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  • 冉乌头碱

    Ranaconitine

    冉乌头碱
    产品编号 CFN93555
    CAS编号 1360-76-5
    分子式 = 分子量 C32H44N2O9 = 600.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Aconitum sinomontanum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    冉乌头碱 CFN93555 1360-76-5 10mg QQ客服:3257982914
    冉乌头碱 CFN93555 1360-76-5 20mg QQ客服:3257982914
    冉乌头碱 CFN93555 1360-76-5 50mg QQ客服:3257982914
    冉乌头碱 CFN93555 1360-76-5 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • LWT - Food Science and Technology2022, 164:113627
  • Molecules.2018, 23(7):E1817
  • Food Sci Biotechnol.2023, 32(7):997-1003.
  • J Nat Prod.2022, 85(5):1351-1362.
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  • Food Chem.2019, 278:683-691
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  • Front Endocrinol (Lausanne).2020, 11:568436.
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  • J Pharmaceutical and Biomedical Analysis2022, 114631.
  • Nutrients.2020, 12(3):595.
  • Phytochem Anal.2023, pca.3305.
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  • J Ethnopharmacol.2020, 260:112988.
  • Antioxidants (Basel).2021, 10(11):1831.
  • Food Chem.2021, 360:130063.
  • J Clin Med.2019, 8(10):E1664
  • Journal of Ginseng Research2022, j.jgr.2022.09.005.
  • Int J Mol Sci.2021, 22(19):10405.
  • The Journal of Phytopharmacology2020, 9(1): 1-4
  • Int J Mol Sci.2018, 19(2)
  • Agriculture.2022, 12(3), 342.
  • ...
  • 生物活性
    Description: Ranaconitine has cardiotoxicity.
    In vitro:
    J Pharm Biomed Anal. 2017 Apr 15;137:84-89.
    Assessment of in vitro cardiotoxicity of extract fractions and diterpene alkaloids from Aconitum leucostomum Worosch: A short communication.[Pubmed: 28104561 ]
    Aconitum leucostomum Worosch is a traditional Chinese medicine (TCM) and has a broad spectrum of health effects, but with a narrow therapeutic window. It is important to identify both the therapeutic ingredients and the toxic components to better utilize this TCM.
    METHODS AND RESULTS:
    The present study investigated the cardiotoxicity of the selected compounds in Aconitum leucostomum Worosch. The effects of extract of A. leucostomum Worosch and the isolated compounds on cardiocardiomyocytes were evaluated in vitro. Five known compounds in this TCM, including three C18-diterpene alkaloids, lappaconitine (2), N-deacetyllappaconitine (3), and ranaconitine (5), and two C19-diterpene alkaloids, delvestidine (1) and anthranoyllycoctonine (4), were isolated from A. leucostomum Worosch. The cardiotoxicity of these components and extract fractions, as measured by lactate dehydrogenase release and apoptosis, was ranked as follows, in descending order: delvestidine>anthranoyllycoctonine>pH 4 fraction>pH 8 fraction>aconitine>N-deacetyllappaconitine>ranaconitine>lappaconitine. The cytotoxicity of these compounds was shown to be dose-dependent, with delvestidine (1) and anthranoyllycoctonine (4) being the two most toxic compounds to cardiomyocytes in our assays.
    CONCLUSIONS:
    These results provide a basis for future rational use of this TCM, reducing side effects while retaining therapeutic effects.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6647 mL 8.3236 mL 16.6472 mL 33.2945 mL 41.6181 mL
    5 mM 0.3329 mL 1.6647 mL 3.3294 mL 6.6589 mL 8.3236 mL
    10 mM 0.1665 mL 0.8324 mL 1.6647 mL 3.3294 mL 4.1618 mL
    50 mM 0.0333 mL 0.1665 mL 0.3329 mL 0.6659 mL 0.8324 mL
    100 mM 0.0166 mL 0.0832 mL 0.1665 mL 0.3329 mL 0.4162 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    乌头原碱; Aconine CFN90248 509-20-6 C25H41NO9 = 499.60 20mg QQ客服:215959384
    德尔塔生; Deltatsine CFN89534 92631-66-8 C25H41NO7 = 467.59 5mg QQ客服:2159513211
    14-去氢布氏翠雀花碱; 14-Dehydrobrowniine CFN89537 4829-56-5 C25H39NO7 = 465.57 5mg QQ客服:215959384
    高乌宁碱; Lappaconine CFN91818 23943-93-3 C23H37NO6 = 423.6 5mg QQ客服:3257982914
    高乌甲素; Lannaconitine CFN90360 32854-75-4 C32H44N2O8 = 584.70 20mg QQ客服:1413575084
    氢溴酸高乌甲素; Lappaconitine Hydrobromide CFN90361 97792-45-5 C32H44N2O8.HBr = 665.61 20mg QQ客服:2056216494
    冉乌头碱; Ranaconitine CFN93555 1360-76-5 C32H44N2O9 = 600.7 20mg QQ客服:215959384
    3-乙酰乌头碱; Acetylaconitine CFN90261 77181-26-1 C36H49NO12 = 687.78 20mg QQ客服:2056216494
    牛七碱; Szechenyine CFN90459 96562-88-8 C36H51NO11 = 673.79 5mg QQ客服:2159513211
    14-苯甲酰基尼奥林; 14-Benzoylneoline CFN96225 99633-05-3 C31H43NO7 = 541.7 5mg QQ客服:2159513211

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