N-Methyltaxol C

	产品编号	CFN89043
	CAS编号	153083-53-5
	分子式 = 分子量	C₄₇H₅₉NO₁₄ = 861.97
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The branches of Taxus Chinensis var.Mairei.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
N-Methyltaxol C	CFN89043	153083-53-5	1mg	QQ客服：3257982914
N-Methyltaxol C	CFN89043	153083-53-5	5mg	QQ客服：3257982914
N-Methyltaxol C	CFN89043	153083-53-5	10mg	QQ客服：3257982914
N-Methyltaxol C	CFN89043	153083-53-5	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Harvard University (USA)

Cancer Research Initatives Foundation(CARIF) (Malaysia)

Michigan State University (USA)

University of Wuerzburg (Germany)

Medical University of Gdansk (Poland)

Chungnam National University (Korea)

Monash University (Australia)

Cornell University (USA)

Chinese University of Hong Kong (China)

Amity University (India)

Deutsches Krebsforschungszentrum (Germany)

National Cancer Center Research Institute (Japan)

Universidade do Porto (Portugal)

University of Wollongong (Australia)

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Description:

N-methyltaxol C and paclitaxel can produce a positive inotropic effect in papillary muscle, without alterations in the action potential. They can induced conduction arrhythmias and reduce coronary flow and left ventricular systolic pressure in the isolated heart.

In vitro:

J Pharmacol Exp Ther. 1998 Feb;284(2):561-7.

Differential effects of paclitaxel and derivatives on guinea pig isolated heart and papillary muscle.[Pubmed: 9454798]

Paclitaxel (Taxol) is an anticancer agent with clinical activity against various human cancer types.
METHODS AND RESULTS:
Paclitaxel blocks cell division by stabilizing microtubules, a mechanism that also underlies its major side effects (neutropenia and neurotoxicity). Paclitaxel can also alter cardiac function, and to elucidate the mechanism of this activity, we tested the mechanical and electrical effects of paclitaxel and a series of analogs (docetaxel, taxol B, taxol C and N-Methyltaxol C; 5-20 microM) on two different cardiac preparations, the isolated coronary perfused heart and the papillary muscle of the guinea pig. Paclitaxel and N-Methyltaxol C induced conduction arrhythmias and reduced coronary flow and left ventricular systolic pressure in the isolated heart, whereas the other taxol derivatives tested had no significant effect. Moreover, paclitaxel blocked the vasodilator effect of bradykinin in the isolated heart. Paclitaxel and N-Methyltaxol C produced a positive inotropic effect in papillary muscle, without alterations in the action potential. In the latter preparation, no significant variations were observed after treatment with the other taxol derivatives.
CONCLUSIONS:
The in vitro cardiodepressant and arrhythmogenic activity of paclitaxel is similar to that reported after its clinical administration and might be due to coronary vasoconstriction. The precise role of microtubules as modulators of intracellular calcium in cardiac and smooth muscle cells is at present unclear, because docetaxel and other taxol analogs, though they exhibited similar activity on tubulin, lacked cardiac effects.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
10-去乙酰紫杉醇; Deacetyltaxol	CFN90687	78432-77-6	C₄₅H₄₉NO₁₃ = 811.87	20mg	QQ客服：215959384
7-表紫杉醇; 7-Epitaxol	CFN90371	105454-04-4	C₄₇H₅₁NO₁₄ = 853.91	20mg	QQ客服：215959384
紫杉醇; Paclitaxel	CFN97759	33069-62-4	C₄₇H₅₁NO₁₄ = 853.92	20mg	QQ客服：2159513211
7-木糖基-紫杉醇; 7-Xylosyltaxol	CFN98515	90332-66-4	C₅₂H₅₉NO₁₈ = 986.0	5mg	QQ客服：2056216494
7-木糖甙-10-脱乙酰基紫杉醇; 10-Deacetyl-7-xylosyl paclitaxel	CFN90837	90332-63-1	C₅₀H₅₇NO₁₇ = 944.0	20mg	QQ客服：2056216494
7-表-10-去乙酰紫杉醇; 7-Epi-10-deacetyltaxol	CFN89397	78454-17-8	C₄₅H₄₉NO₁₃ = 811.86	20mg	QQ客服：1457312923
7-Epi-10-deacetylcephalomannine ; 7-Epi-10-deacetylcephalomannine	CFN89395	78479-12-6	C₄₃H₅₁NO₁₃ = 789.86	5mg	QQ客服：1413575084
10-去乙酰三尖杉宁碱; 10-Deacetylcephalomannine	CFN95519	76429-85-1	C₄₃H₅₁NO₁₃ = 789.9	10mg	QQ客服：3257982914
7-木糖基-10-去乙酰基紫杉醇 B; 7-Xylosyl-10-deacetyltaxol B	CFN89389	90332-64-2	C₄₈H₅₉NO₁₇ = 921.97	20mg	QQ客服：2159513211
7-Xylosyltaxol B; 7-Xylosyltaxol B	CFN89398	90352-19-5	C₅₀H₆₁NO₁₈ = 964.01	5mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.1601 mL	5.8007 mL	11.6013 mL	23.2027 mL	29.0033 mL
5 mM	0.232 mL	1.1601 mL	2.3203 mL	4.6405 mL	5.8007 mL
10 mM	0.116 mL	0.5801 mL	1.1601 mL	2.3203 mL	2.9003 mL
50 mM	0.0232 mL	0.116 mL	0.232 mL	0.4641 mL	0.5801 mL
100 mM	0.0116 mL	0.058 mL	0.116 mL	0.232 mL	0.29 mL