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  • 叶下珠新素

    Phyltetralin

    叶下珠新素
    产品编号 CFN92069
    CAS编号 123048-17-9
    分子式 = 分子量 C24H32O6 = 416.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The herbs of Phyllanthus niruri Linn.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    叶下珠新素 CFN92069 123048-17-9 1mg QQ客服:1413575084
    叶下珠新素 CFN92069 123048-17-9 5mg QQ客服:1413575084
    叶下珠新素 CFN92069 123048-17-9 10mg QQ客服:1413575084
    叶下珠新素 CFN92069 123048-17-9 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Florida International University (USA)
  • Periyar University (India)
  • University of Eastern Finland (Finland)
  • Srinakharinwirot University (Thailand)
  • Medical University of Gdansk (Poland)
  • University of Beira Interior (Portugal)
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  • Aveiro University (Portugal)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Applied Biological Chemistry2023, 66:85.
  • BMC Complement Med Ther.2023, 23(1):264.
  • Antibiotics.2022, 11(4), 510.
  • Horticulturae2020, 6(4),76.
  • Biomolecules.2022, 12(12):1754.
  • J Nat Med.2017, 71(2):457-462
  • Korean Journal of Pharmacognosy2014, 113-120
  • J Med Food.2021, 24(2):151-160.
  • J Agric Food Chem.2022, 70(51):16176-16187.
  • Molecules.2019, 24(10):E1926
  • Korean J. Medicinal Crop Sci.2018, 26(2):148-156
  • BMC Complement Altern Med.2018, 18(1):303
  • Am J Chin Med.2015, 30:1-22
  • Drug Dev Res.2020, doi: 10.1002
  • ACS Omega.2022, 7(44):40009-40020.
  • Int J Mol Sci.2022, 23(13):7115.
  • Int J Mol Sci.2021, 22(9):5012.
  • J Enzyme Inhib Med Chem.2019, 34(1):134-143
  • J Agric Food Chem.2018, 66(1):351-358
  • Korean J. Food Preserv.2023, 30(4):663-668.
  • Food and Chemical Toxicology2020, 111221
  • J Pharm Biomed Anal.2017, 140:274-280
  • J Ethnopharmacol.2017, 198:91-97
  • ...
  • 生物活性
    Description: Phyltetralin has antihyperuricemic activity.
    Targets: Immunology & Inflammation related
    In vitro:
    J Ethnopharmacol. 2008 Mar 5;116(2):333-40.
    Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria.[Pubmed: 18187278]

    METHODS AND RESULTS:
    Phyllanthus urinaria Linnea (Euphorbiaceae), is a traditional anti-hepatitis herb used in Taiwan. In continuation of our search for potent natural anti-inflammatory agents, from the ethanolic extract of this plant, nine compounds including phyllanthin (1), Phyltetralin (2), trimethyl-3,4-dehydrochebulate (3), methylgallate (4), and rhamnocitrin (5), methyl brevifolincarboxylate (6), beta-sitosterol-3-O-beta-d-glucopyranoside (7), quercitrin (8), and rutin (9) were isolated.
    CONCLUSIONS:
    The structures of compounds 3 and 6 were established based on NMR and mass spectral studies. The isolates 1-9 were investigated for their antioxidant, and anti-inflammatory activities in vitro.
    In vivo:
    Planta Med. 2006 Nov;72(14):1262-7. Epub 2006 Sep 1.
    Antihyperuricemic lignans from the leaves of Phyllanthus niruri.[Pubmed: 16953466]

    METHODS AND RESULTS:
    The methanol extract from the leaves of Phyllanthus niruri L. showed oral antihyperuricemic activity in potassium oxonate- and uric acid-induced hyperuricemic rats. Fractionation of the extract by resin chromatography led to the isolation of a less polar fraction which exhibited the highest reduction of plasma uric acid. Further antihyperuricemic-guided purification of the fraction afforded three lignans, phyllanthin (1), hypophyllanthin (2) and phyltetralin (3), of which 1 significantly reversed the plasma uric acid level of hyperuricemic animals to its normal level in a dose-dependent manner, comparable to that of allopurinol, benzbromarone and probenecid which are used clinically for the treatment of hyperuricemia and gout.
    CONCLUSIONS:
    Thus, the lignans of P. niruri are potential antihyperuricemic agents worthy of further investigation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.401 mL 12.0048 mL 24.0096 mL 48.0192 mL 60.024 mL
    5 mM 0.4802 mL 2.401 mL 4.8019 mL 9.6038 mL 12.0048 mL
    10 mM 0.2401 mL 1.2005 mL 2.401 mL 4.8019 mL 6.0024 mL
    50 mM 0.048 mL 0.2401 mL 0.4802 mL 0.9604 mL 1.2005 mL
    100 mM 0.024 mL 0.12 mL 0.2401 mL 0.4802 mL 0.6002 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5-甲氧基异落叶松脂素 ; 5-Methoxyisolariciresinol CFN96710 136082-41-2 C21H26O7 = 390.43 5mg QQ客服:3257982914
    Spathulatol ; Spathulatol CFN96566 1373888-27-7 C30H34O9 = 538.59 5mg QQ客服:2159513211
    Cagayanin; Cagayanin CFN95480 99096-51-2 C42H50O10 = 714.9 20mg QQ客服:3257982914
    愈创木素; Guaiacin CFN97039 36531-08-5 C20H24O4 = 328.4 5mg QQ客服:1413575084
    五脂素A1; Wulignan A1 CFN99005 117047-76-4 C20H22O5 = 342.4 5mg QQ客服:1457312923
    Arisantetralone B; Arisantetralone B CFN95211 1161947-96-1 C20H22O5 = 342.4 5mg QQ客服:2056216494
    五味子酮; Schisandrone CFN92351 98619-25-1 C21H24O5 = 356.4 10mg QQ客服:2159513211
    表华中五味子酮; Epischisandrone CFN95212 98619-26-2 C21H24O5 = 356.4 5mg QQ客服:2056216494
    (-)-Holostyligone; (-)-Holostyligone CFN90734 887501-28-2 C21H24O5 = 356.41 5mg QQ客服:1457312923
    二甲基五脂素A1; Dimethylwulignan A1 CFN92718 117404-43-0 C22H26O5 = 370.4 5mg QQ客服:215959384

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