球松素查尔酮

Pinostrobin chalcone

	产品编号	CFN99878
	CAS编号	18956-15-5
	分子式 = 分子量	C₁₆H₁₄O₄ = 270.3
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Chalcones
	植物来源	The heartwoods of Lindera umbellata.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
球松素查尔酮	CFN99878	18956-15-5	10mg	QQ客服：215959384
球松素查尔酮	CFN99878	18956-15-5	20mg	QQ客服：215959384
球松素查尔酮	CFN99878	18956-15-5	50mg	QQ客服：215959384
球松素查尔酮	CFN99878	18956-15-5	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Sri Ramachandra University (India)

Universidad de Buenos Aires (Argentina)

Complutense University of Madrid (Spain)

National Cancer Institute (USA)

Georgia Institute of Technology (USA)

Cornell University (USA)

Mahidol University (Thailand)

University of Parma (Italy)

Monash University Sunway Campus (Malaysia)

Universite de Lille1 (France)

Wageningen University (Netherlands)

The Institute of Cancer Research (United Kingdom)

Vin?a Institute of Nuclear Sciences (Serbia)

Medical University of South Carolina (USA)

More...

Description:

Pinostrobin chalcone is a potent inhibitor of triglyceride accumulation, it can inhibit adipogenesis in 3T3-L1 cells, it may have anti-obesity effects through the inhibition of adipogenesis. Pinostrobin chalcone displays very remarkable cytotoxic activity against the human cancer cells, such as KB, MCF7 and Caski cells (IC50 values of 6.2, 7.3 and 7.7 ug/mL, respectively).

Targets:

Fatty Acid Synthase

In vitro:

J Nat Med. 2016 Jul;70(3):502-9.

Inhibitory effects of compounds isolated from the dried branches and leaves of murta (Myrceugenia euosma) on lipid accumulation in 3T3-L1 cells.[Pubmed: 26880616 ]

As obesity is a global health concern the demand for anti-obesity drugs is high. In this study, we investigated the anti-obesity effect of the dried branches and leaves of murta (Myrceugenia euosma Legrand, Myrtaceae).
METHODS AND RESULTS:
A methanol extract of the dried branches and leaves of murta inhibited adipogenesis in 3T3-L1 cells. Three known flavanones-cryptostrobin (1), pinocembrin (4), and 5,7-dihydroxy-6,8-dimethylflavanone (6), and three chalcones-2',6'-dihydroxy-3'-methyl-4'-methoxychalcone (2), Pinostrobin chalcone (3), and 2',6'-dihydroxy-4'-methoxy-3',5'-dimethylchalcone (5) were isolated from the active fraction. Structures of these compounds were identified using various spectral data. Each of these compounds also inhibited adipogenesis in 3T3-L1 cells. In particular, compound 3 was a more potent inhibitor of triglyceride accumulation than the positive control berberine. Gene expression studies revealed that treatment of 3T3-L1 cells with 3 lowers the expression levels of CCAAT/enhancer-binding protein α and peroxisome proliferator activator γ2 during adipogenesis without affecting cell viability. Treatment of 3T3-L1 cells with 3 reduced the expression levels of mRNAs encoding sterol regulatory element-binding protein 1c and several lipogenic enzymes, including fatty acid synthase and stearoyl CoA desaturase-1.
CONCLUSIONS:
These results indicate that the methanol extract and compounds isolated from the dried branches and leaves of murta exert their anti-obesity effects through the inhibition of adipogenesis.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
2'-羟基-3',4',6'-三甲氧基查尔酮; 2'-Hydroxy-3',4',6'-trimethoxychalcone	CFN91489	91856-16-5	C₁₈H₁₈O₅ = 314.3	5mg	QQ客服：1457312923
瓜馥木甲素B，2',5'- 二羟基-3',4',6'-三甲氧基二氢查尔酮; Dihydropedicin	CFN97805	169234-89-3	C₁₈H₂₀O₆ = 332.35	5mg	QQ客服：215959384
柄苣素; Pedicin	CFN97978	521-51-7	C₁₈H₁₈O₆ = 330.3	5mg	QQ客服：2159513211
2',6'-二羟基4'-甲氧基二氢查耳酮; 2',6'-Dihydroxy 4'-methoxydihydrochalcone	CFN70346	35241-55-5	C₁₆H₁₆O₄ = 272.3	5mg	QQ客服：215959384
球松素查尔酮; Pinostrobin chalcone	CFN99878	18956-15-5	C₁₆H₁₄O₄ = 270.3	20mg	QQ客服：1413575084
小豆蔻明; Cardamonin	CFN99890	19309-14-9	C₁₆H₁₄O₄ = 270.3	20mg	QQ客服：1413575084
黄卡瓦胡椒素B; Flavokawain B	CFN92661	1775-97-9	C₁₇H₁₆O₄ = 284.3	20mg	QQ客服：1413575084
二氢帕夏查耳酮; Dihydropashanone	CFN97741	41997-41-5	C₁₇H₁₈O₅ = 302.33	5mg	QQ客服：2056216494
帕夏查耳酮; Pashanone	CFN98661	42438-78-8	C₁₇H₁₆O₅ = 300.3	5mg	QQ客服：2056216494
1-(2,4-二羟基-3,6-二甲氧基苯基)-3-苯基-1-丙酮; 2',4'-Dihydroxy-3',6'-dimethoxydihydrochalcone	CFN98908	54299-52-4	C₁₇H₁₈O₅ = 302.3	5mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.6996 mL	18.498 mL	36.9959 mL	73.9919 mL	92.4898 mL
5 mM	0.7399 mL	3.6996 mL	7.3992 mL	14.7984 mL	18.498 mL
10 mM	0.37 mL	1.8498 mL	3.6996 mL	7.3992 mL	9.249 mL
50 mM	0.074 mL	0.37 mL	0.7399 mL	1.4798 mL	1.8498 mL
100 mM	0.037 mL	0.185 mL	0.37 mL	0.7399 mL	0.9249 mL