Info: Read More
  • 中药标准品生产商,产品定制服务
  • Science | Nature | Cell | View More

    樱黄素

    Prunetin

    樱黄素
    产品编号 CFN90189
    CAS编号 552-59-0
    分子式 = 分子量 C16H12O5 = 284.26
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Millettia dielsiana
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    樱黄素 CFN90189 552-59-0 10mg QQ客服:2159513211
    樱黄素 CFN90189 552-59-0 20mg QQ客服:2159513211
    樱黄素 CFN90189 552-59-0 50mg QQ客服:2159513211
    樱黄素 CFN90189 552-59-0 100mg QQ客服:2159513211
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Mahatma Gandhi University (India)
  • Tohoku University (Japan)
  • Utrecht University (Netherlands)
  • University of Cincinnati (USA)
  • University of Perugia (Italy)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Universidad Industrial de Santander (Colombia)
  • National Hellenic Research Foundation (Greece)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • University of Beira Interior (Portugal)
  • University of East Anglia (United Kingdom)
  • University of Fribourg (Switzerland)
  • Monash University Sunway Campus (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacogn Mag.2015, 11(43):562-6
  • Arch Pharm Res.2015, 38(6):1080-9
  • J Basic Clin Physiol Pharmacol.2016, 27(1):1-8
  • Chin. Med.J.Res. Prac.2017, 31(4)
  • J Nat Med.2017, 71(4):745-756
  • Plant J.2017, 90(3):535-546
  • BMC Complement Altern Med.2018, 18(1):303
  • Korean J of Medicinal Crop Science2018, 220-226
  • Molecules.2018, 23(7):E1817
  • Asian Journal of Chemistry2018, 30(12):2699-2703
  • Toxins (Basel).2019, 11(10):E575
  • BMC Complement Altern Med.2019, 19(1):339
  • Molecules.2019, 24(24):E4536
  • J Enzyme Inhib Med Chem.2019, 34(1):134-143
  • Chemistry of Natural Compounds2019, 55(1):127-130
  • Int J Food Sci Nutr.2019, 70(7):825-833
  • Cell Metab.2020, S1550-4131(20)30002-4
  • Front Endocrinol (Lausanne).2020, 11:568436.
  • Anesth Pain Med (Seoul).2020, 15(4):478-485.
  • J Vet Sci.2020, 21(3):e39.
  • Molecules.2020, 25(9):2111.
  • J of Applied Biological Chem.2020, 63(2):147-152
  • Natural Product Communications2020, doi: 10.1177.
  • ...
  • 生物活性
    Description: Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesity-related transcription through a feedback mechanism that regulates the expression of adiponectin, adipoR1, adipoR2, and AMPK. Prunetin and biochanin A are potent reducers of NF-κB and ERK activation, zonula occludens 1 tyrosine phosphorylation, and metalloproteinase-mediated shedding activity, which may account for the barrier-improving ability of these isoflavones.
    Targets: NOS | COX | TNF-α | IL Receptor | NF-kB | PGE | IkB | p65 | ERK | PPAR | HMG-CoA Reductase | AMPK | EGFR | IKK
    In vitro:
    Tuberc Respir Dis (Seoul). 2013 Nov;75(5):205-9.
    Effect of Prunetin on TNF-α-Induced MUC5AC Mucin Gene Expression, Production, Degradation of IκB and Translocation of NF-κB p65 in Human Airway Epithelial Cells.[Pubmed: 24348668]
    We investigated whether prunetin significantly affects tumor necrosis factor-α (TNF-α)-induced MUC5AC mucin gene expression, production, inhibitory kappa B (IκB) degradation and nuclear factor kappa B (NF-κB) p65 translocation in human airway epithelial cells.
    METHODS AND RESULTS:
    Confluent NCI-H292 cells were pretreated with prunetin for 30 minutes and then stimulated with TNF-α for 24 hours or the indicated periods. MUC5AC mucin gene expression and mucin protein production were measured by reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. The effect of prunetin on TNF-α-induced degradation of IκB and translocation of NF-κB p65 was investigated by western blot analysis. We found that incubation of NCI-H292 cells with prunetin significantly inhibited mucin production and down-regulated the MUC5AC gene expression induced by TNF-α. Prunetin inhibited TNF-α-induced degradation of IκB and translocation of NF-κB p65.
    CONCLUSIONS:
    This result suggests that prunetin inhibits the NF-κB signaling pathway, which may explain its role in the inhibition of MUC5AC mucin gene expression and production regulated by the NF-κB signaling pathway.
    Free Radic Biol Med. 2014 May;70:255-64.
    Biochanin A and prunetin improve epithelial barrier function in intestinal CaCo-2 cells via downregulation of ERK, NF-κB, and tyrosine phosphorylation.[Pubmed: 24631489]
    The single-layered gut epithelium represents the primary line of defense against environmental stressors; thereby monolayer integrity and tightness are essentially required to maintain gut health and function. To date only a few plant-derived phytochemicals have been described as affecting intestinal barrier function.
    CONCLUSIONS:
    We investigated the impact of 28 secondary plant compounds on the barrier function of intestinal epithelial CaCo-2/TC-7 cells via transepithelial electrical resistance (TEER) measurements. Apart from genistein, the compounds that had the biggest effect in the TEER measurements were biochanin A and prunetin. These isoflavones improved barrier tightness by 36 and 60%, respectively, compared to the untreated control. Furthermore, both isoflavones significantly attenuated TNFα-dependent barrier disruption, thereby maintaining a high barrier resistance comparable to nonstressed cells. In docking analyses exploring the putative interaction with the tyrosine kinase EGFR, these novel modulators of barrier tightness showed very similar values compared to the known tyrosine kinase inhibitor genistein.
    CONCLUSIONS:
    Both biochanin A and prunetin were also identified as potent reducers of NF-κB and ERK activation, zonula occludens 1 tyrosine phosphorylation, and metalloproteinase-mediated shedding activity, which may account for the barrier-improving ability of these isoflavones.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5179 mL 17.5895 mL 35.1791 mL 70.3581 mL 87.9477 mL
    5 mM 0.7036 mL 3.5179 mL 7.0358 mL 14.0716 mL 17.5895 mL
    10 mM 0.3518 mL 1.759 mL 3.5179 mL 7.0358 mL 8.7948 mL
    50 mM 0.0704 mL 0.3518 mL 0.7036 mL 1.4072 mL 1.759 mL
    100 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.7036 mL 0.8795 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6,7,4'-三羟基异黄酮; 6,7,4'-Trihydroxyisoflavone CFN90796 17817-31-1 C15H10O5 = 270.2 10mg QQ客服:1457312923
    黄豆黄素; Glycitein CFN99106 40957-83-3 C16H12O5 = 284.26 20mg QQ客服:3257982914
    Afrormosine; Afrormosine CFN92347 550-79-8 C17H14O5 = 298.3 5mg QQ客服:2932563308
    鸢尾黄素; Tectorigenin CFN99920 548-77-6 C16H12O6 = 300.26 20mg QQ客服:1413575084
    甘草宁N; Gancaonin N CFN95066 129145-52-4 C21H20O6 = 368.4 5mg QQ客服:1413575084
    甘草宁 G; Gancaonin G CFN96524 126716-34-5 C21H20O5 = 352.39 5mg QQ客服:2932563308
    刺桐素 G; Erythrinin G CFN96545 1616592-61-0 C20H18O6 = 354.35 5mg QQ客服:2932563308
    刺桐素 F; Erythrinin F CFN96549 1616592-60-9 C20H18O7 = 370.35 5mg QQ客服:1457312923
    刺桐素 D; Erythrinin D CFN96546 1616592-59-6 C21H18O6 = 366.37 5mg QQ客服:2159513211
    异补骨脂香豆素A; Isoficusin A CFN96554 1914963-20-4 C25H24O5 = 404.47 5mg QQ客服:1457312923

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ1: 2056216494 ; QQ2: 3257982914
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产