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    产品编号 CFN90189
    CAS编号 552-59-0
    分子式 = 分子量 C16H12O5 = 284.26
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Millettia dielsiana
    产品名称 产品编号 CAS编号 包装 QQ客服
    樱黄素 CFN90189 552-59-0 10mg QQ客服:2159513211
    樱黄素 CFN90189 552-59-0 20mg QQ客服:2159513211
    樱黄素 CFN90189 552-59-0 50mg QQ客服:2159513211
    樱黄素 CFN90189 552-59-0 100mg QQ客服:2159513211
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Mahatma Gandhi University (India)
  • Tohoku University (Japan)
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  • University of Cincinnati (USA)
  • University of Perugia (Italy)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Universidad Industrial de Santander (Colombia)
  • National Hellenic Research Foundation (Greece)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • University of Beira Interior (Portugal)
  • University of East Anglia (United Kingdom)
  • University of Fribourg (Switzerland)
  • Monash University Sunway Campus (Malaysia)
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  • ...
  • 生物活性
    Description: Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesity-related transcription through a feedback mechanism that regulates the expression of adiponectin, adipoR1, adipoR2, and AMPK. Prunetin and biochanin A are potent reducers of NF-κB and ERK activation, zonula occludens 1 tyrosine phosphorylation, and metalloproteinase-mediated shedding activity, which may account for the barrier-improving ability of these isoflavones.
    Targets: NOS | COX | TNF-α | IL Receptor | NF-kB | PGE | IkB | p65 | ERK | PPAR | HMG-CoA Reductase | AMPK | EGFR | IKK
    In vitro:
    Tuberc Respir Dis (Seoul). 2013 Nov;75(5):205-9.
    Effect of Prunetin on TNF-α-Induced MUC5AC Mucin Gene Expression, Production, Degradation of IκB and Translocation of NF-κB p65 in Human Airway Epithelial Cells.[Pubmed: 24348668]
    We investigated whether prunetin significantly affects tumor necrosis factor-α (TNF-α)-induced MUC5AC mucin gene expression, production, inhibitory kappa B (IκB) degradation and nuclear factor kappa B (NF-κB) p65 translocation in human airway epithelial cells.
    Confluent NCI-H292 cells were pretreated with prunetin for 30 minutes and then stimulated with TNF-α for 24 hours or the indicated periods. MUC5AC mucin gene expression and mucin protein production were measured by reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. The effect of prunetin on TNF-α-induced degradation of IκB and translocation of NF-κB p65 was investigated by western blot analysis. We found that incubation of NCI-H292 cells with prunetin significantly inhibited mucin production and down-regulated the MUC5AC gene expression induced by TNF-α. Prunetin inhibited TNF-α-induced degradation of IκB and translocation of NF-κB p65.
    This result suggests that prunetin inhibits the NF-κB signaling pathway, which may explain its role in the inhibition of MUC5AC mucin gene expression and production regulated by the NF-κB signaling pathway.
    Free Radic Biol Med. 2014 May;70:255-64.
    Biochanin A and prunetin improve epithelial barrier function in intestinal CaCo-2 cells via downregulation of ERK, NF-κB, and tyrosine phosphorylation.[Pubmed: 24631489]
    The single-layered gut epithelium represents the primary line of defense against environmental stressors; thereby monolayer integrity and tightness are essentially required to maintain gut health and function. To date only a few plant-derived phytochemicals have been described as affecting intestinal barrier function.
    We investigated the impact of 28 secondary plant compounds on the barrier function of intestinal epithelial CaCo-2/TC-7 cells via transepithelial electrical resistance (TEER) measurements. Apart from genistein, the compounds that had the biggest effect in the TEER measurements were biochanin A and prunetin. These isoflavones improved barrier tightness by 36 and 60%, respectively, compared to the untreated control. Furthermore, both isoflavones significantly attenuated TNFα-dependent barrier disruption, thereby maintaining a high barrier resistance comparable to nonstressed cells. In docking analyses exploring the putative interaction with the tyrosine kinase EGFR, these novel modulators of barrier tightness showed very similar values compared to the known tyrosine kinase inhibitor genistein.
    Both biochanin A and prunetin were also identified as potent reducers of NF-κB and ERK activation, zonula occludens 1 tyrosine phosphorylation, and metalloproteinase-mediated shedding activity, which may account for the barrier-improving ability of these isoflavones.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5179 mL 17.5895 mL 35.1791 mL 70.3581 mL 87.9477 mL
    5 mM 0.7036 mL 3.5179 mL 7.0358 mL 14.0716 mL 17.5895 mL
    10 mM 0.3518 mL 1.759 mL 3.5179 mL 7.0358 mL 8.7948 mL
    50 mM 0.0704 mL 0.3518 mL 0.7036 mL 1.4072 mL 1.759 mL
    100 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.7036 mL 0.8795 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6,7,4'-三羟基异黄酮; 6,7,4'-Trihydroxyisoflavone CFN90796 17817-31-1 C15H10O5 = 270.2 10mg QQ客服:1457312923
    黄豆黄素; Glycitein CFN99106 40957-83-3 C16H12O5 = 284.26 20mg QQ客服:3257982914
    Afrormosine; Afrormosine CFN92347 550-79-8 C17H14O5 = 298.3 5mg QQ客服:2932563308
    鸢尾黄素; Tectorigenin CFN99920 548-77-6 C16H12O6 = 300.26 20mg QQ客服:1413575084
    甘草宁N; Gancaonin N CFN95066 129145-52-4 C21H20O6 = 368.4 5mg QQ客服:1413575084
    甘草宁 G; Gancaonin G CFN96524 126716-34-5 C21H20O5 = 352.39 5mg QQ客服:2932563308
    刺桐素 G; Erythrinin G CFN96545 1616592-61-0 C20H18O6 = 354.35 5mg QQ客服:2932563308
    刺桐素 F; Erythrinin F CFN96549 1616592-60-9 C20H18O7 = 370.35 5mg QQ客服:1457312923
    刺桐素 D; Erythrinin D CFN96546 1616592-59-6 C21H18O6 = 366.37 5mg QQ客服:2159513211
    异补骨脂香豆素A; Isoficusin A CFN96554 1914963-20-4 C25H24O5 = 404.47 5mg QQ客服:1457312923





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