柴胡皂苷B2

Saikosaponin B2

	产品编号	CFN99126
	CAS编号	58316-41-9
	分子式 = 分子量	C₄₂H₆₈O₁₃ = 780.98
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The herbs of Bupleurum chinense DC.
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产品名称	产品编号	CAS编号	包装	QQ客服
柴胡皂苷B2	CFN99126	58316-41-9	10mg	QQ客服：1413575084
柴胡皂苷B2	CFN99126	58316-41-9	20mg	QQ客服：1413575084
柴胡皂苷B2	CFN99126	58316-41-9	50mg	QQ客服：1413575084
柴胡皂苷B2	CFN99126	58316-41-9	100mg	QQ客服：1413575084

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Description:

Saikosaponin B2 as an efficient inhibitor of early HCV entry, including neutralization of virus particles, preventing viral attachment, and inhibiting viral entry/fusion. It (5 microM) induces differentiation of B16 melanoma cells, with potentiation of expressions of melanogenesis and tyrosinase.

Targets:

HCV | PKC

In vitro:

J Hepatol. 2015 Mar;62(3):541-8.

Saikosaponin b2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.[Pubmed: 25450204]

A vaccine against hepatitis C virus (HCV) is unavailable and cost-effective antivirals that prevent HCV infection and re-infection, such as in the transplant setting, do not exist. In a search for novel and economical prophylactic agents, we examined the antiviral activity of saikosaponins (SSa, SSb2, SSc, and SSd) from Bupleurum kaoi root (BK) as entry inhibitors against HCV infection.
METHODS AND RESULTS:
Infectious HCV culture systems were used to examine the effect of saikosaponins on the complete virus life cycle (entry, RNA replication/translation, and particle production). Antiviral activity against various HCV genotypes, clinical isolates, and infection of primary human hepatocytes were also evaluated. BK and the saikosaponins potently inhibited HCV infection at non-cytotoxic concentrations. These natural agents targeted early steps of the viral life cycle, while leaving replication/translation, egress, and spread relatively unaffected. In particular, we identified Saikosaponin B2(SSb2) as an efficient inhibitor of early HCV entry, including neutralization of virus particles, preventing viral attachment, and inhibiting viral entry/fusion. Binding analysis, using soluble viral glycoproteins, demonstrated that SSb2 acted on HCV E2. Moreover, SSb2 inhibited infection by several genotypic strains and prevented binding of serum-derived HCV onto hepatoma cells. Finally, treatment with the compound blocked HCV infection of primary human hepatocytes.
CONCLUSIONS:
Due to its potency, SSb2 may be of value for development as an antagonist of HCV entry and could be explored as prophylactic treatment during the course of liver transplantation.

In vivo:

Mol Med Rep . 2019 Aug;20(2):1943-1951.

Antitumor effects of saikosaponin b2 on breast cancer cell proliferation and migration[Pubmed: 31257464]

Abstract Saikosaponin b2 (SSb2) can be extracted from Bupleurum spp. roots (Radix Bupleuri), which belongs to the Umbelliferae family. The current study aimed to explore the effects of SSb2 on proliferation of breast cancer cells and to identify the mechanism by which SSb2 affects breast cancer cell migration. mRNA expression levels of STAT3 and vasodilator‑stimulated phosphoprotein (VASP) were determined and increased expression was observed in 16 breast cancer tissues compared with the paracancerous tissues. MTT, wound healing, colony formation assays and western blot suggested that SSb2 inhibited MCF‑7 proliferation and migration. It was further identified by western blot analysis that SSb2 treatment reduced levels of phosphorylated STAT3, VASP, matrix metallopeptidase (MMP) 2 and MMP9 in MCF‑7 compared with the untreated cells. In addition, it was demonstrated that inhibition of STAT3 phosphorylation decreased VASP expression levels and induction of STAT3 phosphorylation increased VASP levels. Furthermore, it was observed that the treatment of Kunming mice with SSb2 at 30 mg/kg/day for 30 days induced no obvious changes in the liver or kidney tissues, as determined by haematoxylin and eosin staining. In conclusion, these results indicated that SSb2 may be a potential antitumor drug for the treatment of breast cancer, which acts by suppressing proliferation and migration by downregulating the STAT3 signalling pathway and inhibiting the expression of VASP, MMP2 and MMP9 expression.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2804 mL	6.4022 mL	12.8044 mL	25.6089 mL	32.0111 mL
5 mM	0.2561 mL	1.2804 mL	2.5609 mL	5.1218 mL	6.4022 mL
10 mM	0.128 mL	0.6402 mL	1.2804 mL	2.5609 mL	3.2011 mL
50 mM	0.0256 mL	0.128 mL	0.2561 mL	0.5122 mL	0.6402 mL
100 mM	0.0128 mL	0.064 mL	0.128 mL	0.2561 mL	0.3201 mL

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柴胡皂苷B2

Saikosaponin B2

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