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  • 利血平

    Reserpine

    利血平
    产品编号 CFN98112
    CAS编号 50-55-5
    分子式 = 分子量 C33H40N2O9 = 608.69
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Alkaloids
    植物来源 The herbs of Rauvolfia vomitoria Afzel.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    利血平 CFN98112 50-55-5 10mg QQ客服:2056216494
    利血平 CFN98112 50-55-5 20mg QQ客服:2056216494
    利血平 CFN98112 50-55-5 50mg QQ客服:2056216494
    利血平 CFN98112 50-55-5 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Semmelweis Unicersity (Hungary)
  • Deutsches Krebsforschungszentrum (Germany)
  • Tokyo Woman's Christian University (Japan)
  • Donald Danforth Plant Science Center (USA)
  • National Chung Hsing University (Taiwan)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Universidad Industrial de Santander (Colombia)
  • Mendel University in Brno (Czech Republic)
  • S.N.D.T. Women's University (India)
  • The University of Newcastle (Australia)
  • Griffith University (Australia)
  • University of Bonn (Germany)
  • FORTH-IMBB (Greece)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Foods.2023, 12(12):2412.
  • Phytochem Anal.2013, 24(5):493-503
  • J Formos Med Assoc.2020, S0929-6646(20)30425-3
  • Cell.2022, 185(23):4298-4316.e21.
  • Trop J Pharm Res.2023, 22(3):283-288.
  • Plant Physiol Biochem.2023, 203:108073.
  • Hum Exp Toxicol.2023, 42:9603271231171642.
  • Heliyon.2022, e12337.
  • Food Chem.2019, 276:768-775
  • Current Enzyme Inhibition2023, 19(1):55-64(10)
  • Biol Pharm Bull.2021, 44(12):1891-1893.
  • Int J Mol Sci.2017, 19(1)
  • J Plant Biotechnol.2023, 50:070-075.
  • Int J Vitam Nutr Res.2022, doi: 10.1024.
  • BMB Rep.2020, 53(4):218-222.
  • Molecules.2019, 24(4):E709
  • Nutr Res Pract.2020, 14(5):478-489.
  • Food Res Int.2019, 123:125-134
  • Pamukkale Medical Journal2022, 15(4):796-803.
  • J Microbiol Biotechnol.2022, 32(2):141-148.
  • Pharmaceutics.2022, 14(12):2765.
  • J Inflamm Res.2022, 15:5347-5359.
  • Bull. Natl. Mus. Nat. Sci.2021, 47(2),109-114.
  • ...
  • 生物活性
    Description: Reserpine is an inhibitor of multidrug efflux pumps, used as an antipsychotic and antihypertensive drug. Reserpine ameliorates Abeta toxicity in the Alzheimer's disease model in Caenorhabditis elegans, it can significantly delay paralysis and increase the longevity in this model.
    Targets: Caspase | SOD | Beta Amyloid | NMDAR
    In vivo:
    Neuromolecular Med. 2014 Jun;16(2):350-9.
    Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice.[Pubmed: 24584520 ]
    Epidemiological studies demonstrate that pain frequently occurs comorbid with depression. Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits analgesic properties and inhibits the expression of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the anterior cingulate cortex of mice. However, the effects of Gent on the reserpine-induced pain/depression dyad and its underlying mechanisms are unclear.
    METHODS AND RESULTS:
    Reserpine administration (1 mg/kg subcutaneous daily for 3 days) caused a significant decrease in the nociceptive threshold as evidenced by the reduced paw withdrawal latency in response to a radiant heat source and mechanical allodynia. Behavioral detection indicated a significant increase in immobility time during a forced swim test, as well as decreased time in the central area and total travel distance in an open field test. Furthermore, reserpinized animals exhibited increased oxidative stress. Systemic Gent administration dose-dependently ameliorated the behavioral deficits associated with reserpine-induced pain/depression dyad. At the same time, the decrease in biogenic amine levels (norepinephrine, dopamine, and serotonin) was integrated with the increase in caspase-3 levels and GluN2B-containing NMDA receptors in the amygdala of the reserpine-injected mice. Gent significantly reversed the changes in the levels of biogenic amines, caspase-3, and GluN2B-containing NMDA receptors in amygdala. However, Gent did not affect the expression of GluN2A-containing NMDA receptors. The inhibitory effects of Gent on oxidative stress were occluded by simultaneous treatment of GluN2B receptors antagonist Ro25-6981.
    CONCLUSIONS:
    Our study provides strong evidence that Gent inhibits reserpine-induced pain/depression dyad by downregulating GluN2B receptors in the amygdala.
    Behav Brain Res. 2013 Sep 15;253:68-77.
    Cognitive, motor and tyrosine hydroxylase temporal impairment in a model of parkinsonism induced by reserpine.[Pubmed: 23831411]
    Studies have suggested that cognitive deficits can precede motor alterations in Parkinson's disease (PD). However, in general, classic animal models are based on severe motor impairment after one single administration of neurotoxins, and thereby do not express the progressive nature of the pathology.
    METHODS AND RESULTS:
    A previous study showed that the repeated administration with a low dose (0.1mg/kg) of the monoamine depleting agent reserpine induces a gradual appearance of motor signs of pharmacological parkinsonism in rats. Here, we showed this repeated treatment with reserpine induced a memory impairment (evaluated by the novel object recognition task) before the gradual appearance of the motor signs. Additionally, these alterations were accompanied by decreased tyrosine hydroxylase (TH) striatal levels and reduced number of TH cells in substantia nigra pars compacta (SNpc). After 30 days without treatment, reserpine-treated animals showed normal levels of striatal TH, partial recovery of TH cells in SNpc, recovery of motor function, but not reversal of the memory impairment. Furthermore, the motor alterations were statistically correlated with decreased TH levels (GD, CA1, PFC and DS) and number of TH cells (SNpc and VTA) in the brain.
    CONCLUSIONS:
    Thus, we extended previous results showing that the gradual appearance of motor impairment induced by repeated treatment with a low dose of reserpine is preceded by short-term memory impairment, as well as accompanied by neurochemical alterations compatible with the pathology of PD.
    Exp Gerontol. 2009 Jun-Jul;44(6-7):462-6.
    Reserpine ameliorates Abeta toxicity in the Alzheimer's disease model in Caenorhabditis elegans.[Pubmed: 19264117 ]

    METHODS AND RESULTS:
    Earlier we have reported that reserpine, an antihypertensive drug, known to downregulate biogenic amines through inhibition of the vesicular monoamine transporter (VMAT), increases longevity of Caenorhabditis elegans with a high quality of life, namely, enhanced and prolonged mobility (Srivastava et al., 2008). As neurodegenerative diseases are of adult onset, we addressed the protective ability of reserpine against neurodegenerative diseases, especially Alzheimer's disease (AD). In the well established AD model in C. elegans, Amyloid beta (Abeta) is expressed in the muscles and Abeta toxicity is manifested as paralysis (Link, 1995).
    CONCLUSIONS:
    In this model, reserpine significantly delayed paralysis and increased the longevity. In addition, reserpine provided thermotolerance, but interestingly the Abeta transcript and expression levels remains grossly unchanged.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6429 mL 8.2144 mL 16.4287 mL 32.8574 mL 41.0718 mL
    5 mM 0.3286 mL 1.6429 mL 3.2857 mL 6.5715 mL 8.2144 mL
    10 mM 0.1643 mL 0.8214 mL 1.6429 mL 3.2857 mL 4.1072 mL
    50 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.6571 mL 0.8214 mL
    100 mM 0.0164 mL 0.0821 mL 0.1643 mL 0.3286 mL 0.4107 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    利血平氮氧化物; Reserpin N-oxide CFN92583 474-48-6 C33H40N2O10 = 624.7 5mg QQ客服:1457312923
    18-β-羟基-3-表-α-育亨宾; 18-Beta-hydroxy-3-epi-alpha-yohimbine CFN92610 81703-06-2 C21H26N2O4 = 370.5 5mg QQ客服:1413575084
    利血平; Reserpine CFN98112 50-55-5 C33H40N2O9 = 608.69 20mg QQ客服:1413575084
    羧酯利血平; Syrosingopine CFN98542 84-36-6 C35H42N2O11 = 666.71 5mg QQ客服:2056216494
    异柯楠碱; Isorauhimbine CFN98762 483-09-0 C21H26N2O3 = 354.5 5mg QQ客服:215959384
    β-育亨宾; beta-Yohimbine CFN98921 549-84-8 C21H26N2O3 = 354.5 5mg QQ客服:2056216494
    α-育亨宾; alpha-Yohimbine CFN99400 131-03-3 C21H26N2O3 = 354.5 5mg QQ客服:2159513211
    盐酸育亨宾; Yohimbine Hydrochloride CFN99511 65-19-0 C21H26N2O3 HCL = 390.91 20mg QQ客服:215959384
    常绿钩吻碱; Sempervirine CFN97173 6882-99-1 C19H16N2 = 272.4 5mg QQ客服:3257982914
    别育享宾; Allo-Yohimbine CFN92577 522-94-1 C21H26N2O3 = 354.5 5mg QQ客服:1413575084

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