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  • 山奈酚-3-O-芸香糖苷

    Nicotiflorin

    山奈酚-3-O-芸香糖苷
    产品编号 CFN99830
    CAS编号 17650-84-9
    分子式 = 分子量 C27H30O15 = 594.5
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Carthamus tinctorius L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    山奈酚-3-O-芸香糖苷 CFN99830 17650-84-9 10mg QQ客服:2056216494
    山奈酚-3-O-芸香糖苷 CFN99830 17650-84-9 20mg QQ客服:2056216494
    山奈酚-3-O-芸香糖苷 CFN99830 17650-84-9 50mg QQ客服:2056216494
    山奈酚-3-O-芸香糖苷 CFN99830 17650-84-9 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Chulalongkorn University (Thailand)
  • Sant Gadge Baba Amravati University (India)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • The University of Newcastle (Australia)
  • Gyeongsang National University (Korea)
  • University of Medicine and Pharmacy (Romania)
  • Lund University (Sweden)
  • Calcutta University (India)
  • Florida A&M University (USA)
  • National Hellenic Research Foundation (Greece)
  • University of Toronto (Canada)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Universiti Malaysia Pahang (Malaysia)
  • Almansora University (Egypt)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Green Chemistry2021, ISSUE 2.
  • Int J Mol Sci.2022, 23(21):12816.
  • BioResources J.2020, 15(3).
  • Int J Mol Sci.2021, 22(10):5181.
  • J Basic Clin Physiol Pharmacol.2016, 27(1):1-8
  • Acta horticulturae2017, 1158:257-268
  • Front Pharmacol.2018, 9:756
  • Horticulturae2023, 9(2), 213.
  • Tea Res. Ins. Of China2017, 1-12
  • Crystals2020, 10(3), 206.
  • Food Sci Biotechnol.2023, 32(9):1215-1223.
  • J Ethnopharmacol.2023, 321:117501.
  • Korean J. Medicinal Crop Sci.2021, 29(6):425-433
  • Molecules.2022, 27(19):6681.
  • Foods.2020, 9(10):1348.
  • The Japan Society for Analytical Chemistry2018, 67(4):201-206
  • Food Funct.2022, 13(23):12105-12120.
  • Mol Cell.2017, 68(4):673-685
  • Plant Direct.2021, 5(4):e00318.
  • Chem. of Vegetable Raw Materials2020, 97-105
  • Tropical J. of Pha. Research2017, 16(3):543-552
  • Natural Product Communications2021, 16(9):1-10.
  • Nutrients.2020, 12(3):595.
  • ...
  • 生物活性
    Description: Nicotiflorin shows potent antiglycation activity and neuroprotection effects, it has protective effects on cerebral ischemic damage, reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats.
    Targets: NOS | ATPase | Calcium Channel | Potassium Channel
    In vitro:
    Plant Physiol Biochem. 2012 Aug;57:23-31.
    Nicotiflorin, rutin and chlorogenic acid: phenylpropanoids involved differently in quantitative resistance of potato tubers to biotrophic and necrotrophic pathogens.[Pubmed: 22677447]
    Physiological and molecular mechanisms underlying quantitative resistance of plants to pathogens are still poorly understood, but could depend upon differences in the intensity or timing of general defense responses.
    METHODS AND RESULTS:
    This may be the case for the biosynthesis of phenolics which are known to increase after elicitation by pathogens. We thus tested the hypothesis that differences in quantitative resistance were related to differential induction of phenolics by pathogen-derived elicitors. Five potato cultivars (Solanum tuberosum, L.) spanning a range of quantitative resistance were treated with a concentrated culture filtrate (CCF) of Phytophthora infestans or purified lipopolysaccharides (LPS) from Pectobacterium atrosepticum. The kinetic of phenolics accumulation was followed and a set of typical phenolics was identified: chlorogenic acid, phenolamides and flavonols including rutin (quercetin-3-O-rutinoside) and Nicotiflorin (kaempferol-3-O-rutinoside). Our results showed that CCF but not LPS induced differential accumulation of major phenolics among cultivars. Total phenolics were related with resistance to P. atrosepticum but not to P. infestans. However, Nicotiflorin was inversely related with resistance to both pathogens. Rutin, but not Nicotiflorin, inhibited pathogen growth in vitro at physiological concentrations.
    CONCLUSIONS:
    These data therefore suggest that (i) several phenolics are candidate markers for quantitative resistance in potato, (ii) some of these are pathogen specific although they are produced by a general defense pathway, (iii) resistance marker molecules do not necessarily have antimicrobial activity, and (iv) the final content of these target molecules-either constitutive or induced-is a better predictor of resistance than their inducibility by pathogen elicitors.
    In vivo:
    Pharmacol Biochem Behav. 2007 Apr;86(4):741-8.
    Protective effects of Nicotiflorin on reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats.[Pubmed: 17448528]
    The present study aimed to determine whether Nicotiflorin, a natural flavonoid extracted from coronal of Carthamus tinctorius, has a protective effect on cerebral multi-infarct dementia in rats.
    METHODS AND RESULTS:
    The multi-infarct dementia model rats were prepared by injecting man-made micro-thrombi into the right hemisphere. The administration groups were treated once daily with 30, 60 and 120 mg/kg Nicotiflorin (i.g.) from 5 days before ischemia operation to 3 days after the operation for biochemical examination, 10 days for Morris water maze study and morphological observations and 20 days for eight-arm radial maze task. 2,3,5-triphenyltetrazolium chloride (TTC) staining showed that infarct volume of each Nicotiflorin administration group was much smaller than that of vehicle-treated multi-infarct dementia group, and hematoxylin and eosin (HE) staining showed that histopathological abnormalities of each Nicotiflorin group were also much lighter than that of vehicle-treated multi-infarct dementia group. Each Nicotiflorin group showed much better spatial memory performance in Morris water maze tests and eight-arm radial maze task compared with the vehicle-treated multi-infarct dementia group, significantly attenuated the elevation of lactic acid and malondialdehyde (MDA) contents and the decrease in lactate dehydrogenase (LDH), Na(+)K(+)ATPase, Ca(2+)Mg(2+)ATPase and superoxide dismutase (SOD) activity in the brain tissue which was composed of striatum, cortex and hippocampus of the ischemia hemisphere at day 3 after ischemia operation.
    CONCLUSIONS:
    These results suggest that Nicotiflorin has protective effects on reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6821 mL 8.4104 mL 16.8209 mL 33.6417 mL 42.0521 mL
    5 mM 0.3364 mL 1.6821 mL 3.3642 mL 6.7283 mL 8.4104 mL
    10 mM 0.1682 mL 0.841 mL 1.6821 mL 3.3642 mL 4.2052 mL
    50 mM 0.0336 mL 0.1682 mL 0.3364 mL 0.6728 mL 0.841 mL
    100 mM 0.0168 mL 0.0841 mL 0.1682 mL 0.3364 mL 0.4205 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Kaempferol 3-O-rhamninoside; Kaempferol 3-O-rhamninoside CFN96532 83170-31-4 C33H40O19 = 740.66 5mg QQ客服:1413575084
    鼠李柠檬素-3-O-β-D-葡萄糖苷; Rhamnocitrin 3-glucoside CFN95134 41545-37-3 C22H22O11 = 462.4 10mg QQ客服:3257982914
    鼠李柠檬素 3-O-半乳糖苷; Rhamnocitrin 3-galactoside CFN95474 99878-05-4 C22H22O11 = 462.4 10mg QQ客服:215959384
    氧氟草苷D; Oxytroflavoside D CFN95491 1391144-83-4 C28H30O15 = 606.5 10mg QQ客服:215959384
    鼠李柠檬素 3-O-beta-D-鼠李三糖苷; Catharticin CFN96538 39723-40-5 C34H42O19 = 754.69 5mg QQ客服:3257982914
    氧氟草苷F; Oxytroflavoside F CFN95489 1391144-85-6 C28H32O15 = 608.6 5mg QQ客服:2159513211
    堪非醇3-新橙皮糖苷; Kaempferol 3-neohesperidoside CFN98415 32602-81-6 C27H30O15 = 594.5 5mg QQ客服:2056216494
    山奈酚3-O-beta-D-槐糖苷; Kaempferol 3-O-beta-sophoroside CFN92372 19895-95-5 C27H30O16 = 610.5 20mg QQ客服:1457312923
    山奈酚3-O-洋槐糖苷; Biorobin CFN97804 17297-56-2 C27H30O15 = 594.53 5mg QQ客服:1457312923
    达提斯根苷; Datiscin CFN70287 16310-92-2 C27H30O15 = 594.5 5mg QQ客服:215959384

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