| In vitro: |
| Journal of Agricultural and Food Chemistry, 2013, 61(12):2979-2986. | | Antiproliferative and hypoglycemic cucurbitane-type glycosides from the fruits of Momordica charantia.[Pubmed: 23432055 ] |
METHODS AND RESULTS:
This paper reports that bioassay-guided fractionations of EtOH extract of Momordica charantia fruits led to the isolation of 15 cucurbitane-type triterpene glycosides including 4 new compounds, kuguaosides A-D (1-4), along with 11 known ones, charantoside A (5), momordicoside I (6), momordicoside F1 (7), momordicoside F2 (8), momordicoside K (9), momordicoside L (10), and momordicoside U (11), goyaglycosides-b (12) and -d (13), 7β,25-dihydroxycucurbita-5,23(E)-dien-19-al 3-O-β-d-allopyranoside (14), and 25-hydroxy-5β,19-epoxycucurbita-6,23-dien-19-on-3β-ol 3-O-β-d-glucopyranoside (15). Their structures were elucidated on the basis of spectroscopic analyses and chemical methods. This study also established the HPLC-ELSD fingerprinting profile of an antiproliferative fraction of which 11 main peaks were identified.
CONCLUSIONS:
Biological evaluation showed that several isolated cucurbitane-type triterpene glycosides had antiproliferative activities against MCF-7, WiDr, HEp-2, and Doay human tumor cell lines. In addition, compound 14 showed potent hypoglycemic activities by glucose uptake assay. |
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