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  • 印苦楝内酯

    Nimbolide

    印苦楝内酯
    产品编号 CFN91919
    CAS编号 25990-37-8
    分子式 = 分子量 C27H30O7 = 466.52
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The barks of Azadirachta indica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    印苦楝内酯 CFN91919 25990-37-8 1mg QQ客服:2159513211
    印苦楝内酯 CFN91919 25990-37-8 5mg QQ客服:2159513211
    印苦楝内酯 CFN91919 25990-37-8 10mg QQ客服:2159513211
    印苦楝内酯 CFN91919 25990-37-8 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Kyung Hee University (Korea)
  • Deutsches Krebsforschungszentrum (Germany)
  • University of Illinois (USA)
  • Harvard University (USA)
  • University of Vigo (Spain)
  • Michigan State University (USA)
  • Medical University of South Carolina (USA)
  • Srinakharinwirot University (Thailand)
  • University of Virginia (USA)
  • Osmania University (India)
  • FORTH-IMBB (Greece)
  • University of Minnesota (USA)
  • Mendel University in Brno (Czech Republic)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pak J Pharm Sci.2018, 31:311-315
  • Bio-protocol2018, 9(14):e3301
  • Sci Rep.2021, 11(1):11936.
  • Nat Prod Commun.2018, 10.1177
  • Analytical Methods2018, 10(27)
  • Chem Pharm Bull (Tokyo).2017, 65(9):826-832
  • Dent Mater J.2020, 39(4):690-695
  • Int J Mol Sci.2018, 19(9):E2825
  • Nutr Res Pract.2023, 17(4):670-681.
  • Eur J Pharmacol.2021, 906:174220.
  • Asian J Beauty Cosmetol2020, 18(3): 265-272.
  • Biochem Systematics and Ecology2017, 11-18
  • Biomol Ther (Seoul).2019, 10.4062
  • Appl. Sci. 2021, 11(22),10569
  • Inflammation.2015, 38(4):1502-16
  • mBio.2020, 11(3):e00686-20.
  • Molecules.2019, 24(11):E2102
  • Plants (Basel).2021, 10(7):1376.
  • J Immunol.2023, ji2200727.
  • J Pharm Biomed Anal.2019, 172:268-277
  • Korean Herb. Med. Inf.2020, 8(2):205-213
  • Food and Chemical Toxicology2020, 111221
  • Phytomedicine.2022, 99:153997.
  • ...
  • 生物活性
    Description: Nimbolide is a more potent antiproliferative and apoptosis inducing agent and offers promise as a candidate agent in multitargeted prevention and treatment of cancer; it can sensitize tumor cells to chemotherapeutic agents through interaction with IKK, leading to inhibition of NF-κB-regulated proteins. Nimbolide attenuates the lipid accumulation, oxidative stress and antioxidant in primary hepatocytes. Nimbolide also has antibacterial potential.
    Targets: Bcl-2/Bax | Caspase | p53 | P450 (e.g. CYP17) | PARP | NF-kB | MMP(e.g.TIMP) | VEGFR | IkB | EGFR | PPAR | Liver X Receptor | Antifection | IKK
    In vitro:
    Cell Prolif. 2014 Dec;47(6):540-52.
    Nimbolide inhibits invasion and migration, and down-regulates uPAR chemokine gene expression, in two breast cancer cell lines.[Pubmed: 25377085]
    Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in women, worldwide. Urokinase type plasminogen activator (uPA) is a serine protease that is involved in cancer progression, especially invasion and metastasis of breast cancer. Nimbolide is a potent cytotoxic limnoid isolated from Azadirachta indica. Our previous studies have shown that Nimbolide elicits pleiotropic effects on breast cancer cells; however, its roles in invasion and migration have not previously been fully elucidated.
    METHODS AND RESULTS:
    Protein expression of pEGFR, VEGFR, NFκB, IKKα, IKKβ, MMP-2, MMP-9 and TIMP-2 were analysed by western blotting. We also analysed expressions of uPA, uPAR genes and chemokines by real-time PCR. Breast cancer cell invasion was assessed by transwell invasion assay and cell migration analysed by scratch wound healing assay. Our results showed that reduced protein expression of pEGFR, VEGFR, NFκB, IKKα, β, MMP-2, MMP-9 and TIMP-2 was higher in Nimbolide-treated breast cancer cells. mRNA expression of uPA, uPAR, chemokines and their receptors were also significantly reduced in response to Nimbolide treatment. Nimbolide inhibited breast cancer cell migration and invasion as shown in transwell invasion and wound healing assays.
    CONCLUSIONS:
    These results clearly proved inhibitory effects of Nimbolide on tumour cell invasion and migration by down-regulating proteins critically involved in regulation of cell invasion and metastasis, suggesting a possible therapeutic role of Nimbolide for breast cancer.
    International Journal of Pharmacy & Pharmaceutical Sciences, 2014, 6(5):636-638.
    Antibacterial potential of Nimbolide from Azadirachta indica[Reference: WebLink]
    The present study was designed to evaluate the antibacterial activity of the isolated Nimbolide compound from Azadirachta indica.
    METHODS AND RESULTS:
    Antibacterial potential of the isolated Nimbolide compound of Azadirachta indica plants was screened by disc diffusion assay against Bacillus subtilis, Enterococcus faecalis, Streptococcus epidermis, Enterobacter aerogene, Enterobacter cloacae, and Salmonella typhimurium. Ciprofloxacin is used as standards for bacteria. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of Nimbolide compound was determined using the macro dilution method. The antibacterial potency of Nimbolide compound from Azadirachta indica was assessed by their zone of inhibition values. Nimbolide showed satisfactory results against almost all the organisms, among them against Salmonella typhimurium and Bacillus subtilis showed highest zone of inhibition 18.1 mm and 17.3 mm (0.4mg/ml) with the MIC values of 0.078 mg/ml and MBC values of 0.156 mg/ml. Other pathogens like Streptococcus epidermis, Enterococcus faecalis showed good zone of inhibition 13.2 mm and 11.8 mm (0.4mg/ml). But Enterobacter cloacae was found to be resistant with more MIC, more MBC value and with a very less zone of inhibition of 8.5 mm (0.4mg/ml) when compared with the standards (Ciprofloxacin).
    CONCLUSIONS:
    The present investigations revealed that Nimbolide have significant antibacterial activity. So, the potent antibacterial agent Nimbolide is preferred for infectious disease.
    In vivo:
    Invest New Drugs. 2010 Aug;28(4):392-401.
    The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis.[Pubmed: 19458912]
    Limonoids from the neem tree (Azadirachta indica) have attracted considerable research attention for their cytotoxicity against human cancer cell lines. However, the antiproliferative and apoptosis inducing effects of neem limonoids have not been tested in animal tumour models.
    METHODS AND RESULTS:
    The present study was therefore designed to evaluate the relative chemopreventive potential of the neem limonoids azadirachtin and Nimbolide in the hamster buccal pouch (HBP) carcinogenesis model by analyzing the expression of proliferating cell nuclear antigen (PCNA), p21(waf1), cyclin D1, glutathione S-transferase pi (GST-P), NF-kappaB, inhibitor of kappaB (IkappaB), p53, Fas, Bcl-2, Bax, Bid, Apaf-1, cytochrome C, survivin, caspases-3, -6, -8 and -9, and poly(ADP-ribose) polymerase (PARP) by RT-PCR, immunohistochemical, and Western blot analyses.
    CONCLUSIONS:
    The results provide compelling evidence that azadirachtin and Nimbolide mediate their antiproliferative effects by downregulating proteins involved in cell cycle progression and transduce apoptosis by both the intrinsic and extrinsic pathways. On a comparative basis, Nimbolide was found to be a more potent antiproliferative and apoptosis inducing agent and offers promise as a candidate agent in multitargeted prevention and treatment of cancer.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1435 mL 10.7177 mL 21.4353 mL 42.8706 mL 53.5883 mL
    5 mM 0.4287 mL 2.1435 mL 4.2871 mL 8.5741 mL 10.7177 mL
    10 mM 0.2144 mL 1.0718 mL 2.1435 mL 4.2871 mL 5.3588 mL
    50 mM 0.0429 mL 0.2144 mL 0.4287 mL 0.8574 mL 1.0718 mL
    100 mM 0.0214 mL 0.1072 mL 0.2144 mL 0.4287 mL 0.5359 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    印苦楝内酯; Nimbolide CFN91919 25990-37-8 C27H30O7 = 466.52 10mg QQ客服:215959384
    2,3-二氢-3alpha-甲氧基印苦楝内酯; 2,3-Dihydro-3alpha-methoxynimbolide CFN96791 1607828-35-2 C28H34O8 = 498.57 5mg QQ客服:1413575084
    脱乙酰基印楝素; Deacetylnimbin CFN97797 18609-16-0 C28H34O8 = 498.57 5mg QQ客服:2159513211
    印楝素; Nimbin CFN97722 5945-86-8 C30H36O9 = 540.61 5mg QQ客服:3257982914
    2'-3'-dehydrosalannol; 2',3'-Dehydrosalannol CFN97589 97411-50-2 C32H42O8 = 554.68 5mg QQ客服:215959384
    去乙酰印楝沙兰林; Deacetylsalannin CFN97855 1110-56-1 C32H42O8 = 554.68 5mg QQ客服:215959384
    印楝沙兰林; Salannin CFN91920 992-20-1 C34H44O9 = 596.71 5mg QQ客服:1413575084
    Ohchinin; Ohchinin CFN97704 67023-80-7 C36H42O8 = 602.73 5mg QQ客服:215959384
    Ohchinin acetate; Ohchinin acetate CFN97143 67023-81-8 C38H44O9 = 644.8 5mg QQ客服:215959384
    1-Deacetylnimbolinin B; 1-Deacetylnimbolinin B CFN97244 76689-98-0 C33H44O9 = 584.7 5mg QQ客服:2159513211

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