Info: Read More
  • 中药标准品生产商,产品定制服务
  • 罗汉松黄酮A

    Podocarpusflavone A

    罗汉松黄酮A
    产品编号 CFN98202
    CAS编号 22136-74-9
    分子式 = 分子量 C31H20O10 = 552.5
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The barks of Podocarpus macrophyllus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    罗汉松黄酮A CFN98202 22136-74-9 1mg QQ客服:1413575084
    罗汉松黄酮A CFN98202 22136-74-9 5mg QQ客服:1413575084
    罗汉松黄酮A CFN98202 22136-74-9 10mg QQ客服:1413575084
    罗汉松黄酮A CFN98202 22136-74-9 20mg QQ客服:1413575084
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Chinese University of Hong Kong (China)
  • Gyeongsang National University (Korea)
  • Northeast Normal University Changchun (China)
  • Weizmann Institute of Science (Israel)
  • National Chung Hsing University (Taiwan)
  • Universidade de Franca (Brazil)
  • University of South Australia (Australia)
  • Universidade Católica Portuguesa (Portugal)
  • Lund University (Sweden)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Chungnam National University (Korea)
  • University of Liège (Belgium)
  • Shanghai University of TCM (China)
  • Universidad Miguel Hernández (Spain)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Med Food.2022, 25(3):272-280.
  • Nutr Res Pract.2020, 14(5):478-489.
  • Molecules.2020, 25(20):4851.
  • Pharmacol Rep.2022, 74(1):175-188.
  • Tissue Cell.2022, 75:101728.
  • Int J Mol Sci.2020, 21(6):2190.
  • Postharvest Biol Tec2019, 149:18-26
  • Neurochem Int.2020, 133:104629
  • Plant Biotechnology Reports 2021, 15:117-124.
  • Evid Based Complement Alternat Med.2021, 8707280.
  • Chin J Appl. Physiol.2019, 35(3):283-288
  • Drug Chem Toxicol.2020, 1-12.
  • Nutrients.2021, 13(1):254.
  • Appl. Sci. 2021, 11(17),7829
  • Front Pharmacol.2019, 10:1025
  • Inflammation.2022, 45(6):2529-2543.
  • Plant Cell,Tissue & Organ Culture2016, 127(1):115-121
  • J Bone Miner Res.2017, 32(12):2415-2430
  • Biomed Pharmacother.2020, 128:110318.
  • Am J Chin Med.2023, 51(4):1019-1039.
  • Exp Mol Med.2020, 52(4):629-642.
  • Tropical Journal of Pharmaceutical Research 2021, 20(6):1165-1170.
  • J Agric Food Chem.2021, 69(46):14037-14047.
  • ...
  • 生物活性
    Description: Podocarpusflavone A is the strongest noncytotoxic non-nucleotide molecule exhibiting a specific inhibitory activity against the RNA polymerase domain of DV-NS5 and thus is promising for chemotherapy development against dengue fever. Podocarpusflavone A also shows antimalarial activity in vitro against the chloroquine-sensitive F32 and chloroquine-resistant FcM29 strains of Plasmodium falciparum.
    Targets: DNA/RNA Synthesis | Antifection
    In vitro:
    Planta Med. 2012 May;78(7):672-7.
    Biflavonoids of Dacrydium balansae with potent inhibitory activity on dengue 2 NS5 polymerase.[Pubmed: 22411725]
    In order to find new molecules for antiviral drug design, we screened 102 ethyl acetate extracts from New-Caledonian flora for antiviral activity against the dengue 2 virus RNA-dependant RNA polymerase (DV-NS5 RdRp).
    METHODS AND RESULTS:
    The leaf extract of Dacrydium balansae, which strongly inhibited the DV-NS5, was submitted to bioguided fractionation. Four biflavonoids ( 1- 4), three sterols ( 5- 7), and two stilbene derivatives ( 8- 9) were identified and evaluated for their antiviral potential on the DV-NS5 RdRp. Biflavonoids appeared to be potent inhibitors of DV-NS5 RdRp with IC (50)s between 0.26 and 3.12 µM. Inhibitory activity evaluations against the RNA polymerase from other Flaviviridae viruses allowed us to conclude that these compounds are specific inhibitors of the DV RNA polymerase. The strongest inhibitions were observed with hinokiflavone ( 4), but podocarpusflavone A ( 2) is the strongest noncytotoxic inhibitor of the DV-NS5 and it also displayed polymerase inhibitory activity in a DV replicon.
    CONCLUSIONS:
    A preliminary structure-activity relationship study (SARs) revealed the necessity of the biflavonoid skeleton, the influence of number and position of methoxylations, and the importance of a free rotation of the linkage between the two apigenin monomers of the biflavonoids. To the best of our knowledge, podocarpusflavone A ( 2) is the strongest noncytotoxic non-nucleotide molecule exhibiting a specific inhibitory activity against the RNA polymerase domain of DV-NS5 and thus is promising for chemotherapy development against dengue fever.
    Ann Trop Med Parasitol. 2007 Jan;101(1):23-30.
    Antimalarial and vasorelaxant constituents of the leaves of Allanblackia monticola (Guttiferae).[Pubmed: 17244407 ]

    METHODS AND RESULTS:
    Phytochemical investigation of the leaves of Allanblackia monticola led to the isolation and characterisation of five prenylated xanthones [1,6-dihydroxy-3,7-dimethoxy-2-(3-methylbut-2-enyl)xanthone 1, alpha-mangostin 2, tovophyllin A 3, allanxanthone C 4 and 1,7-dihydroxy-3-methoxy-2-(3-methylbut-2-enyl)xanthone 5], two biflavonoid derivatives (amentoflavone 6 and Podocarpusflavone A 7) and one pentacyclic triterpene (friedelan-3-one 8). The structures of these compounds were established on the basis of homo- and hetero-nuclear, one- and two-dimensional, nuclear magnetic resonance. Compounds 2-8 and a crude methanolic extract of A. monticola leaves were each tested for antimalarial activity in vitro, using the chloroquine-sensitive F32 and chloroquine-resistant FcM29 strains of Plasmodium falciparum; the median inhibitory concentrations (IC(50)) recorded varied from 0.7 to 83.5 mug/ml. The cytotoxicities of the compounds and crude extract, against cultures of human melanoma cells (A375), were then investigated, and cytotoxicity/antimalarial IC(50) ratios of 0.6-16.75 were recorded.
    CONCLUSIONS:
    In tests involving aortic rings from guinea pigs, a crude extract of the leaves of A. monticola was found to induce concentration-dependent vasorelaxation, causing up to 82% and 42% inhibition of noradrenaline- and KCl-induced contractions, respectively. The corresponding values for compounds 2 and 6 when tested against noradrenaline-induced contractions were approximately 18% and 35%, respectively.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.81 mL 9.0498 mL 18.0995 mL 36.1991 mL 45.2489 mL
    5 mM 0.362 mL 1.81 mL 3.6199 mL 7.2398 mL 9.0498 mL
    10 mM 0.181 mL 0.905 mL 1.81 mL 3.6199 mL 4.5249 mL
    50 mM 0.0362 mL 0.181 mL 0.362 mL 0.724 mL 0.905 mL
    100 mM 0.0181 mL 0.0905 mL 0.181 mL 0.362 mL 0.4525 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7-去甲基银杏双黄酮; Bilobetin CFN98846 521-32-4 C31H20O10 = 552.5 20mg QQ客服:2056216494
    红杉双黄酮; Sequoiaflavone CFN95642 21763-71-3 C31H20O10 = 552.5 5mg QQ客服:215959384
    苏铁双黄酮; Sotetsuflavone CFN93257 2608-21-1 C31H20O10 = 552.5 5mg QQ客服:1413575084
    银杏素; Ginkgetin CFN90173 481-46-9 C32H22O10 = 566.51 20mg QQ客服:2056216494
    罗汉松黄酮A; Podocarpusflavone A CFN98202 22136-74-9 C31H20O10 = 552.5 5mg QQ客服:2159513211
    竹柏双黄酮B; Putraflavone CFN98246 23624-21-7 C32H22O10 = 566.5 5mg QQ客服:2159513211
    三叶橡胶黄酮; Heveaflavone CFN98236 23132-13-0 C33H24O10 = 580.6 5mg QQ客服:215959384
    异银杏双黄酮; Isoginkgetin CFN90174 548-19-6 C32H22O10 = 566.51 20mg QQ客服:2159513211
    金松双黄酮; Sciadopitysin CFN98847 521-34-6 C33H24O10 = 580.6 20mg QQ客服:215959384
    7''-O-甲氧基金松双黄酮; 7''-O-Methylsciadopitysin CFN96118 3778-25-4 C34H26O10 = 594.6 5mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产