| In vitro: |
| Phytother Res. 2012 Jul;26(7):964-8. | | Lignans with anti-hepatitis B virus activities from Phyllanthus niruri L.[Pubmed: 22131154] | One new lignan, Nirtetralin B, along with its two known stereoisomers were isolated from Phyllanthus niruri L.
METHODS AND RESULTS:
The structure of the new compound was determined by spectroscopy experiments and x-ray diffraction analysis.
These lignans were assayed for anti-hepatitis B virus activities in vitro. Nirtetralin and Nirtetralin A, B effectively suppressed the secretion of the HBV antigens in a dose-dependent manner with IC₅₀ values for HBsAg of 9.5 µM (Nirtetralin A), 16.7 µM (Nirtetralin B) and 97.2 µM (Nirtetralin), IC₅₀ values for HBeAg of 17.4 µM (Nirtetralin A), 69.3 µM (Nirtetralin B) and 232.0 µM (Nirtetralin), respectively. | | Phytother Res. 2003 May;17(5):449-53. | | Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro.[Pubmed: 12748977 ] |
CONCLUSIONS:
Using an HBV-producing cell line and inhibition of the expression of the HBsAg and HBeAg as antiviral indicators, a study was conducted on 25 compounds isolated from four Phyllanthus (Euphorbiaceae) plants, including P. amarus Schum. & Thonn., P. multi florus Willd., P. tenellus Roxb. and P. virgatus Forst. f. It was found that niranthin (1), nirtetralin (3), hinokinin (5) and geraniin (13) at the non-cytotoxic concentration of 50 micro m, suppressed effectively both HBsAg and HBeAg expression, with the highest inhibition at 74.3%, 45.3%; 69.6%, 33.9%; 68.1%, 52.3%; 32.1%, 46.6%, respectively.
CONCLUSIONS:
Of these, niranthin (1) showed the best anti-HBsAg activity, while the most potent anti-HBeAg activity was observed with hinokinin (5). |
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