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  • 枸橘苷

    Poncirin

    枸橘苷
    产品编号 CFN90448
    CAS编号 14941-08-3
    分子式 = 分子量 C28H34O14 = 594.56
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The fruits of Poncirus trifoliata (L.) Raf.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    枸橘苷 CFN90448 14941-08-3 10mg QQ客服:215959384
    枸橘苷 CFN90448 14941-08-3 20mg QQ客服:215959384
    枸橘苷 CFN90448 14941-08-3 50mg QQ客服:215959384
    枸橘苷 CFN90448 14941-08-3 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Srinakharinwirot University (Thailand)
  • Subang Jaya Medical Centre (Malaysia)
  • Medical University of Gdansk (Poland)
  • Sant Gadge Baba Amravati University (India)
  • Deutsches Krebsforschungszentrum (Germany)
  • Universite de Lille1 (France)
  • Tokyo Woman's Christian University (Japan)
  • Universidad de La Salle (Mexico)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • University of Helsinki (Finland)
  • Univerzita Karlova v Praze (Czech Republic)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Imperial College London (United Kingdom)
  • University of Pretoria (South Africa)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • Front Pharmacol.2017, 8:205
  • Int Immunopharmacol.2021, 101(Pt A):108181.
  • Life Sci.2018, 209:498-506
  • J Ethnopharmacol.2022, 282:114574.
  • Biomedicines.2021, 9(8):996.
  • Asian Journal of Chemistry2018, 30(12):2699-2703
  • Saf Health Work.2019, 10(2):196-204
  • Elife.2021, 10:e68058.
  • Ecol Evol.2022, 12(11):e9459.
  • Indian J Pharm Sci.2022, 84(4): 874-882.
  • Front Pharmacol.2019, 10:1226
  • J Food Compos Anal2017, 62:197-204
  • J Ethnopharmacol.2019, 236:31-41
  • Food Research International2023, 113792.
  • JMicrobiol Biotech Food Sci2021, e4289.
  • J Food Sci Technol.2022, 59(1):212-219.
  • VNU Journal of Science2023, No. 20.
  • Int J Cosmet Sci.2022, doi:10.1111/ics.12827.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2020, 1149:122123.
  • Integr Med Res.2021, 10(3):100723.
  • Phytochemistry.2021, 181:112539.
  • J Med Food.2020, 23(6):633-640.
  • ...
  • 生物活性
    Description: Poncirin has anticancer, anti-bacterial and anti-inflammatory activities; it prevents adipogenesis, enhances osteoblast differentiation in mesenchymal stem cellsincreased bone mineral density, and improves trabecular microarchitecture likely reflect increases bone formation and decreases bone resorption in GIO mice. Poncirin inhibits iNOS, COX-2, TNF-alpha and IL-6 expression via the down-regulation of NF-kappaB binding activity.
    Targets: PGE | IL Receptor | NOS | COX | TNF-α | NF-kB | p65 | PPAR
    In vitro:
    Int J Mol Sci. 2013 Apr 24;14(5):8684-97.
    Characterization, Purification of Poncirin from Edible Citrus Ougan (Citrus reticulate cv. Suavissima) and Its Growth Inhibitory Effect on Human Gastric Cancer Cells SGC-7901.[Pubmed: 23615464]
    Poncirin is a bitter flavanone glycoside with various biological activities. Poncirin was isolated from four different tissues (flavedo, albedo, segment membrane, and juice sac) of Ougan fruit (Citrus reticulate cv. Suavissima).
    METHODS AND RESULTS:
    The highest content of poncirin was found in the albedo of Ougan fruit (1.37 mg/g DW). High speed counter-current chromatography (HSCCC) combined with D101 resin chromatography was utilized for the separation and purification of poncirin from the albedo of Ougan fruit. After this two-step purification, poncirin purity increased from 0.14% to 96.56%. The chemical structure of the purified poncirin was identified by both HPLC-PDA and LC-MS. Poncirin showed a significant in vitro inhibitory effect on the growth of the human gastric cancer cells, SGC-7901, in a dose-dependent manner.
    CONCLUSIONS:
    Thus, poncirin from Ougan fruit, may be beneficial for gastric cancer prevention. The purification method demonstrated here will be useful for further studies on the pharmacological mechanism of poncirin activity, as well as for guiding the consumption of Ougan fruit.
    J Microbiol Biotechnol. 2015 Jan 28;25(1):18-25.
    Metabolism of rutin and poncirin by human intestinal microbiota and cloning of their metabolizing α-L-rhamnosidase from Bifidobacterium dentium.[Pubmed: 25179902]

    METHODS AND RESULTS:
    To understand the metabolism of flavonoid rhamnoglycosides by human intestinal microbiota, we measured the metabolic activity of rutin and poncirin (distributed in many functional foods and herbal medicine) by 100 human stool specimens. The average α-Lrhamnosidase activities on the p-nitrophenyl-α-L-rhamnopyranoside, rutin, and poncirin subtrates were 0.10 ± 0.07, 0.25 ± 0.08, and 0.15 ± 0.09 pmol/min/mg, respectively. To investigate the enzymatic properties, α-L-rhamnosidase-producing bacteria were isolated from the specimens, and the α-L-rhamnosidase gene was cloned from a selected organism, Bifidobacterium dentium, and expressed in E. coli. The cloned α-L-rhamnosidase gene contained a 2,673 bp sequcence encoding 890 amino acid residues. The cloned gene was expressed using the pET 26b(+) vector in E. coli BL21, and the expressed enzyme was purified using Ni(2+)-NTA and Q-HP column chromatography. The specific activity of the purified α-L-rhamnosidase was 23.3 μmol/min/mg. Of the tested natural product constituents, the cloned α-L-rhamnosidase hydrolyzed rutin most potently, followed by poncirin, naringin, and ginsenoside Re. However, it was unable to hydrolyze quercitrin.
    CONCLUSIONS:
    This is the first report describing the cloning, expression, and characterization of α-L-rhamnosidase, a flavonoid rhamnoglycosidemetabolizing enzyme, from bifidobacteria. Based on these findings, the α-L-rhamnosidase of intestinal bacteria such as B. dentium seem to be more effective in hydrolyzing (1-->6) bonds than (1-->2) bonds of rhamnoglycosides, and may play an important role in the metabolism and pharmacological effect of rhamnoglycosides.
    Biol Pharm Bull. 1999 Apr;22(4):422-4.
    Anti-Helicobacter pylori activity of the metabolites of poncirin from Poncirus trifoliata by human intestinal bacteria.[Pubmed: 10328566]
    Poncirin was isolated from water extract of the fruits of Poncirus trifoliata and metabolized by human intestinal bacteria.
    METHODS AND RESULTS:
    The inhibitory effect of poncirin and its metabolites by these bacteria on the growth of Helicobacter pylori (HP) was investigated. Among them, ponciretin (5,7-dihydroxy-4'-methoxyflavanone), the main metabolite most potently inhibited the growth of HP, with a minimum inhibitory concentration (MIC) of 10-20 microg/ml.
    CONCLUSIONS:
    However, poncirin and its metabolites except ponciretin did not inhibit the growth of HP, nor did they inhibit HP urease.
    In vivo:
    J Bone Miner Metab. 2012 Sep;30(5):509-16.
    Poncirin prevents bone loss in glucocorticoid-induced osteoporosis in vivo and in vitro.[Pubmed: 22407507]
    Poncirin, a flavonoid isolated from the fruit of Poncirus trifoliata, possesses anti-bacterial and anti-inflammatory activities. However, the action of poncirin in bone biology is unclear. In this study, the in vivo and in vitro effects of poncirin in a glucocorticoid-induced osteoporosis (GIO) mouse model were investigated.
    METHODS AND RESULTS:
    Seven-month-old male mice were assigned to the following five groups: (1) sham-implantation (sham), (2) prednisolone 2.1 mg/kg/day (GC), (3) GC treated with 10 mg/kg/day of genistein, (4) GC treated with 3 mg/kg/day of poncirin, (5) and GC treated with 10 mg/kg/day of strontium (GC + SrCl(2)). After 8 weeks, bone loss was measured by microcomputed tomography. Osteocalcin (OC) and C-terminal telopeptides of type I collagen (CTX) were evaluated in sera. Runx2 protein, OC and osteoprotegerin (OPG) mRNA expression, alkaline phosphatase (ALP) activity, and mineral nodule assay were performed in C3H10T1/2 or primary bone marrow stromal cells. Poncirin significantly increased the bone mineral density and improved the microarchitecture. Poncirin increased serum OC, Runx2 protein production, expression of OC and OPG mRNA, ALP activity, and mineral nodule formation; and decreased serum CTX. These effects were more prominent in the poncirin group compared to the other positive control groups (genistein and strontium).
    CONCLUSIONS:
    The poncirin-mediated restoration of biochemical bone markers, increased bone mineral density, and improved trabecular microarchitecture likely reflect increased bone formation and decreased bone resorption in GIO mice.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6819 mL 8.4096 mL 16.8192 mL 33.6383 mL 42.0479 mL
    5 mM 0.3364 mL 1.6819 mL 3.3638 mL 6.7277 mL 8.4096 mL
    10 mM 0.1682 mL 0.841 mL 1.6819 mL 3.3638 mL 4.2048 mL
    50 mM 0.0336 mL 0.1682 mL 0.3364 mL 0.6728 mL 0.841 mL
    100 mM 0.0168 mL 0.0841 mL 0.1682 mL 0.3364 mL 0.4205 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Flavaprin; Flavaprin CFN98900 53846-49-4 C26H30O10 = 502.5 5mg QQ客服:1413575084
    甘草苷; Liquiritin CFN99154 551-15-5 C21H22O9 = 418.39 20mg QQ客服:2056216494
    芹糖甘草苷; Liquiritin apioside CFN90707 74639-14-8 C26H30O13 = 550.5 20mg QQ客服:2159513211
    葡萄糖基甘草苷; Glucoliquiritin CFN95011 93446-18-5 C27H32O14 = 580.5 10mg QQ客服:2159513211
    樱桃甙; 洋李甙; Prunin CFN98878 529-55-5 C21H22O10 = 434.4 20mg QQ客服:2159513211
    柚皮苷; Naringin CFN99555 10236-47-2 C27H32O14 = 580.53 20mg QQ客服:1413575084
    6''-乙酰柚皮苷; Naringin 6''-acetate CFN95418 139934-60-4 C29H34O15 = 622.6 5mg QQ客服:215959384
    Melitidin; Melitidin CFN95419 1162664-58-5 C33H40O18 = 724.7 10mg QQ客服:1457312923
    Theaflavanoside II; Theaflavanoside II CFN95380 943785-09-9 C32H40O18 = 712.6 5mg QQ客服:1413575084
    柚皮苷 4'-葡萄糖苷; Naringin 4'-glucoside CFN95014 17257-21-5 C33H42O19 = 742.7 5mg QQ客服:2056216494

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