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  • 大黄酸

    Rhein

    大黄酸
    产品编号 CFN99157
    CAS编号 478-43-3
    分子式 = 分子量 C15H8O6 = 284.21
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Anthraquinones
    植物来源 The roots of Rheum palmatum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    大黄酸 CFN99157 478-43-3 10mg QQ客服:215959384
    大黄酸 CFN99157 478-43-3 20mg QQ客服:215959384
    大黄酸 CFN99157 478-43-3 50mg QQ客服:215959384
    大黄酸 CFN99157 478-43-3 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Center for protein Engineering (CIP) (Belgium)
  • Ain Shams University (Egypt)
  • Chang Gung University (Taiwan)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • University of Limpopo (South Africa)
  • University of East Anglia (United Kingdom)
  • China Medical University (Taiwan)
  • University of Parma (Italy)
  • Tokyo Woman's Christian University (Japan)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Northeast Normal University Changchun (China)
  • Technical University of Denmark (Denmark)
  • Chungnam National University (Korea)
  • Aveiro University (Portugal)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Enzyme and Microbial Technology2022, 110002.
  • PLoS One.2021, 16(6):e0248479.
  • Anal Chim Acta.2018, 1039:162-171
  • Analytical Letters 2021, 54(4).
  • Industrial Crops and Products2017, 95:286-295
  • J Med Food.2021, 24(2):151-160.
  • Nutr Res Pract.2020, 14(3):203-217.
  • Applied Biological Chemistry2022, 65(77).
  • J Clin Med.2022, 11(13):3662.
  • Naunyn Schmiedebergs Arch Pharmacol.2021, 394(1):107-115.
  • Evid Based Complement Alternat Med.2020, 2020:2584783.
  • Malaysian Journal of Analytical Sciences2022, 26(2):360-369.
  • Postharvest Biol Tec2019, 149:18-26
  • J Food Biochem.2021, 45(7):e13774.
  • Cancers (Basel).2023, 15(1):293.
  • J Herbmed Pharmacol.2018, 7(4):280-286
  • Int J Med Sci.2020, 17(5):626-631
  • Phytother Res.2015, 29(7):1088-96
  • Front Pharmacol.2021, 12:744624.
  • Int J Cosmet Sci.2019, 41(1):12-20
  • Evid Based Complement Alternat Med.2021, 2021:5023536.
  • Mol Neurobiol.2022, 02873-9.
  • J Med Food.2020, 23(6):633-640.
  • ...
  • 生物活性
    Description: Rhein has many pharmacological effects, including epatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities, it has been proved effective in treatment of experimental diabetic nephropathy , one of the mechanism is the Inhibition of the hexosamine pathway. Rhein has protective effect on liver injury, the mechanisms possibly contribute to its action of antioxidant and anti-inflammatory activity, also associated with its effect of inhibiting TGF-β1 and suppressing the activation of hepatic stellate cells.
    Targets: TNF-α | IL Receptor | MAPK | AP-1 | ROS | Bcl-2/Bax | CDK | TGF-β/Smad | Calcium Channel | NF-kB
    In vitro:
    Phytother Res. 2015 Mar;29(3):407-14.
    Anti-fibrotic and Anti-tumorigenic Effects of Rhein, a Natural Anthraquinone Derivative, in Mammalian Stellate and Carcinoma Cells.[Pubmed: 25510440]
    Anthraquinone compounds have been recognized to possess antiinflammatory, anti-fibrotic and anti-tumour properties and thus applied in human and veterinary therapeutics as active substances of medicinal products. Amongst the anthraquinones isolated from Rheum palmatum, also known as da-huang, rhein was detected as one of the highest metabolite contents in the bloodstream of mammals. The biological activities of rhein therefore deserve detailed investigation.
    METHODS AND RESULTS:
    In this study, we aimed to delineate the mechanism of inhibitory actions of rhein on fibrotic and tumorigenic processes by means of various biochemical assays, such as immunofluorescent staining, real-time polymerase chain reaction (PCR) and western blotting analyses in rat pancreatic stellate cells (LTC-14), human pancreatic ductal adenocarcinoma cells (PANC-1) and human colon carcinoma cells (SW480 and SW620). Our results demonstrated that the application of rhein notably suppressed the mRNA and protein levels of various fibrotic and tumorigenic mediators including alpha-smooth muscle actin, type I collagen, fibronectin, N-cadherin and matrix metalloproteinases in the testing mammalian cells. The mechanism of the suppressive actions of rhein was associated with the modulation of the sonic hedgehog and serine-threonine kinase signalling pathways.
    CONCLUSIONS:
    In conclusion, we suggest that rhein may serve as a therapeutic or an adjuvant agent in anti-fibrotic and anti-tumorigenic approaches.
    Inflammation, 2003, 27(4):233-46.
    Rhein inhibits interleukin-1 beta-induced activation of MEK/ERK pathway and DNA binding of NF-kappa B and AP-1 in chondrocytes cultured in hypoxia: a potential mechanism for its disease-modifying effect in osteoarthritis.[Pubmed: 14527176]

    METHODS AND RESULTS:
    In the present report, we show that bovine articular chondrocytes cultured in low oxygen tension, i.e. in conditions mimicking their hypoxic in vivo environment, respond to IL-1beta (10 ng/mL) by an increased DNA binding activity of NF-kappaB and AP-1 transcription factors. Incubation of the cells with 10(-5) M rhein for 24 h was found to reduce this activity, particularly in the case of AP-1. Mitogen activated kinases (ERK-1 and ERK-2) were activated by exposure of the chondrocytes to 1-h treatment with IL-1beta. This effect was greater in hypoxia (3% O2) than in normoxia (21% O2). Rhein was capable of reducing the IL-1beta-stimulated ERK1/ERK2 pathway whatever the tension of oxygen present in the environment. The level of c-jun protein, an element of AP-1 complex, was increased by exposure of the chondrocytes to IL-1beta after 2, 6, and 24 h. Addition of rhein at 10(-5) M for 24 h did not reduce the c-jun protein amount. The mRNA steady-state levels of collagen type II (COL2A1) and aggrecan core protein were found to be significantly increased by a 24-h treatment with 10(-5) M rhein. This stimulating effect was also observed in the presence of IL-1beta, suggesting that the drug could prevent or reduce the IL-1beta-induced inhibition of extracellular matrix synthesis. IL-1-induced collagenase (MMPI) expression was significantly decreased by rhein in the same conditions. In conclusion, rhein can effectively inhibit the IL-1-activated MAPK pathway and the binding of NF-kappaB and AP-1 transcription factors, two key factors involved in the expression of several proinflammatory genes by chondrocytes. In addition, the drug can reduce the procatabolic effect of the cytokine, by reducing the MMPI synthesis, and enhance the synthesis of matrix components, such as type II collagen and aggrecan.
    CONCLUSIONS:
    These results may explain the antiosteoarthritic properties of rhein and its disease-modifying effects on OA cartilage, in spite of absence of inhibition at prostaglandin level.
    In vivo:
    Acta Pharmacol Sin. 2002 Aug;23(8):739-44.
    Rhein inhibits liver fibrosis induced by carbon tetrachloride in rats.[Pubmed: 12147197]
    To investigate the effect of rhein on liver fibrosis induced by the exposure of carbon tetrachloride (CCl4)/ethanol in rats.
    METHODS AND RESULTS:
    Male Wistar rats were divided into four study groups (n=10 each group): healthy controls, CCl4/ethanol-injured rats left untreated, and CCl4/ethanol-injured rats treated with rhein of low-dose (25 mg/kg) and high-dose (100 mg/kg). Rhein was given once a day since rat received CCl4/ethanol injury. After administration of rhein for 6 weeks rats were killed. The following parameters were determined: the activity of alanine aminotransferase (ALT), hyalauronic acid (HA) and procollagen type III (PC-III) concentrations in serum, liver malondialdehyde (MDA) level, the degree of liver fibrosis, and the expression of alpha-smooth muscle actin (alpha-SMA) and transforming growth factor-beta1 (TGF-beta1) in liver tissue. The treatment of rhein markedly reduced the ALT activity, HA and PC-III concentrations, and liver MDA level in CCl4/ethanol-injured rats (P<0.01). It also improved significantly histological changes of fibrosis and decreased the expression of alpha-SMA and TGF-beta1 in liver of these rats (P<0.05 or P<0.01).
    CONCLUSIONS:
    Rhein has protective effect on liver injury and can inhibit liver fibrosis induced by CCl4/ethanol in rats. The mechanisms possibly contribute to its action of antioxidant and anti-inflammatory activity, also associated with its effect of inhibiting TGF-beta1 and suppressing the activation of hepatic stellate cells.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5185 mL 17.5926 mL 35.1853 mL 70.3705 mL 87.9631 mL
    5 mM 0.7037 mL 3.5185 mL 7.0371 mL 14.0741 mL 17.5926 mL
    10 mM 0.3519 mL 1.7593 mL 3.5185 mL 7.0371 mL 8.7963 mL
    50 mM 0.0704 mL 0.3519 mL 0.7037 mL 1.4074 mL 1.7593 mL
    100 mM 0.0352 mL 0.1759 mL 0.3519 mL 0.7037 mL 0.8796 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    蒽醌-2-羧酸; 2-Anthraquinonecarboxylic acid CFN92537 117-78-2 C15H8O4 = 252.2 20mg QQ客服:2159513211
    大黄酸; Rhein CFN99157 478-43-3 C15H8O6 = 284.21 20mg QQ客服:2056216494
    大黄酸-8-O-β-D-葡萄糖苷; Rhein-8-glucoside CFN93079 34298-86-7 C21H18O11 = 446.36 20mg QQ客服:2159513211
    双醋瑞因; 二乙酰大黄酸; 二乙酰二氢蒽羧酸; Diacerein CFN90145 13739-02-1 C19H12O8 = 368.29 20mg QQ客服:2159513211
    Ophiohayatone C; Ophiohayatone C CFN92701 84-33-3 C15H8O5 = 268.2 5mg QQ客服:2159513211
    1-甲基-2,8-二羟基-3-羧基-9,10-蒽醌; 1-Methyl-2,8-dihydroxy-3-carboxy-9,10-anthraquinone CFN95101 1401414-53-6 C16H10O6 = 298.3 5mg QQ客服:1413575084
    丹宁卡; 3-羟基-1-甲氧基-2-蒽醌甲醛; Damnacanthal CFN98723 477-84-9 C16H10O5 = 282.3 5mg QQ客服:1457312923
    胭脂红酸; Carminic acid CFN94408 1260-17-9 C22H20O13 = 492.39 20mg QQ客服:1413575084
    紫胶色酸E; Laccaic acid E CFN00084 14597-16-1 C24H17NO11 = 495.40 5mg QQ客服:2159513211
    强力霉素; Doxycycline CFN90251 564-25-0 C22H24N2O8 = 444.44 5mg QQ客服:1457312923

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