • 生物活性
    Description: Salvianolic acid and notoginseng triterpenes can promote EA-hy926 and expression of protein, have protective effects on angiogenesis in EA-hy926 cells in vitro.
    In vitro:
    J Pharm Biomed Anal . 2016 Jan 5;117:178-83.
    A Platelet/CMC coupled with offline UPLC-QTOF-MS/MS for screening antiplatelet activity components from aqueous extract of Danshen[Pubmed: 26355772]
    Abstract Platelets play crucial roles in thromboembolic and cardiovascular disease. The main platelets membrane receptors include adenosine diphosphate receptors, thrombin receptors, thromboxane prostanoid receptors and collagen receptors. In this study, a Platelet/CMC coupled with offline UPLC-QTOF-MS/MS system was built to screen antiplatelet activity components from aqueous extract of Danshen, which serve as an agent of antiplatelet aggregation in Traditional Chinese Medicine. Rosmarinic acid, lithospermic acid, salvianolic acid B, two isomers of salvianolic acid B, salvianolic acid C, salvianolic acid D and salvianolic acid H/I were identified as the potential antiplatelet activity components. Moreover, rosmarinic acid, lithospermic acid, salvianolic acid B, salvianolic acid C and danshensu were tested in platelet aggregation in vitro assay. The results suggested their retention time was closely related to the antiplatelet aggregation activities. This study provides a rapid, effective and novel method for screening the potential antiplatelet activity components from Chinese herb medicines. Keywords: Cell membrane chromatography; Danshen; Platelet; UPLC-QTOF-MS/MS.
    In vivo:
    Acta Pharmaceutica Sinica BVolume 5, Issue 3, May 2015, Pages 246–253
    Pharmacokinetic study of salvianolic acid D after oral and intravenous administration in rats[Reference: WebLink]

    METHODS AND RESULTS:
    A sensitive, specific and rapid LC-MS method was developed and validated for the determination of Salvianolic acid D (SalD) in rat plasma. This method used a single quadrupole mass spectrometer with an electrospray ionization (ESI) source. A single ion monitoring scanning (SIM) mode was employed. It showed good linearity over the concentration range from 3.3 to 666.7 ng/mL for the determination of Salvianolic acid D. The R.S.D.% of intra-day and inter-day precision values were no more than 7.69%, and the accuracy was within 91%−104% at all quality control levels.
    CONCLUSIONS:
    This LC-MS method was applied to the pharmacokinetic study of Salvianolic acid D in rats. A two-compartmental model analysis was employed. The bioavailability of Salvianolic acid D was calculated to be 4.159%±0.517%.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0307 mL 10.1535 mL 20.307 mL 40.6141 mL 50.7676 mL
    5 mM 0.4061 mL 2.0307 mL 4.0614 mL 8.1228 mL 10.1535 mL
    10 mM 0.2031 mL 1.0154 mL 2.0307 mL 4.0614 mL 5.0768 mL
    50 mM 0.0406 mL 0.2031 mL 0.4061 mL 0.8123 mL 1.0154 mL
    100 mM 0.0203 mL 0.1015 mL 0.2031 mL 0.4061 mL 0.5077 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    迷迭香酸-4-氧-葡萄糖苷; Rosmarinyl glucoside CFN95297 910028-78-3 C24H26O13 = 522.5 5mg QQ客服：1457312923
    Clinopodic acid E; Clinopodic acid E CFN95595 159736-38-6 C27H22O12 = 538.5 5mg QQ客服：3257982914
    丹酚酸D; Salvianolic acid D CFN90223 142998-47-8 C20H18O10 = 492.44 5mg QQ客服：215959384
    丹酚酸A; Salvianolic acid A CFN99161 96574-01-5 C26H22O10 = 494.45 20mg QQ客服：1413575084
    丹酚酸A甲酯; Methyl salvionolate A CFN92564 1015171-69-3 C27H24O10 = 508.5 5mg QQ客服：1457312923
    异丹酚酸C; Isosalvianolic acid C CFN92565 142115-17-1 C26H20O10 = 492.4 5mg QQ客服：2159513211
    丹酚酸C; Salvianolic acid C CFN98553 115841-09-3 C26H20O10 = 492.44 20mg QQ客服：215959384
    紫草酸; Lithospermic acid CFN98546 28831-65-4 C27H22O12 = 538.46 20mg QQ客服：3257982914
    9-紫草酸甲酯; Monomethyl lithospermate CFN91005 933054-33-2 C28H24O12 = 552.5 10mg QQ客服：2159513211
    丹参酚酸Y; Salvianolic acid Y CFN91004 1638738-76-7 C36H30O16 = 718.6 5mg QQ客服：2159513211

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