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  • Rubrisandrin A

    Rubrisandrin A

    Rubrisandrin A
    产品编号 CFN92278
    CAS编号 919289-30-8
    分子式 = 分子量 C22H28O6 = 388.5
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Lignans
    植物来源 The herbs of Kadsura longipedunculata Finet.et Gagnep
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Rubrisandrin A CFN92278 919289-30-8 1mg QQ客服:1413575084
    Rubrisandrin A CFN92278 919289-30-8 5mg QQ客服:1413575084
    Rubrisandrin A CFN92278 919289-30-8 10mg QQ客服:1413575084
    Rubrisandrin A CFN92278 919289-30-8 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Korea Institute of Oriental Medicine (Korea)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • University of Oslo (Norway)
  • University of Fribourg (Switzerland)
  • CSIRO - Agriculture Flagship (Australia)
  • Amity University (India)
  • Harvard University (USA)
  • University of Toronto (Canada)
  • University of Helsinki (Finland)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Universiti Sains Malaysia (Malaysia)
  • Universidade Católica Portuguesa (Portugal)
  • Chulalongkorn University (Thailand)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Chemistry of plant raw materials2021, 1:pp 139-150
  • Biochem Biophys Res Commun.2017, 494(3-4):587-593
  • Front Aging Neurosci.2018, 10:269
  • Molecules.2017, 22(11)
  • Phytother Res.2019, 33(7):1784-1793
  • J Food Sci Technol.2022, 59(1):212-219.
  • Chem Biol Interact.2016, 258:59-68
  • Chem Biol Interact.2018, 290:44-51
  • J Adv Res.2019, 17:85-94
  • Food Funct.2022, 13(13):6923-6933.
  • Front. Plant Sci.2022, 13:757852.
  • Appl. Sci.2023, 13(17), 9653.
  • Molecules.2018, 23(12):E3103
  • Cell Physiol Biochem.2019, 52(6):1255-1266
  • J Nat Prod.2021, 84(9):2544-2553.
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Evid Based Complement Alternat Med.2020, 2020:8582318.
  • Biomed Pharmacother.2022, 145:112474.
  • BMC Complement Altern Med.2017, 17(1):384
  • Chin. Med.J.Res. Prac.2017, 31(4)
  • J Health Sci Med Res.2023, 31584.
  • J Sep Sci.2018, 41(9):1938-1946
  • Exp Parasitol.2018, 194:67-78
  • ...
  • 生物活性
    Description: Rubrisandrin A is an anti-HIV agent.
    Targets: HIV
    In vitro:
    J Nat Prod. 2006 Dec;69(12):1697-701.
    Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora.[Pubmed: 17190445 ]

    METHODS AND RESULTS:
    Bioactivity-directed fractionation of an ethanolic extract of the fruits of Schisandra rubriflora led to the isolation and identification of dibenzocyclooctadiene lignans including the new lignans Rubrisandrin A (1a + 1b) and B (2) and the known lignans gomisin J (3), (+/-)-gomisin M1 (4), (+)-gomisin M2 (5), schisanhenol (6), deoxyschisandrin, schisantherin B, schisandrin, tigloylgomisin P, gomisin O, angeloylgomisin P, and epigomisin O. Their structure and stereochemistry were determined by spectroscopic methods, including 2D-NMR techniques.
    CONCLUSIONS:
    Compounds 1 and 3-6 were active as anti-HIV agents. (+/-)-Gomisin M1 (4) exhibited the most potent anti-HIV activity, with EC50 and therapeutic index (TI) values of <0.65 microM and >68, respectively.
    Planta Med. 2010 Oct;76(15):1672-7.
    Evaluation of cytotoxic activity of Schisandra chinensis lignans.[Pubmed: 20458670 ]

    METHODS AND RESULTS:
    Using exhaustive chromatographic separation we have isolated (-)-tigloyl-deangeloyl-gomisin F as a novel dibenzocyclooctadiene lignan from schisandra chinensis. With the help of HPLC, we further isolated (+)-schisandrin, (+)-deoxyschisandrin, (+)-γ-schisandrin, (-)-gomisin J, (+)-gomisin A, (-)-gomisin N, (-)-tigloyl-gomisin P, (-)-wuweizisu C, (-)-gomisin D, Rubrisandrin A, (-)-gomisin G, (+)-gomisin K (3) and (-)-schisantherin C. A full NMR description of (-)-schisantherin C was carried out with the aim to confirm previous reports of its structure. Compounds isolated were identified on the basis of UV, IR, (1)H- and (13)C-NMR and MS.
    CONCLUSIONS:
    The cytotoxicity of lignans was tested for the BY-2 cell line alone and as a synergistic effect with the cytotoxic agent camptothecin. Lignans showed various toxicity and synergistic and antagonistic effects on camptothecin-induced cytotoxicity. Cytotoxicity against colon cancer cell line LoVo was also tested.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.574 mL 12.87 mL 25.74 mL 51.4801 mL 64.3501 mL
    5 mM 0.5148 mL 2.574 mL 5.148 mL 10.296 mL 12.87 mL
    10 mM 0.2574 mL 1.287 mL 2.574 mL 5.148 mL 6.435 mL
    50 mM 0.0515 mL 0.2574 mL 0.5148 mL 1.0296 mL 1.287 mL
    100 mM 0.0257 mL 0.1287 mL 0.2574 mL 0.5148 mL 0.6435 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    五味子丙素; Schizandrin C CFN99708 61301-33-5 C22H24O6 = 384.42 20mg QQ客服:215959384
    五脂酮D; Schisanlignone D CFN92724 144606-84-8 C22H22O7 = 398.4 5mg QQ客服:2159513211
    环氧五味子丙素; Schisandrin C epoxide CFN92841 81345-36-0 C22H22O7 = 398.4 5mg QQ客服:2056216494
    Rubrisandrin A; Rubrisandrin A CFN92278 919289-30-8 C22H28O6 = 388.5 5mg QQ客服:2056216494
    五味子甲素; Schizandrin A CFN99922 61281-38-7 C24H32O6 = 416.51 20mg QQ客服:1457312923
    五味子醇甲; Schisandrol A CFN99012 7432-28-2 C24H32O7 = 432.5 20mg QQ客服:2159513211
    五脂酮A; Schisanlignone A CFN92722 135557-67-4 C24H30O7 = 430.5 5mg QQ客服:215959384
    戈米辛N; Gomisin N CFN90125 69176-52-9 C23H28O6 = 400.46 20mg QQ客服:215959384
    五味子乙素; Schizandrin B CFN99923 61281-37-6 C23H28O6 = 400.47 20mg QQ客服:215959384
    戈米辛A; Gomisin A CFN98990 58546-54-6 C23H28O7 = 416.5 20mg QQ客服:3257982914

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