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  • 苔黑酚葡萄糖苷

    Sakakin

    苔黑酚葡萄糖苷
    产品编号 CFN98059
    CAS编号 21082-33-7
    分子式 = 分子量 C13H18O7 = 286.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The rhizomes of Curculigo orchioides Gaertn.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    苔黑酚葡萄糖苷 CFN98059 21082-33-7 10mg QQ客服:3257982914
    苔黑酚葡萄糖苷 CFN98059 21082-33-7 20mg QQ客服:3257982914
    苔黑酚葡萄糖苷 CFN98059 21082-33-7 50mg QQ客服:3257982914
    苔黑酚葡萄糖苷 CFN98059 21082-33-7 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Florida A&M University (USA)
  • Regional Crop Research Institute (Korea)
  • Universidad de Antioquia (Colombia)
  • University of Bonn (Germany)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • University of Melbourne (Australia)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Kazusa DNA Research Institute (Japan)
  • Semmelweis Unicersity (Hungary)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Sanford Burnham Medical Research Institute (USA)
  • University of Fribourg (Switzerland)
  • University of Wisconsin-Madison (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytother Res.2019, 33(4):1104-1113
  • J Sep Sci.2018, 41(9):1938-1946
  • J Agric Food Chem.2021, 69(11):3496-3510.
  • Processes2021, 9(5),831.
  • J Med Food.2022, 25(3):272-280.
  • Phytomedicine2022, 104:154337.
  • Environ Toxicol.2020, doi: 10.1002
  • Research on Crops.2017, 18(3):569
  • Eur J Pharmacol.2022, 917:174744.
  • Toxicol Rep.2021, 8:1131-1142.
  • Oncology Letters2018, 4690-4696
  • Journal of Life Science2017, 233-240
  • Industrial Crops and Products2019, 140:111612
  • Korean J. Medicinal Crop Sci.2022, 30(2):124-133
  • CZECH MYCOLOGY2021, 73(1):1-19.
  • Cosmetics2021, 8(3),91.
  • J Nat Prod.2017, 80(4):854-863
  • Mol Microbiol.2019, 112(1):317-332
  • Nutrients.2021, 13(1):254.
  • Institut Pasteur Korea2020, doi: 10.21203.
  • Molecules.2019, 24(11):E2044
  • Int J Mol Sci.2019, 20(16):E4015
  • Med Sci Monit.2019, 25:9499-9508
  • ...
  • 生物活性
    Description: Orcinol glucoside(Sakakin) shows potent antioxidative and anxiolytic activities without sedative effects, it can improve depressive behaviour in chronic unpredictable mild stress (CUMS) rats by downregulating HPA axis hyperactivity and increasing BDNF expression and ERK1/2 phosphorylation in the hippocampus.
    Targets: ERK | BDNF | CORT
    In vitro:
    Chem Pharm Bull (Tokyo). 2005 Aug;53(8):1065-7.
    Antioxidative phenols and phenolic glycosides from Curculigo orchioides.[Pubmed: 16079552]
    A new orcinol glucoside, orcinol-1-O-beta-D-apiofuranosyl-(1-->6)-beta-D-glucopyranoside (3), was isolated from the rhizomes of Curculigo orchioides GAERTN., together with seven known compounds: orcinol glucoside (1), orcinol-1-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranoside (2), curculigoside (Sakakin,4), curculigoside B (5), curculigoside C (6), 2,6-dimethoxyl benzoic acid (7), and syringic acid (8).
    METHODS AND RESULTS:
    The structures of these compounds were elucidated using spectroscopic methods. The antioxidant activities of these isolated compounds were evaluated by colorimetric methods based on their scavenging effects on hydroxyl radicals and superoxide anion radicals, respectively.
    CONCLUSIONS:
    All the compounds showed potent antioxidative activities and the structure-activity relationship is discussed.
    In vivo:
    Eur. Neuropsychopharmacol. ,2014 ,24(1): 172-80.
    Orcinol glucoside produces antidepressant effects by blocking the behavioural and neuronal deficits caused by chronic stress.[Pubmed: 23838013 ]
    This study focused on the antidepressant potential of orcinol glucoside (Sakakin,OG) and its possible mechanisms of action.
    METHODS AND RESULTS:
    We established a depressed rat model using 3 consecutive weeks of chronic unpredictable mild stress (CUMS). The antidepressant-like effect of OG was revealed using the sucrose preference test, the open field test, the forced swimming test (FST), and the tail suspension test (TST). The activity of the hypothalamic-pituitary-adrenal (HPA) axis was evaluated by detecting the serum corticosterone (CORT) concentrations and mRNA expression of corticotrophin-releasing hormone (CRH) in the hypothalamus. The protein expression levels of brain-derived neurotrophic factor (BDNF) and total phosphorylated-ERK1/2 were detected by western blot. The results showed that OG treatment (1.5, 3, or 6mg/kg) alleviated the depression-like behaviour of rats under CUMS, as indicated by the increased sucrose preference and the decreased immobility in both the FST and TST, although the rearing frequency in the open field test increased only in the group that received the lowest dose (1.5mg/kg OG). Rats that received OG treatment exhibited reduced serum CORT levels and CRH mRNA expression in the hypothalamus, suggesting that the hyperactivity of the HPA axis in CUMS rats was reversed by OG treatment. Moreover, OG treatment upregulated the protein levels of BDNF and phosphorylated-ERK1/2 in the hippocampus, even above control levels.
    CONCLUSIONS:
    Our findings suggest that OG improved depressive behaviour in CUMS rats by downregulating HPA axis hyperactivity and increasing BDNF expression and ERK1/2 phosphorylation in the hippocampus.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4928 mL 17.4642 mL 34.9284 mL 69.8568 mL 87.321 mL
    5 mM 0.6986 mL 3.4928 mL 6.9857 mL 13.9714 mL 17.4642 mL
    10 mM 0.3493 mL 1.7464 mL 3.4928 mL 6.9857 mL 8.7321 mL
    50 mM 0.0699 mL 0.3493 mL 0.6986 mL 1.3971 mL 1.7464 mL
    100 mM 0.0349 mL 0.1746 mL 0.3493 mL 0.6986 mL 0.8732 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    藜芦醇; 3,4-Dimethoxybenzyl Alcohol CFN90580 93-03-8 C9H12O3 = 168.19 20mg QQ客服:1413575084
    邻羟基苯乙酮; Ortho-Hydroxyacetophenone CFN93191 118-93-4 C8H8O2 = 136.2 20mg QQ客服:1457312923
    2,4-二羟基苯乙酮; 2,4-Dihydroxyacetophenone CFN97463 89-84-9 C8H8O3 = 152.2 20mg QQ客服:2056216494
    丹皮酚; Paeonol CFN98926 552-41-0 C9H10O3 = 166.2 20mg QQ客服:2159513211
    4-甲氧基水杨酸乙酯; Ethyl 4-methoxysalicylate CFN92590 60770-00-5 C10H12O4 = 196.2 5mg QQ客服:1413575084
    2,5-二羟基苯乙酮; 2,5-Dihydroxyacetophenone CFN93182 490-78-8 C8H8O3 = 152.2 20mg QQ客服:1413575084
    香草乙酮; Acetovanillone CFN90802 498-02-2 C9H10O3 = 166.2 20mg QQ客服:2056216494
    Phloracetophenone 4'-O-glucoside; Phloracetophenone 4'-O-glucoside CFN96153 5027-30-5 C14H18O9 = 330.3 10mg QQ客服:1457312923
    新化合物26; New compound 26 CFN95622 N/A C30H36O16 = 652.6 5mg QQ客服:1413575084
    2',4',6'-三羟基苯乙酮; 2',4',6'-Trihydroxyacetophenone CFN96090 480-66-0 C8H8O4 = 168.2 20mg QQ客服:3257982914

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