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  • 盐酸普罗托平; 盐酸蓝堇碱

    Protopine hydrochloride

    盐酸普罗托平; 盐酸蓝堇碱
    产品编号 CFN98520
    CAS编号 6164-47-2
    分子式 = 分子量 C20H20ClNO5 = 389.83
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Galium aparine L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    盐酸普罗托平; 盐酸蓝堇碱 CFN98520 6164-47-2 10mg QQ客服:2159513211
    盐酸普罗托平; 盐酸蓝堇碱 CFN98520 6164-47-2 20mg QQ客服:2159513211
    盐酸普罗托平; 盐酸蓝堇碱 CFN98520 6164-47-2 50mg QQ客服:2159513211
    盐酸普罗托平; 盐酸蓝堇碱 CFN98520 6164-47-2 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Wageningen University (Netherlands)
  • Shanghai Institute of Organic Chemistry (China)
  • University of Madras (India)
  • University of Hertfordshire (United Kingdom)
  • University of Stirling (United Kingdom)
  • Charles Sturt University (Denmark)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Monash University Malaysia (Malaysia)
  • Agricultural Research Organization (ARO) (Israel)
  • University of Vienna (Austria)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Heidelberg University (Germany)
  • Lodz University of Technology (Poland)
  • Universitas Airlangga (Indonesia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Planta Med.2016, 82(13):1208-16
  • Toxicol Mech Methods.2021, 1-12.
  • Pharmacological Reports2020, 1-9
  • Phytomedicine.2018, 41:62-66
  • J. Food Composition and Analysis2022, 114:104731
  • Front Chem.2022, 10:1048467.
  • Biomol Ther (Seoul).2020, 28(6):542-548.
  • Korean Herb. Med. Inf.2021, 9(2):231-239.
  • Int J Mol Sci.2022, 23(10):5468.
  • Korean J. Food Sci. & Technol.2022, 54(2):241-246
  • ACS Synth Biol.2022, 11(10):3296-3304.
  • Molecules.2019, 24(7):E1290
  • Appl. Sci. 2021, 11(22), 10552
  • Chem Biol Interact.2018, 290:44-51
  • International Food Research Journal2018, 25(6):2560-2571
  • Plants2022, 11(3),294.
  • Appl. Sci. 2021, 11(10),4666.
  • Int J Mol Sci.2021, 22(21):11836.
  • Molecules.2021, 26(12):3652.
  • Applied Biological Chemistry2020, 63:33(2020)
  • Asian Journal of Chemistry2018, 30(12):2699-2703
  • Mol Neurobiol.2021, 58(8):3665-3676.
  • Food Structure2023, 36:100324.
  • ...
  • 生物活性
    Description: Protopine has antiplatelet effects,which is due to inhibition on thromboxane formation and phosphoinositides breakdown and then lead to the decrease of intracellular calcium concentration.Protopine seems to inhibit the heterotypic cell adhesion between MDA-MB-231 cells, and human umbilical vein endothelial cells by changing the expression of adhesive factors.
    Targets: EGFR | cAMP
    In vitro:
    Afr. J.Tradit. Complem., 2014, 11(2):415-24.
    Protopine inhibits heterotypic cell adhesion in MDA-MB-231 cells through down-regulation of multi-adhesive factors.[Pubmed: 25435628 ]
    A Chinese herb Corydalis yanhusuo W.T. Wang that showed anticancer and anti-angiogenesis effects in our previous studies was presented for further studies. In the present study, we studied the anticancer proliferation and adhesion effects of five alkaloids which were isolated from Corydalis yanhusuo.
    METHODS AND RESULTS:
    MTT dose response curves, cell migration assay, cell invasion assay, as well as three types of cell adhesive assay were performed on MDA-MB-231 human breast cancer cells. The mechanism of the compounds on inhibiting heterotypic cell adhesion were further explored by determining the expression of epidermal growth factor receptor (EGFR), Intercellular adhesion molecule 1 (ICAM-1), αv-integrin, β1-integrin and β5-integrin by western blotting assay. In five tested alkaloids, only protopine exhibited anti-adhesive and anti-invasion effects in MDA-MB-231 cells, which contributed to the anti-metastasis effect of Corydalis yanhusuo. The results showed that after treatment with protopine for 90 min, the expression of EGFR, ICAM-1, αv-integrin, β1-integrin and β5-integrin were remarkably reduced.
    CONCLUSIONS:
    The present results suggest that protopine seems to inhibit the heterotypic cell adhesion between MDA-MB-231 cells, and human umbilical vein endothelial cells by changing the expression of adhesive factors.
    Thromb Res. 1989 Oct 15;56(2):289-98.
    Antiplatelet effects of protopine isolated from Corydalis tubers.[Pubmed: 2559491]

    METHODS AND RESULTS:
    Protopine inhibited the aggregation and ATP release of rabbit platelets induced by ADP, arachidonic acid, PAF, collagen and ionophore A23187. Although the platelet aggregation caused by thrombin was not inhibited by protopine (100 micrograms/ml), the release reaction was partially suppressed. In rabbit platelet-rich plasma, protopine also inhibited the platelet aggregation caused by ADP, arachidonic acid, PAF and collagen. The thromboxane B2 formation of washed platelets caused by arachidonic acid, collagen, ionophore A23187 and thrombin was suppressed by protopine. Protopine inhibited the intracellular calcium increase caused by arachidonic acid in quin-2/AM loaded rabbit platelets. In the presence of indomethacin, the intracellular calcium increase caused by collagen and PAF was completely suppressed by protopine, and the intracellular calcium increase caused by thrombin was partially inhibited. The phosphoinositides breakdown caused by collagen and PAF was inhibited by protopine, but that by thrombin was not affected significantly. Protopine did not cause the elevation of cyclic AMP level of platelets.
    CONCLUSIONS:
    It is concluded that the antiplatelet effects of protopine is due to inhibition on thromboxane formation and phosphoinositides breakdown and then lead to the decrease of intracellular calcium concentration.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5652 mL 12.8261 mL 25.6522 mL 51.3044 mL 64.1305 mL
    5 mM 0.513 mL 2.5652 mL 5.1304 mL 10.2609 mL 12.8261 mL
    10 mM 0.2565 mL 1.2826 mL 2.5652 mL 5.1304 mL 6.4131 mL
    50 mM 0.0513 mL 0.2565 mL 0.513 mL 1.0261 mL 1.2826 mL
    100 mM 0.0257 mL 0.1283 mL 0.2565 mL 0.513 mL 0.6413 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
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    3,23-二氧代-9,19-环羊毛甾-24-烯-26-酸 ; 3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid CFN97432 870456-88-5 C30H44O4 = 468.7 5mg QQ客服:1413575084

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