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  • 松柏酸

    Pinusolidic acid

    松柏酸
    产品编号 CFN98634
    CAS编号 40433-82-7
    分子式 = 分子量 C20H28O4 = 332.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The leaves of Platycladus orientalis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    松柏酸 CFN98634 40433-82-7 1mg QQ客服:215959384
    松柏酸 CFN98634 40433-82-7 5mg QQ客服:215959384
    松柏酸 CFN98634 40433-82-7 10mg QQ客服:215959384
    松柏酸 CFN98634 40433-82-7 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Amsterdam (Netherlands)
  • Universite de Lille1 (France)
  • Copenhagen University (Denmark)
  • Charles University in Prague (Czech Republic)
  • University of Minnesota (USA)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • University of Auckland (New Zealand)
  • Sant Gadge Baba Amravati University (India)
  • Subang Jaya Medical Centre (Malaysia)
  • Helmholtz Zentrum München (Germany)
  • University of Oslo (Norway)
  • Monash University Malaysia (Malaysia)
  • FORTH-IMBB (Greece)
  • Charles Sturt University (Denmark)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2019, 24(12):E2286
  • Antioxidants (Basel).2020, 9(2): E119
  • J Food Biochem.2020, 44(6):e13198.
  • Polytechnic University of Catalonia2017, 105826
  • Int Immunopharmacol. 2020, 83:106403.
  • Molecules.2023, 28(7):3039.
  • Plants (Basel).2020, 9(11):1535.
  • Phytomedicine.2020, 153440.
  • J Biol Chem.2014, 289(3):1723-31
  • Plants (Basel).2022, 11(21):2947.
  • Int J Mol Sci.2018, 19(9):E2601
  • Phytomedicine.2021, 2(82):153452
  • Journal of functional foods2018, 171-182
  • Metabolites.2020, 10(12):497.
  • Phytother Res.2015, 29(7):1088-96
  • Turk J Med Sci.2023 53: 1312-1320.
  • RSC Advances2017, 86
  • Exp Ther Med.2019, 18(6):4388-4396
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • Tea Res. Ins. Of China2017, 1-12
  • Sci Rep.2018, 8:9267
  • Nutrients.2020, 12(12):3607.
  • Institute of Food Science & Technology2021, 56(11).
  • ...
  • 生物活性
    Description: Pinusolidic acid shows a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 micrograms/ml).
    Targets: PAFR
    In vitro:
    Planta Med. 1998 Feb;64(1):72-4.
    Pinusolidic acid: a platelet-activating factor inhibitor from Biota orientalis.[Pubmed: 9491770 ]

    METHODS AND RESULTS:
    The water extract of Biota orientalis showed a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets using [3H]PAF as a ligand in our previous screening studies for Korean medicinal antagonists by the activity-guided purification studies. Another active compound, compound 1 (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 micrograms/ml, n = 4) was isolated from the title plant.
    CONCLUSIONS:
    The chemical structure of compound 1 was elucidated as pinusolidic acid by chemical and spectrometric analyses.
    J Nat Prod. 2006 Apr;69(4):689-91.
    Neuroprotective diterpenes from the fruiting body of Antrodia camphorata.[Pubmed: 16643055]

    METHODS AND RESULTS:
    Three new compounds, 19-hydroxylabda-8(17)-en-16,15-olide (1), 3beta,19-dihydroxylabda-8(17),11E-dien-16,15-olide (2), and 13-epi-3beta,19-dihydroxylabda-8(17),11E-dien-16,15-olide (3), together with four known compounds, 19-hydroxylabda-8(17),13-dien-16,15-olide (4), 14-deoxy-11,12-didehydroandrographolide (5), 14-deoxyandrographolide, and Pinusolidic acid, were isolated from the fruiting bodies of Antrodia camphorata. The structures of compounds 1-3 were elucidated by the analysis of their spectroscopic data.
    CONCLUSIONS:
    The in vitro neuroprotective activity of all compounds was evaluated, and compounds 1-5 protected neurons from Abeta damage by 39.2, 35.0, 36.7, 30.6, and 27.0%, respectively, at concentrations between 5 and 20 microM.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0084 mL 15.0421 mL 30.0842 mL 60.1685 mL 75.2106 mL
    5 mM 0.6017 mL 3.0084 mL 6.0168 mL 12.0337 mL 15.0421 mL
    10 mM 0.3008 mL 1.5042 mL 3.0084 mL 6.0168 mL 7.5211 mL
    50 mM 0.0602 mL 0.3008 mL 0.6017 mL 1.2034 mL 1.5042 mL
    100 mM 0.0301 mL 0.1504 mL 0.3008 mL 0.6017 mL 0.7521 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    16-羟基-8(17),13-赖百当二烯-15,16-内酯-19-酸; 16-Hydroxy-8(17),13-labdadien-15,16-olid-19-oic acid CFN97177 691009-85-5 C20H28O5 = 348.4 5mg QQ客服:2159513211
    松柏酸; Pinusolidic acid CFN98634 40433-82-7 C20H28O4 = 332.4 5mg QQ客服:2159513211
    红松内酯; Pinusolide CFN98404 31685-80-0 C21H30O4 = 346.5 10mg QQ客服:1413575084
    19-[(beta-D-glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide; 19-[(beta-D-glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide CFN97481 919120-78-8 C26H38O9 = 494.6 5mg QQ客服:1413575084
    15-甲氧基松柏酸; 15-Methoxypinusolidic acid CFN97253 769928-72-5 C21H30O5 = 362.5 5mg QQ客服:1413575084

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