| Description: |
Quercetin dihydrate loaded electrospun nanofibrous membrane show antimycotic effect on candida albicans. Clinoptilolite modified with quercetin dihydrate has shown better cytotoxicity compared with clinoptilolite modified with quercetin. The supplementation of quercetin dihydrate and gallate promotes an increase in fecal sterols, which in turn leads to a decreased absorption of dietary cholesterol as well as lower plasma and hepatic cholesterol. |
| Targets: |
HMG-CoA Reductase | SOD | Antifection |
| In vitro: |
| Microporous and Mesoporous Materials, 2012,147( 1): 59-67. | | Modified natural clinoptilolite with quercetin and quercetin dihydrate and the study of their anticancer activity[Reference: WebLink] | Natural zeolite of the clinoptilolite type and their modified forms CTQ and CTQD with low content (0.06% and 1%) of Q and QD have been used for the study of their anticancer activity.
METHODS AND RESULTS:
Carcinoma cell lines Jurkat, CEM, HeLa, MCF7, A549 and MDA were treated with various amounts of natural clinoptilolite and their modified forms CTQ and CTQD. The water content of the channel system influences the cytotoxicity of zeolite. The results of the study of pure CT thermally activated at two different temperatures 110 and 400 °C confirmed the better cytotoxicity of CT activated at 110 °C (CT110) with higher content of water in comparison with CT activated at 400 °C (CT400).
CONCLUSIONS:
Clinoptilolite modified with Quercetin Dihydrate (CTQD) has shown better cytotoxicity compared with clinoptilolite modified with quercetin (CTQ). |
|
| In vivo: |
| Int J Vitam Nutr Res. 2002 May;72(3):161-9. | | Quercetin dihydrate and gallate supplements lower plasma and hepatic lipids and change activities of hepatic antioxidant enzymes in high cholesterol-fed rats.[Pubmed: 12098884 ] | This study was designed to test the lipid-lowering and antioxidant activity of two bioflavonoids, Quercetin Dihydrate and gallate.
METHODS AND RESULTS:
Four groups of rats were given a semisynthetic diet containing 10 g cholesterol/kg for six weeks. The control group received only a high-cholesterol diet, whereas the other three groups received a diet including 1 g lovastatin, 1 g Quercetin Dihydrate, or 1 g gallate/kg. The Quercetin Dihydrate and gallate supplements both significantly lowered the plasma lipid and hepatic cholesterol levels compared to those of the control. The hepatic 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase activity was significantly lowered by the Quercetin Dihydrate when compared to the other groups, while the hepatic acyl CoA: cholesterol acyltransferase (ACAT) activity was only significantly higher in the control group. The overall potential for antioxidant protection was significantly enhanced by the Quercetin Dihydrate and gallate supplements through lowering the plasma and hepatic thiobarbituric acid reactive substances (TBARS) levels and increasing the hepatic superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in high-cholesterol-fed rats.
CONCLUSIONS:
These results suggest that the supplementation of Quercetin Dihydrate and gallate promotes an increase in fecal sterols, which in turn leads to a decreased absorption of dietary cholesterol as well as lower plasma and hepatic cholesterol. |
|
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