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    冉乌头碱

    Ranaconitine

    冉乌头碱
    产品编号 CFN93555
    CAS编号 1360-76-5
    分子式 = 分子量 C32H44N2O9 = 600.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Aconitum sinomontanum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    冉乌头碱 CFN93555 1360-76-5 10mg QQ客服:1457312923
    冉乌头碱 CFN93555 1360-76-5 20mg QQ客服:1457312923
    冉乌头碱 CFN93555 1360-76-5 50mg QQ客服:1457312923
    冉乌头碱 CFN93555 1360-76-5 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • St. Jude Children Research Hospital (USA)
  • Sri Ramachandra University (India)
  • University of Bonn (Germany)
  • Tokyo Woman's Christian University (Japan)
  • Shanghai Institute of Organic Chemistry (China)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Monash University Sunway Campus (Malaysia)
  • University of Virginia (USA)
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  • Sanford Burnham Prebys Medical Discovery Institute (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Evid Based Complement Alternat Med.2016, 2016:1230294
  • Mol Immunol. 2016, 78:121-132
  • Biochem Pharmacol.2017, 130:10-20
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • Korean J of Food Science&Technology 2017, 49(2):146-150
  • J Nat Med.2018, 72(3):734-744
  • Analytical methods2019, 11(6)
  • J of Essential Oil Research2019, 1677272
  • Molecules.2019, 24(2):E343
  • Molecules.2019, 24(21):E3834
  • Molecules.2019, 24(4):E709
  • J Agric Food Chem.2019, 67(27):7748-7754
  • Process Biochemistry2019, 85:106-115
  • Genes Genomics.2020, 10.1007
  • Front Plant Sci.2020, 10:1705
  • Appl. Sci.2020, 10(23), 8729
  • J Vet Sci.2020, 21(3):e39.
  • Rev. Chim.2020, 71(3),558-564
  • Plants (Basel).2020, 9(11):1422.
  • Natural Product Communications2020, doi: 10.1177.
  • Natural Product Communications2020, doi: 10.1177.
  • Appl. Sci.2021, 11(1),14.
  • J Nat Med.2021, doi: 10.1007.
  • ...
  • 生物活性
    Description: Ranaconitine has cardiotoxicity.
    In vitro:
    J Pharm Biomed Anal. 2017 Apr 15;137:84-89.
    Assessment of in vitro cardiotoxicity of extract fractions and diterpene alkaloids from Aconitum leucostomum Worosch: A short communication.[Pubmed: 28104561 ]
    Aconitum leucostomum Worosch is a traditional Chinese medicine (TCM) and has a broad spectrum of health effects, but with a narrow therapeutic window. It is important to identify both the therapeutic ingredients and the toxic components to better utilize this TCM.
    METHODS AND RESULTS:
    The present study investigated the cardiotoxicity of the selected compounds in Aconitum leucostomum Worosch. The effects of extract of A. leucostomum Worosch and the isolated compounds on cardiocardiomyocytes were evaluated in vitro. Five known compounds in this TCM, including three C18-diterpene alkaloids, lappaconitine (2), N-deacetyllappaconitine (3), and ranaconitine (5), and two C19-diterpene alkaloids, delvestidine (1) and anthranoyllycoctonine (4), were isolated from A. leucostomum Worosch. The cardiotoxicity of these components and extract fractions, as measured by lactate dehydrogenase release and apoptosis, was ranked as follows, in descending order: delvestidine>anthranoyllycoctonine>pH 4 fraction>pH 8 fraction>aconitine>N-deacetyllappaconitine>ranaconitine>lappaconitine. The cytotoxicity of these compounds was shown to be dose-dependent, with delvestidine (1) and anthranoyllycoctonine (4) being the two most toxic compounds to cardiomyocytes in our assays.
    CONCLUSIONS:
    These results provide a basis for future rational use of this TCM, reducing side effects while retaining therapeutic effects.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6647 mL 8.3236 mL 16.6472 mL 33.2945 mL 41.6181 mL
    5 mM 0.3329 mL 1.6647 mL 3.3294 mL 6.6589 mL 8.3236 mL
    10 mM 0.1665 mL 0.8324 mL 1.6647 mL 3.3294 mL 4.1618 mL
    50 mM 0.0333 mL 0.1665 mL 0.3329 mL 0.6659 mL 0.8324 mL
    100 mM 0.0166 mL 0.0832 mL 0.1665 mL 0.3329 mL 0.4162 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    14-去氢布氏翠雀花碱; 14-Dehydrobrowniine CFN89537 4829-56-5 C25H39NO7 = 465.57 5mg QQ客服:2932563308
    高乌甲素; Lannaconitine CFN90360 32854-75-4 C32H44N2O8 = 584.70 20mg QQ客服:1413575084
    氢溴酸高乌甲素; Lappaconitine Hydrobromide CFN90361 97792-45-5 C32H44N2O8.HBr = 665.61 20mg QQ客服:3257982914
    冉乌头碱; Ranaconitine CFN93555 1360-76-5 C32H44N2O9 = 600.7 20mg QQ客服:2056216494
    3-乙酰乌头碱; Acetylaconitine CFN90261 77181-26-1 C36H49NO12 = 687.78 20mg QQ客服:3257982914
    牛七碱; Szechenyine CFN90459 96562-88-8 C36H51NO11 = 673.79 5mg QQ客服:1457312923
    14-苯甲酰基尼奥林; 14-Benzoylneoline CFN96225 99633-05-3 C31H43NO7 = 541.7 5mg QQ客服:1413575084
    苯甲酰乌头原碱; Benzoylaconine CFN98577 466-24-0 C32H45NO10 = 603.7 20mg QQ客服:3257982914
    13-去羟基印乌碱; 13-Dehydroxyindaconintine CFN98583 N/A C34H47NO9 = 613.74 10mg QQ客服:2159513211
    印乌头碱; Indaconitine CFN99501 4491-19-4 C34H47NO10 = 629.82 20mg QQ客服:2932563308

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