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  • 柚皮苷查尔酮

    Naringenin chalcone

    柚皮苷查尔酮
    产品编号 CFN90606
    CAS编号 73692-50-9
    分子式 = 分子量 C15H12O5 = 272.25
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Chalcones
    植物来源 The peels of Citrus maxima.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    柚皮苷查尔酮 CFN90606 73692-50-9 10mg QQ客服:1413575084
    柚皮苷查尔酮 CFN90606 73692-50-9 20mg QQ客服:1413575084
    柚皮苷查尔酮 CFN90606 73692-50-9 50mg QQ客服:1413575084
    柚皮苷查尔酮 CFN90606 73692-50-9 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Vigo (Spain)
  • Michigan State University (USA)
  • Nanjing University of Chinese Medicine (China)
  • Biotech R&D Institute (USA)
  • Lund University (Sweden)
  • Chinese University of Hong Kong (China)
  • University of Mysore (India)
  • Monash University Sunway Campus (Malaysia)
  • Universiti Sains Malaysia (Malaysia)
  • Osmania University (India)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Ain Shams University (Egypt)
  • University of Hawaii Cancer Center (USA)
  • University of Helsinki (Finland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Mol Pharm.2018, 15(8):3285-3296
  • Ind. J. Pharm. Edu. Res.2023; 57(3):1132-1139.
  • J Pharm Biomed Anal.2021, 196:113931.
  • Eur Endod J.2020, 5(1):23-27.
  • Br J Pharmacol.2020, 10.1111
  • bioRxiv2021, 458409.
  • Planta Med.2018, 84(6-07):465-474
  • Institute of Food Science & Technology2021, 56(11).
  • Antioxidants.2022, 11(3):491.
  • J Mol Med (Berl).2018, 96(7):661-672
  • Front Aging Neurosci.2019, 11:230
  • Cells.2022, 11(8), 1311.
  • J Ethnopharmacol.2022, 289:115018.
  • Phytomedicine Plus2022, 2(1):100207.
  • Food Bioscience2022, 50:102187.
  • J Chromatogr Sci.2020, 58(6):485-493.
  • Yakugaku Zasshi.2018, 138(4):571-579
  • Phytother Res.2019, 33(7):1784-1793
  • Mol Cells.2015, 38(9):765-72
  • J Biosci.2020, 45:46.
  • Molecules.2019, 24(4):E744
  • Nat Prod Commun.2018, 10.1177
  • Molecules.2021, 26(4):1084.
  • ...
  • 生物活性
    Description: Naringenin chalcone has antiallergic, anti-inflammatory ,and anti-asthmatic properties, it inhibits the production of proinflammatory cytokines in the interaction between adipocytes and macrophages, and improves adipocyte metabolic functions and exerts insulin-sensitizing effects by activating an adiponectin-related pathway.
    Targets: gp120/CD4 | TNF-α | NO | MCP-1 | Th2
    In vitro:
    Mol Cell Endocrinol. 2010 Jul 29;323(2):208-14.
    Naringenin chalcone improves adipocyte functions by enhancing adiponectin production.[Pubmed: 20363289]
    Naringenin chalcone is a flavonoid contained in tomato peel.
    METHODS AND RESULTS:
    In this study, we investigated its effects on adipocyte functions related to metabolic processes, including adipocytokine production. Naringenin chalcone promoted the gene expression (8.0-fold, p<0.001) and protein secretion (2.2-fold, p<0.001) of adiponectin from 3T3-L1 adipocytes. Reporter gene assays revealed that naringenin enhanced the activity of peroxisome proliferator-activated receptor gamma. DNA microarray experiments and Gene Ontology analysis revealed that naringenin chalcone also up-regulated the genes associated with mitochondrial energy metabolism, reflecting its insulin-sensitizing effects. Conversely, genes in categories such as those for cell adhesion were down-regulated. The expression of one adiponectin receptor, AdipoR2, was also increased (1.8-fold, p<0.01), suggesting that naringenin chalcone could activate the adiponectin pathway through the elevation of both the ligand and its receptor.
    CONCLUSIONS:
    These results indicate that naringenin chalcone is a potent tomato flavonoid that improves adipocyte metabolic functions and exerts insulin-sensitizing effects by activating an adiponectin-related pathway.
    Life Sci. 2007 Sep 29;81(16):1272-9.
    Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages.[Pubmed: 17915259]
    Obese adipose tissue is characterized by an enhanced infiltration of macrophages. It is considered that the paracrine loop involving monocyte chemoattractant protein (MCP)-1 and tumor necrosis factor (TNF)-alpha between adipocytes and macrophages establishes a vicious cycle that augments the inflammatory changes and insulin resistance in obese adipose tissue. Polyphenols, which are widely distributed in fruit and vegetables, can act as antioxidants and some of them are also reported to have anti-inflammatory properties. Tomato is one of the most popular and extensively consumed vegetable crops worldwide, which also contains many flavonoids, mainly naringenin chalcone.
    METHODS AND RESULTS:
    We investigated the effect of flavonoids, including naringenin chalcone, on the production of proinflammatory mediators in lipopolysaccharide (LPS)-stimulated macrophages and in the interaction between adipocytes and macrophages. Naringenin chalcone inhibited the production of TNF-alpha, MCP-1, and nitric oxide (NO) by LPS-stimulated RAW 264 macrophages in a dose-dependent manner. Coculture of 3T3-L1 adipocytes and RAW 264 macrophages markedly enhanced the production of TNF-alpha, MCP-1, and NO compared with the control cultures; however, treatment with naringenin chalcone dose-dependently inhibited the production of these proinflammatory mediators.
    CONCLUSIONS:
    These results indicate that naringenin chalcone exhibits anti-inflammatory properties by inhibiting the production of proinflammatory cytokines in the interaction between adipocytes and macrophages. Naringenin chalcone may be useful for ameliorating the inflammatory changes in obese adipose tissue.
    J Nat Prod . 2019 Feb 22;82(2):177-182.
    In Vivo Anti-inflammatory and Antiallergic Activity of Pure Naringenin, Naringenin Chalcone, and Quercetin in Mice[Pubmed: 30688453]
    Abstract Flavonoids, found in almost all fruits and vegetables, belong to a class of plant secondary metabolites with a polyphenolic structure and have properties with health-improving potential. However, few experimental studies on the effects of flavonoids have been carried out in vivo after external application and using pure compounds. Aiming to fill this gap, in this study we tested the topical anti-inflammatory and antiallergic activity of three flavonoids of high purity, naringenin, naringenin chalcone, and quercetin, in mouse models. The topical anti-inflammatory effects were assessed against arachidonic acid- (AA) and tetradecanoylphorbol-13-acetate- (TPA) induced ear edema. The anti-inflammatory effect of naringenin against ear edema was noticeable at a 1% dose in the AA model and at half this dose in the TPA model. Quercetin (1.3%) did not exert any topical anti-inflammatory activity in the AA model, but its inhibitory effect in the TPA model was similar to that of naringenin (2%); in contrast, naringenin chalcone was more active against the AA-induced than TPA-induced inflammation. The flavonoid effect on IgE-mediated passive cutaneous anaphylaxis was also studied in mice, both intravenously and topically. Naringenin, naringenin chalcone, and quercetin all showed strong antiallergic activity after intravenous dosing (0.02%) and when applied topically (2%). The results of this study suggest that the flavonoids naringenin, naringenin chalcone, and quercetin may be useful alternatives for the topical treatment of inflammatory and allergic skin disorders.
    In vivo:
    J Agric Food Chem. 2009 Jul 22;57(14):6432-7.
    Identification and quantification of metabolites of orally administered naringenin chalcone in rats.[Pubmed: 19558184]
    Naringenin chalcone is the main active component of tomato skin extract, which has an antiallergic activity.
    METHODS AND RESULTS:
    In this study, Naringenin chalcone was orally administered to rats, and the chemical structures and levels of the major metabolites in the plasma and urine of rats were determined. HPLC analysis indicated the presence of three major metabolites in the urine. LC-MS and NMR analyses tentatively identified these as Naringenin chalcone-2'-O-beta-D-glucuronide, naringenin-7-O-beta-D-glucuronide, and naringenin-4'-O-beta-D-glucuronide. Naringenin chalcone-2'-O-beta-D-glucuronide was the only metabolite detected in the plasma, and its peak plasma level was observed 1 h after Naringenin chalcone administration. Naringenin chalcone-2'-O-beta-D-glucuronide also inhibited histamine release from rat peritoneal mast cells stimulated with compound 48/80.
    CONCLUSIONS:
    This activity might contribute to the antiallergic activity of Naringenin chalcone in vivo. To the best of the authors' knowledge, this study is the first to report determination of Naringenin chalcone metabolites in rat plasma and urine.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.6731 mL 18.3655 mL 36.7309 mL 73.4619 mL 91.8274 mL
    5 mM 0.7346 mL 3.6731 mL 7.3462 mL 14.6924 mL 18.3655 mL
    10 mM 0.3673 mL 1.8365 mL 3.6731 mL 7.3462 mL 9.1827 mL
    50 mM 0.0735 mL 0.3673 mL 0.7346 mL 1.4692 mL 1.8365 mL
    100 mM 0.0367 mL 0.1837 mL 0.3673 mL 0.7346 mL 0.9183 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    龙血素D; Loureirin D CFN92676 119425-91-1 C16H16O5 = 288.3 10mg QQ客服:2159513211
    4,4'-二羟基-2,6-二甲氧基二氢查耳酮; 4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone CFN91700 151752-08-8 C17H18O5 = 302.3 5mg QQ客服:2056216494
    龙血素B; Loureirin B CFN98173 119425-90-0 C18H20O5 = 316.35 20mg QQ客服:2159513211
    2',4'-二氢查耳酮; 2',4'-Dihydroxydihydrochalcone CFN70401 53596-71-7 C15H14O3 = 242.3 20mg QQ客服:215959384
    4'-羟基查耳酮; 2-Benzal-4-hydroxyacetophenone CFN70089 2657-25-2 C15H12O2 = 224.2 20mg QQ客服:2056216494
    2',4'-二羟查耳酮; 2',4'-Dihydroxychalcone CFN95493 1776-30-3 C15H12O3 = 240.3 20mg QQ客服:3257982914
    3,4-二甲氧基查耳酮; 3,4-Dimethoxychalcone CFN70481 5416-71-7 C17H16O3 = 268.3 5mg QQ客服:2159513211
    紫铆因; Butein CFN98776 487-52-5 C15H12O5 = 272.3 20mg QQ客服:3257982914
    Homobutein; Homobutein CFN70340 34000-39-0 C16H14O5 = 286.3 5mg QQ客服:2056216494
    3,2',4'-三羟基-4-甲氧基查耳酮; 4-O-Methylbutein CFN96387 13323-67-6 C16H14O5 = 286.3 5mg QQ客服:215959384

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