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  • 根皮苷

    Phlorizin

    根皮苷
    产品编号 CFN97038
    CAS编号 60-81-1
    分子式 = 分子量 C21H24O10 = 436.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Chalcones
    植物来源 The herbs of Prunus armeniaca L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    根皮苷 CFN97038 60-81-1 10mg QQ客服:1413575084
    根皮苷 CFN97038 60-81-1 20mg QQ客服:1413575084
    根皮苷 CFN97038 60-81-1 50mg QQ客服:1413575084
    根皮苷 CFN97038 60-81-1 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Evid Based Complement Alternat Med.2016, 2016:1739760
  • Nat Prod Sci.2019, 25(3):238
  • Sci Rep.2019, 9(1):4646
  • J Bone Miner Res.2017, 32(12):2415-2430
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  • Univerzita Karlova2022, 173245.
  • Curr Issues Mol Biol.2022, 44(5):2300-2308.
  • Sci Adv.2018, 4(10)
  • Exp Mol Med.2020, 52(4):629-642.
  • Molecules. 2013, 18(11):14105-21
  • Appl. Sci.2020, 10(5),1713.
  • Nutrients.2018, 10(12):E1998
  • J Nutr Biochem.2022, 107:109064.
  • J Liq Chromatogr R T2018, 41(12):761-769
  • Food Chem.2019, 278:683-691
  • Molecules.2020 ,25(16):3697.
  • Am J Chin Med.2022, 1-20.
  • ...
  • 生物活性
    Description: Phlorizin is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor. Phlorizin may be a novel therapeutic approach for the treatment of diabetic nephrolog, it protects mice from diabetic nephrology. Phlorizin prevents ventricular tachyarrhythmia through the improvement of impulse conduction slowing during ischemia.
    Targets: TNF-α | hSGLT1 | hSGLT2 | ATPase | Sodium Channel | Calcium Channel
    In vitro:
    Am J Physiol Renal Physiol. 2014 Jun 15;306(12):F1520-33.
    Competitive inhibition of SGLT2 by tofogliflozin or phlorizin induces urinary glucose excretion through extending splay in cynomolgus monkeys.[Pubmed: 24761001]
    Sodium-glucose cotransporter 2 (SGLT2) inhibitors showed a glucose lowering effect in type 2 diabetes patients through inducing renal glucose excretion. Detailed analysis of the mechanism of the glucosuric effect of SGLT2 inhibition, however, has been hampered by limitations of clinical study.
    METHODS AND RESULTS:
    Here, we investigated the mechanism of urinary glucose excretion using nonhuman primates with SGLT inhibitors tofogliflozin and phlorizin, both in vitro and in vivo. In cells overexpressing cynomolgus monkey SGLT2 (cSGLT2), both tofogliflozin and phlorizin competitively inhibited uptake of the substrate (α-methyl-d-glucopyranoside; AMG). Tofogliflozin was found to be a selective cSGLT2 inhibitor, inhibiting cSGLT2 more strongly than did phlorizin, with selectivity toward cSGLT2 1,000 times that toward cSGLT1; phlorizin was found to be a nonselective cSGLT1/2 inhibitor. In a glucose titration study in cynomolgus monkeys under conditions of controlled plasma drug concentration, both tofogliflozin and phlorizin increased fractional excretion of glucose (FEG) by up to 50% under hyperglycemic conditions. By fitting the titration curve using a newly introduced method that avoids variability in estimating the threshold of renal glucose excretion, we found that tofogliflozin and phlorizin lowered the threshold and extended the splay in a dose-dependent manner without significantly affecting the tubular transport maximum for glucose (TmG).
    CONCLUSIONS:
    Our results demonstrate the contribution of SGLT2 to renal glucose reabsorption (RGR) in cynomolgus monkeys and demonstrate that competitive inhibition of cSGLT2 exerts a glucosuric effect by mainly extending splay and lowering threshold without affecting TmG.
    In vivo:
    J Diabetes Complications. 2014 Sep-Oct;28(5):596-603.
    Beneficial effects of phlorizin on diabetic nephropathy in diabetic db/db mice.[Pubmed: 24927646]
    This study observes the effects of phlorizin on diabetic nephrology in db/db diabetic mice and explores possible underlying mechanisms.
    METHODS AND RESULTS:
    Sixteen diabetic db/db mice and eight age-matched db/m mice were divided into three groups: vehicle-treated diabetic group (DM group), diabetic group treated with phlorizin (DMT group) and normal control group (CC group). Phlorizin was given in normal saline solution by intragastric administration for 10 weeks. Differentially expressed proteins in three groups were identified using iTRAQ quantitative proteomics and the data were further analyzed with ingenuity pathway analysis. The body weight and serum concentrations of fasting blood glucose (FBG), advanced glycation end products (AGEs), total cholesterol, triglycerides, blood urea nitrogen, creatinine and 24-h urine albumin were increased in the DM group compared to those of the CC group (P<0.05), and they were decreased by treatment with phlorizin (P<0.05). Morphologic observations showed phlorizin markedly attenuated renal injury. Phlorizin prevented diabetic nephropathy by regulating the expression of a series of proteins involved in renal and urological disease, molecular transport, free radical scavenging, and lipid metabolism.
    CONCLUSIONS:
    Phlorizin protects mice from diabetic nephrology and thus may be a novel therapeutic approach for the treatment of diabetic nephrology.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2915 mL 11.4574 mL 22.9148 mL 45.8295 mL 57.2869 mL
    5 mM 0.4583 mL 2.2915 mL 4.583 mL 9.1659 mL 11.4574 mL
    10 mM 0.2291 mL 1.1457 mL 2.2915 mL 4.583 mL 5.7287 mL
    50 mM 0.0458 mL 0.2291 mL 0.4583 mL 0.9166 mL 1.1457 mL
    100 mM 0.0229 mL 0.1146 mL 0.2291 mL 0.4583 mL 0.5729 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    地奥司明杂质5; Diosmin Impurity 5 CFN95311 122087-66-5 C30H38O15 = 638.6 10mg QQ客服:1457312923
    二氢马里苷; Dihydromarein CFN90853 N/A C21H24O11 = 452.4 5mg QQ客服:1413575084
    马里苷; Marein CFN90851 535-96-6 C21H22O11 = 450.4 10mg QQ客服:1413575084
    新异甘草苷; Neoisoliquiritin CFN90823 59122-93-9 C21H22O9 = 418.4 10mg QQ客服:1413575084
    异甘草苷; Isoliquiritin CFN99155 5041-81-6 C21H22O9 = 418.39 20mg QQ客服:215959384
    芹糖异甘草苷; Isoliquiritin apioside CFN90800 120926-46-7 C26H30O13 = 550.5 20mg QQ客服:3257982914
    弗罗利辛二水合物; Phlorizin dihydrate CFN90442 7061-54-3 C21H24O10.2H2O = 472.44 20mg QQ客服:2056216494
    Asebotin; Asebotin CFN96929 11075-15-3 C22H26O10 = 450.44 5mg QQ客服:3257982914
    三叶甙; Trilobatin CFN98658 4192-90-9 C21H24O10 = 436.4 20mg QQ客服:3257982914
    三叶甙2''-乙酸酯; Trilobatin 2''-acetate CFN97111 647853-82-5 C23H26O11 = 478.5 5mg QQ客服:2159513211

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