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  • 北美芹素

    (+)-Pteryxin

    北美芹素
    产品编号 CFN92559
    CAS编号 13161-75-6
    分子式 = 分子量 C21H22O7 = 386.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The herbs of Peucedanum harry-smithii var. subglabrum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    北美芹素 CFN92559 13161-75-6 10mg QQ客服:1457312923
    北美芹素 CFN92559 13161-75-6 20mg QQ客服:1457312923
    北美芹素 CFN92559 13161-75-6 50mg QQ客服:1457312923
    北美芹素 CFN92559 13161-75-6 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Federal de Santa Catarina (Brazil)
  • Medical University of Gdansk (Poland)
  • Universit?t Basel (Switzerland)
  • Biotech R&D Institute (USA)
  • Agricultural Research Organization (ARO) (Israel)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Stanford University (USA)
  • University of Wollongong (Australia)
  • University of Hull (United Kingdom)
  • Weizmann Institute of Science (Israel)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • University of Cincinnati (USA)
  • Deutsches Krebsforschungszentrum (Germany)
  • University of Helsinki (Finland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Chem Biol Interact.2016, 258:59-68
  • Rev. Chim.2020, 71(3),558-564
  • J Sep Sci.2019, 42(21):3352-3362
  • Phytother Res.2019, 33(5):1490-1500
  • BMC Pharmacol Toxicol.2018, 19(1):5
  • Appl. Sci.2021, 11(1),14.
  • Biochem Biophys Res Commun.2019, 518(4):732-738
  • J Food Sci.2022, 87(11):4905-4916.
  • Antioxidants (Basel).2020, 9(4):284.
  • Journal of Life Science2017, 233-240
  • J Enzyme Inhib Med Chem.2019, 34(1):134-143
  • Int J Mol Sci.2017, 19(1)
  • Front Plant Sci.2018, 9:1424
  • J.of Traditional&Complementary Med.2022, 10.1016:j.jtcme.
  • J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
  • Asian Pac J Cancer Prev. 2020, 21(4):935-941.
  • Functional Ecology2020, doi: 10.1111.
  • Acta Chromatographica2021, 00960.
  • Cell Physiol Biochem.2017, 44(4):1381-1395
  • Int. J. Mol. Sci.2022, 23(8), 4130.
  • Dis Markers.2022, 2022:2380879.
  • Int J Mol Sci.2021, 22(2):770.
  • Applied Biological Chem. 2020, 26(63).
  • ...
  • 生物活性
    Description: (+)-Pteryxin has muscle-relaxant props, it also shows hepatoprotective and nitric oxide prodn. inhibitory activity.
    Targets: NO
    In vitro:
    Food Chem Toxicol . 2017 Nov;109(Pt 2):970-974.
    Pteryxin - A promising butyrylcholinesterase-inhibiting coumarin derivative from Mutellina purpurea[Pubmed: 28286309]
    Abstract Pteryxin is a dihydropyranocoumarin derivative found in Apiaceae family. In this study, pteryxin, which was previously isolated from the fruits of Mutellina purpurea, was investigated for its inhibitory potential against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), which are the key enzymes in the pathology of Alzheimer's disease (AD). The compound was tested in vitro using ELISA microplate reader at 100 μg/ml and found to cause 9.30 ± 1.86% and 91.62 ± 1.53% inhibition against AChE and BChE, respectively. According to our results, pteryxin (IC50 = 12.96 ± 0.70 μg/ml) was found to be a more active inhibitor of BChE than galanthamine (IC50 = 22.16 ± 0.91 μg/ml; 81.93± 2.52% of inhibition at 100 μg/ml). Further study on pteryxin using molecular docking experiments revealed different possible binding modes with both polar and hydrophobic interactions inside the binding pocket of BChE. Top docking solution points out to the formation of two hydrogen bonds with the catalytic residues S198 and H438 of BChE as well as a strong π - π stacking with W231. Therefore, pteryxin as a natural coumarin seems to be a strong BChE inhibitor, which could be considered as a lead compound to develop novel BChE inhibitors for AD treatment. Keywords: Alzheimer's disease; Cholinesterase inhibition; Molecular docking; Pteryxin; Pyranocoumarin.
    Nutrition . 2014 Oct;30(10):1177-84.
    Pteryxin: a coumarin in Peucedanum japonicum Thunb leaves exerts antiobesity activity through modulation of adipogenic gene network[Pubmed: 24993752]
    Abstract Objectives: Partially purified hexane phase (HP) of Peucedanum japonicum Thunb (PJT) was identified as an antiobesity candidate. However, the compound responsible for the antiobesity activity remained unknown. Thus, in this study we isolated the active compound, to determine the mechanisms related to antiobesity activity in vitro. Methods: The HP was fractionated, and the effect on the triacylglycerol (TG) content was evaluated in 3T3-L1 preadipocytes and HepG2 hepatocytes. On the basis of comprehensive spectroscopic analyses, the structure of the active compound was identified as pteryxin, a known compound in PJT. However, to our knowledge, its biological activities against obesity have not been reported previously. The dose-dependent effect on the TG content, and the gene expressions related to adipogenesis, fatty acid catabolism, energy expenditure, lipolysis, and lipogenesis due to pteryxin (10, 15, and 20 μg/mL) were examined in vitro. Results: Pteryxin dose dependently suppressed TG content in both 3T3-L1 adipocytes (by 52.7%, 53.8%, and 57.4%, respectively; P < 0.05) and HepG2 hepatocytes (by 25.2%, 34.1%, and 27.4%, respectively; P < 0.05). Sterol regulatory element-binding protein-1 (SREBP-1c), fatty acid synthase (FASN), and acetyl-coenzyme A carboxylase-1 (ACC1) were down-regulated in pteryxin-treated 3T3-L1 adipocytes (by 18%, 36.1%, and 38.2%, P < 0.05) and HepG2 hepatocytes (by 72.3%, 62.9%, and 38.8%, respectively; P < 0.05). The adipocyte size marker gene, paternally expressed gene1/mesoderm specific transcript (MEST) was down-regulated (by 42.8%; P < 0.05), and hormone-sensitive lipase, a lipid catabolizing gene was up-regulated (by 15.1%; P < 0.05) in pteryxin-treated adipocytes. The uncoupling protein 2 (by 77.5%; P < 0.05) and adiponectin (by 76.3%; P > 0.05) were up-regulated due to pteryxin. Conclusion: Our study demonstrated that pteryxin in PJT plays the key role in regulating the lipid metabolism-related gene network and improving energy production in vitro. Thus, the results suggest pteryxin as a new natural compound to be used as an antiobesity drug in the pharmaceutical industry. Keywords: 3T3-L1 adipocytes; HepG2 hepatocytes; Lipid metabolism; Obesity; Peucedanum japonicum Thunb; Pteryxin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.588 mL 12.94 mL 25.8799 mL 51.7598 mL 64.6998 mL
    5 mM 0.5176 mL 2.588 mL 5.176 mL 10.352 mL 12.94 mL
    10 mM 0.2588 mL 1.294 mL 2.588 mL 5.176 mL 6.47 mL
    50 mM 0.0518 mL 0.2588 mL 0.5176 mL 1.0352 mL 1.294 mL
    100 mM 0.0259 mL 0.1294 mL 0.2588 mL 0.5176 mL 0.647 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    顺式凯尔消旋内酯; cis-Khellactone CFN92799 15645-11-1 C14H14O5 = 262.3 5mg QQ客服:215959384
    d-Laserpitin; d-Laserpitin CFN92710 134002-17-8 C19H20O6 = 344.4 5mg QQ客服:215959384
    (+)-白花前胡甲素; (+)-Praeruptorin A CFN98141 73069-27-9 C22H22O8 = 414.41 5mg QQ客服:1413575084
    白花前胡丁素,(+)-川白芷内酯; Praeruptorin D CFN98142 73069-28-0 C24H26O7 = 426.46 5mg QQ客服:215959384
    白花前胡素E; Praeruptorin E CFN90449 78478-28-1 C24H28O7 = 428.47 5mg QQ客服:1457312923
    北美芹素; (+)-Pteryxin CFN92559 13161-75-6 C21H22O7 = 386.4 20mg QQ客服:3257982914

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