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  • 瓜子金皂苷己

    Polygalasaponin F

    瓜子金皂苷己
    产品编号 CFN90171
    CAS编号 882664-74-6
    分子式 = 分子量 C53H86O23 = 1091.3
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Polygala japonica Houtt.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    瓜子金皂苷己 CFN90171 882664-74-6 10mg QQ客服:215959384
    瓜子金皂苷己 CFN90171 882664-74-6 20mg QQ客服:215959384
    瓜子金皂苷己 CFN90171 882664-74-6 50mg QQ客服:215959384
    瓜子金皂苷己 CFN90171 882664-74-6 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Indian Institute of Science (India)
  • University of East Anglia (United Kingdom)
  • University of Indonesia (Indonesia)
  • Technical University of Denmark (Denmark)
  • Kazusa DNA Research Institute (Japan)
  • Cornell University (USA)
  • Medical University of Gdansk (Poland)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • University of the Basque Country (Spain)
  • University of Queensland (Australia)
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  • University of Stirling (United Kingdom)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • National Research Council of Canada (Canada)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Chung Shan Medical University2020, US20200323790A1
  • Nutrients.2022, 14(16):3393.
  • Sci Rep. 2017, 12953(7)
  • Molecules.2023, 28(8):3414.
  • Environ Toxicol.2020, doi: 10.1002
  • Pharmacological Reports2020, 1-9
  • Pharmacogn Mag.2015, 11(43):562-6
  • Antioxidants (Basel).2020, 9(4):284.
  • Nutraceuticals2022, 2(3),150-161
  • Antioxidants (Basel).2021, 10(11): 1802.
  • J Liq Chromatogr R T2018, 41(12):761-769
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • Food Chem.2019, 290:286-294
  • Plant Cell,Tissue & Organ Culture2016, 127(1):115-121
  • Processes2021, 9(1), 153.
  • Front Plant Sci.2022, 13: 905275.
  • Phytomedicine.2019, 58:152893
  • Reprod Sci.2022,10.1007/s43032-022-01117-4.
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • Applied Biological Chemistry2023, 66:85.
  • Plants (Basel).2021, 10(2):278.
  • Molecules.2021, 26(6):1738.
  • Food Bioscience2023, 56:103311.
  • ...
  • 生物活性
    Description: Polygalasaponin F possesses anxiolytic and sedative-hypnotic activities, and has cognition improving and cerebral protective effects. Polygalasaponin F can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Polygalasaponin F can induce long-term potentiation in hippocampal dentate gyrus in anesthetized rats via NMDAR activation mediated by Ca(2+)/calmodulin-dependent kinase II, extracellular signal-regulated kinase and cAMP response element-binding protein signaling pathway.
    Targets: NF-kB | TNF-α | NO | NOS | NMDAR | ERK | cAMP | Calcium Channel | p38MAPK | JNK | p65 | p53 | Bcl-2/Bax | Caspase
    In vitro:
    J Asian Nat Prod Res. 2014;16(8):865-75.
    Polygalasaponin F inhibits secretion of inflammatory cytokines via NF-κB pathway regulation.[Pubmed: 25082394]
    To study the anti-neuroinflammatory mechanisms of polygalasaponin F (PS-F), ELISA method was used to detect the secretion of inflammatory cytokines.
    METHODS AND RESULTS:
    Western blot was used to detect the protein expression and phosphorylation levels. Immunofluorescence assay was used to observe the NF-κB nuclear translocation. PS-F could inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases (iNOS). As for MAPK-signaling pathway, PS-F could only inhibit the phosphorylation levels of p38 MAPK, but did not significantly affect the phosphorylation levels of JNK and ERK1/2 protein kinases. PS-F could inhibit NF-κB nuclear translocation in a dose-dependent manner. The results of Western blot assay were consistent with immunofluorescence assays. Meanwhile, p38-specific inhibitor SB203580 (20 μM) and p65-specific inhibitor PDTC (100 μM) were, respectively, administered as a positive control. In addition, PS-F could significantly inhibit the cytotoxicity of conditioned medium prepared by LPS-stimulated BV-2 microglia (LPS conditioned media) to neuronal PC12 cells and improve cell viability.
    CONCLUSIONS:
    PS-F inhibits the secretions of neuroinflammatory cytokines by the regulation of NF-κB-signaling pathway.
    J Asian Nat Prod Res. 2014 Jan;16(1):59-69.
    Polygalasaponin F against rotenone-induced apoptosis in PC12 cells via mitochondria protection pathway.Polygalasaponin F against rotenone-induced apoptosis in PC12 cells via mitochondria protection pathway.[Pubmed: 24382325]
    To investigate the protective effect and the underlying mechanism of Polygalasaponin F (PS-F) against rotenone-induced PC12 cells, the cell viability was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay.
    METHODS AND RESULTS:
    The cell apoptosis rate was analyzed using flow cytometry. The reactive oxygen species was examined using 2',7'-dichlorofluorescin diacetate, and the adenosine triphosphate depletion was examined using a luciferase-coupled quantification assay. JC-1 staining was used to detect the mitochondrial membrane potential. Western blotting analysis was used to determine cytochrome c, p53, Bax, Bcl-2, and caspase-3. Treatment of PC12 cells with rotenone (1-10 μmol/l) significantly reduced the cell viability in a concentration-dependent manner. Treatment with Polygalasaponin F (0.1, 1, and 10 μmol/l) increased the viability of rotenone-induced PC12 cells, decreased rotenone-induced apoptosis, restored rotenone-induced mitochondrial dysfunction, and suppressed rotenone-induced protein expression. Polygalasaponin F showed a dose-dependent manner in all the treatments. Polygalasaponin F protects PC12 cells against rotenone-induced apoptosis via ameliorating the mitochondrial dysfunction.
    CONCLUSIONS:
    Thus, Polygalasaponin F may be a potential bioactive compound for the treatment of Parkinson's disease.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9163 mL 4.5817 mL 9.1634 mL 18.3268 mL 22.9085 mL
    5 mM 0.1833 mL 0.9163 mL 1.8327 mL 3.6654 mL 4.5817 mL
    10 mM 0.0916 mL 0.4582 mL 0.9163 mL 1.8327 mL 2.2908 mL
    50 mM 0.0183 mL 0.0916 mL 0.1833 mL 0.3665 mL 0.4582 mL
    100 mM 0.0092 mL 0.0458 mL 0.0916 mL 0.1833 mL 0.2291 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    川续断皂苷X; Dipsacus saponin X CFN95359 146100-01-8 C76H124O40 = 1677.8 20mg QQ客服:2056216494
    虎掌草皂苷B; Huzhangoside B CFN91053 94795-70-7 C64H104O29 = 1337.51 5mg QQ客服:3257982914
    虎掌草皂苷C; Huzhangoside C CFN95711 96315-52-5 C64H104O29 = 1337.5 20mg QQ客服:215959384
    虎掌草皂甙D; Huzhangoside D CFN90384 96315-53-6 C64H104O30 = 1353.51 5mg QQ客服:2159513211
    灰毡毛忍冬皂苷B; 灰毡毛忍冬皂苷乙; Macranthoidin B CFN99148 136849-88-2 C65H106O32 = 1399.52 20mg QQ客服:215959384
    桔梗皂苷D2; Platycodin D2 CFN93260 66663-90-9 C63H102O33 = 1387.5 5mg QQ客服:3257982914
    Platycoside E; Platycoside E CFN90786 237068-41-6 C69H112O38 = 1549.6 5mg QQ客服:1413575084
    青葙苷H; Celosin H CFN91669 1623405-28-6 C47H72O20 = 957.06 10mg QQ客服:1457312923
    青葙苷I; Celosin I CFN91061 1807732-38-2 C53H82O24 = 1103.2 10mg QQ客服:3257982914
    青葙苷J; Celosin J CFN91152 1623405-29-7 C58H90O28 = 1235.3 5mg QQ客服:1413575084

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