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  • 20(S)-原人参二醇

    (20S)-Protopanaxdiol

    20(S)-原人参二醇
    产品编号 CFN99764
    CAS编号 30636-90-9
    分子式 = 分子量 C30H52O3 = 460.00
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax ginseng C. A. Mey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    20(S)-原人参二醇 CFN99764 30636-90-9 10mg QQ客服:1413575084
    20(S)-原人参二醇 CFN99764 30636-90-9 20mg QQ客服:1413575084
    20(S)-原人参二醇 CFN99764 30636-90-9 50mg QQ客服:1413575084
    20(S)-原人参二醇 CFN99764 30636-90-9 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Dicle (Turkey)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Sri Ramachandra University (India)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • University of Pretoria (South Africa)
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  • Agricultural Research Organization (ARO) (Israel)
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  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean Journal of Pharmacognosy2014, 113-120
  • Nutrients.2019, 11(6):E1380
  • Int J Mol Sci.2022, 23(20):12516.
  • Anal Bioanal Chem.2018, 410(5):1561-1569
  • J Nat Med.2022, 76(1):59-67.
  • Eur J Pharmacol.2021, 899:174010.
  • Molecules.2021, 26(9):2526.
  • Antioxidants.2022, 11(3):592.
  • FASEB J.2022, 36(7):e22387.
  • Life Sci.2018, 209:498-506
  • Front Nutr.2021, 8: 687851.
  • Research Square2023, 2883170.
  • Turk J Med Sci.2023 53: 1312-1320.
  • Agriculture2022, 12(12), 2173.
  • Biol Pharm Bull.2021, 44(12):1891-1893.
  • J Nat Med.2021, doi: 10.1007.
  • Molecules2022, 27(12):3903.
  • Anal Chim Acta.2018, 1039:162-171
  • Nutr Cancer.2023, 75(1):376-387.
  • J Agric Food Chem.2018, 66(1):351-358
  • J Sci Food Agric.2022, 102(4):1628-1639
  • Int J Mol Sci.2020, 21(7):2530.
  • Appl. Sci.2022, 12(4), 2032.
  • ...
  • 生物活性
    Description: 20(S)-Protopanaxdiol may be a potential new P-gp inhibitor for cancer treatment, it may induce the apoptosis via the down-regulation of Bcl-2 protein and the up-regulation of γH2Ax protein expression; it may inhibit the proliferation of Siha cells via the up-regulating the expressions of p53, p21, and autophagy related gene Beclin 1and MAP1-LC3, and down-regulating the expression of cyclin-E.
    Targets: p53 | p21 | Bcl-2/Bax | P-gp | Caspase | γH2Ax
    In vitro:
    Journal of Jilin University, 2013, 39(05):909-12.
    Inhibitory effect of 20(s)-protopanaxdiol on proliferation of Siha cells in vitro and its mechanism.[Reference: WebLink]
    To observe the effect of (20S)-Protopanaxdiol(PPD)on the cell cycle of Siha cells in vitro and to detect the transcription and expressions of p53,p21and cyclin-E,and to clarify the mechanism of its inhibitory effect on proliferation of Siha cells.
    METHODS AND RESULTS:
    The Siha cells cultivated in vitro were treated with alcohol(negative control group)and 20μg·L-1 PPD(PPD group),respectively.The cell cycle was detected by FCM 48h after treatment.The mRNA and protein expressions of p53,p21and cyclin-E in Siha cells were analyzed by Real time PCR and Western blotting. Compared with negative control group,after treated with 20μg·L-1 PPD for 48h,the ratio of Siha cells at G0 /G1 phase was increased(P0.01),the blockage of G1 phase was obviously enhanced;the transcription and protein expressions of p53and p21were up-regulated(P0.01);while the transcription and expression of cyclin-E were significantly decreased(P0.01).
    CONCLUSIONS:
    PPD may inhibit the proliferation of Siha cells,and its mechanism may be related to up-regulating the expressions of p53and p21and down-regulating the expression of cyclin-E.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1739 mL 10.8696 mL 21.7391 mL 43.4783 mL 54.3478 mL
    5 mM 0.4348 mL 2.1739 mL 4.3478 mL 8.6957 mL 10.8696 mL
    10 mM 0.2174 mL 1.087 mL 2.1739 mL 4.3478 mL 5.4348 mL
    50 mM 0.0435 mL 0.2174 mL 0.4348 mL 0.8696 mL 1.087 mL
    100 mM 0.0217 mL 0.1087 mL 0.2174 mL 0.4348 mL 0.5435 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (20R)-原人参二醇; (20R)-Protopanaxdiol CFN99979 7755-01-3 C30H52O3 = 460.74 20mg QQ客服:3257982914
    20(S)-原人参二醇; (20S)-Protopanaxdiol CFN99764 30636-90-9 C30H52O3 = 460.00 20mg QQ客服:1457312923
    20(S)-人参皂苷Rh2; 20(S)-Ginsenoside Rh2 CFN99971 78214-33-2 C36H62O8 = 622.87 20mg QQ客服:3257982914
    20(R)-人参皂苷Rh2; 20(R)-Ginsenoside Rh2 CFN90340 112246-15-8 C36H62O8 = 622.88 20mg QQ客服:1457312923
    人参皂苷Rg3; Ginsenoside Rg3 CFN99969 14197-60-5 C42H72O13 = 785.02 20mg QQ客服:1413575084
    20(R)-人参皂苷Rg3; 20(R)-Ginsenoside Rg3 CFN98170 38243-03-7 C42H72O13 = 785.02 20mg QQ客服:2159513211
    人参皂苷Rs3; Ginsenoside Rs3 CFN92813 194861-70-6 C44H74O14 = 827.1 5mg QQ客服:2056216494
    三七皂苷Ft1; Notoginsenoside Ft1 CFN90859 155683-00-4 C47H80O17 = 917.2 20mg QQ客服:1457312923
    绞股蓝皂苷LI; Gypenoside LI CFN91853 94987-10-7 C42H72O14 = 801.0 5mg QQ客服:1457312923
    绞股蓝皂苷L; Gypenoside L CFN91854 94987-09-4 C42H72O14 = 801.0 5mg QQ客服:2159513211

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