桑辛素 D

Moracin D

	产品编号	CFN97179
	CAS编号	69120-07-6
	分子式 = 分子量	C₁₉H₁₆O₄ = 308.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The root barks of Morus alba L.
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产品名称	产品编号	CAS编号	包装	QQ客服
桑辛素 D	CFN97179	69120-07-6	1mg	QQ客服：2056216494
桑辛素 D	CFN97179	69120-07-6	5mg	QQ客服：2056216494
桑辛素 D	CFN97179	69120-07-6	10mg	QQ客服：2056216494
桑辛素 D	CFN97179	69120-07-6	20mg	QQ客服：2056216494

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Description:

Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization of Moracin may open a new avenue in the treatment of tumerigenesis.

Targets:

COX | c-Myc | TNF-α | Antifection

In vitro:

Molecules. 2011 Jul 19;16(7):6010-22.

Inhibitory effects of constituents from Morus alba var. multicaulis on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells.[Pubmed: 21772233]

METHODS AND RESULTS:
A new arylbenzofuran, 3',5'-dihydroxy-6-methoxy-7-prenyl-2-arylbenzofuran (1), and 25 known compounds, including moracin R (2), moracin C (3), moracin O (4), moracin P (5), artoindonesianin O (6), Moracin D (7), alabafuran A (8), mulberrofuran L (9), mulberrofuran Y (10), kuwanon A (11), kuwanon C (12), kuwanon T (13), morusin (14), kuwanon E (15), sanggenon F (16), betulinic acid (17), uvaol (18), ursolic acid (19), β-sitosterol (20), oxyresveratrol 2-O-β-D-glucopyranoside (21), mulberroside A (22), mulberroside B (23), 5,7-dihydroxycoumarin 7-O-β-D-glucopyranoside (24), 5,7-dihydroxycoumarin 7-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside (25) and adenosine (26), were isolated from Morus alba var. multicaulis Perro. (Moraceae). Their structures were determined by spectroscopic methods.
CONCLUSIONS:
The prenyl-flavonoids 11-14, 16, triterpenoids 17,18 and 20 showed significant inhibitory activity towards the differentiation of 3T3-L1 adipocytes. The arylbenzofurans 1-10 and prenyl-flavonoids 11-16 also showed significant nitric oxide (NO) production inhibitory effects in RAW264.7 cells.

In vivo:

Annals of Plant Sciences, 2013,2(10):412-9.

Effect of Moracin on DMBA-TPA induced skin cancer in the mice, Mus musculus (L).[Reference: WebLink]

The phytochemicals serves to orchestrate the healthy metabolism in the animal cells. The efforts in the study were conducted to assess the protective influence of Moracin, the major constituent of leaves of mulberry, Morus alba (L.) on tumor promotion in 7, 12 – dimethylbenz (alpha) anthracene (DMBA) – initiated and 12-O-tetradecanoylphorbol 13-acetate (TPA) – promoted mouse skin tumerigenesis model.
METHODS AND RESULTS:
The acetone solution of Moracin was topically applied to DMBA – initiated female mouse (Mus musculus) skin at the dosage of 2.5 and 5 mg twice per week for sixteen weeks, thirty minutes prior to each promotion treatment with TPA in the first experimental schedule. The significant reduction in tumor incidence and tumor multiplicity effects were evident in the treated group. The expression of tumor necrosis factor (TNF) – alpha protein and the level of 4-hydroxynoneal (4HNE) in the normal epidermis were significantly reduced in both moracin treated groups. Moracin at the dosage of 5 mg was topically applied to the dorsal surface of mouse skin 30 minutes before application of a TPA in the second effort in the study. And the same dosages of TPA and Moracin were applied twice at the interval of 24 hours. Moracin treatment was found inhibiting the double TPA treatment – induced morphological changes reflecting inflammatory response, including leucocyte infiltration, hyperplasia and cell proliferation. Moracin treatment furthermore significantly suppressed the elevation in 4-HNE level and elevated expression of c-fos, c-myc and cycloxygenase-2 (COX-2) in normal epidermis induced by double application of TPA.
CONCLUSIONS:
The moracin was found protective influence in tumor promotion. Utilization of Moracin may open a new avenue in the treatment of tumerigenesis.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
桑辛素 C; Moracin C	CFN97178	69120-06-5	C₁₉H₁₈O₄ = 310.4	5mg	QQ客服：2056216494
5-(6-羟基-2-苯并呋喃基)-2-[(1E)-3-甲基-1-丁烯-1-基]-1,3-苯二醇; 5-(6-Hydroxybenzofuran-2-yl)-2-(3-methylbut-1-enyl)benzene-1,3-diol	CFN97507	936006-11-0	C₁₉H₁₈O₄ = 310.4	5mg	QQ客服：2159513211
桑辛素 D; Moracin D	CFN97179	69120-07-6	C₁₉H₁₆O₄ = 308.3	5mg	QQ客服：2056216494
桑辛素 T; Moracin T	CFN92326	1146113-27-0	C₂₀H₂₀O₅ = 340.4	5mg	QQ客服：1413575084
桑辛素 P; Moracin P	CFN92324	102841-46-3	C₁₉H₁₈O₅ = 326.4	5mg	QQ客服：2159513211
桑皮苷C; Mulberroside C	CFN99587	102841-43-0	C₂₄H₂₆O₉ = 458.46	20mg	QQ客服：215959384
桑辛素 O; Moracin O	CFN96102	123702-97-6	C₁₉H₁₈O₅ = 326.4	5mg	QQ客服：1457312923
桑呋喃H; Mulberrofuran H	CFN92414	89199-99-5	C₂₇H₂₂O₆ = 442.5	5mg	QQ客服：215959384
大麻烯; Canniprene	CFN97198	70677-47-3	C₂₁H₂₆O₄ = 342.4	5mg	QQ客服：1457312923
4'-异戊烯基氧基白藜芦醇; 4'-Prenyloxyresveratrol	CFN90824	69065-16-3	C₁₉H₂₀O₄ = 312.4	10mg	QQ客服：1413575084

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2436 mL	16.218 mL	32.4359 mL	64.8719 mL	81.0898 mL
5 mM	0.6487 mL	3.2436 mL	6.4872 mL	12.9744 mL	16.218 mL
10 mM	0.3244 mL	1.6218 mL	3.2436 mL	6.4872 mL	8.109 mL
50 mM	0.0649 mL	0.3244 mL	0.6487 mL	1.2974 mL	1.6218 mL
100 mM	0.0324 mL	0.1622 mL	0.3244 mL	0.6487 mL	0.8109 mL

桑辛素 D

Moracin D

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