罗汉果苷IVe

Mogroside IVe

	产品编号	CFN92189
	CAS编号	88915-64-4
	分子式 = 分子量	C₅₄H₉₂O₂₄ = 1125.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The fruits of Siraitia grosvenorii Swingle.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
罗汉果苷IVe	CFN92189	88915-64-4	1mg	QQ客服：215959384
罗汉果苷IVe	CFN92189	88915-64-4	5mg	QQ客服：215959384
罗汉果苷IVe	CFN92189	88915-64-4	10mg	QQ客服：215959384
罗汉果苷IVe	CFN92189	88915-64-4	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Bonn (Germany)

Complutense University of Madrid (Spain)

Imperial College London (United Kingdom)

Tokyo Woman's Christian University (Japan)

University of Illinois (USA)

Agricultural Research Organization (ARO) (Israel)

University of Cincinnati (USA)

University of Amsterdam (Netherlands)

Leibniz Institute of Plant Biochemistry (Germany)

University of Vigo (Spain)

University of Zurich (Switzerland)

Ain Shams University (Egypt)

Universidade Federal de Goias (UFG) (Brazil)

Universidad de La Salle (Mexico)

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Description:

Mogroside IVe can inhibit the proliferation of HT29 and Hep-2 cells in culture and in xenografted mice in a dose-dependent manner, which is accompanied by the upregulation of tumor suppressor p53, and downregulation of matrix metallopeptidase 9 (MMP-9) and phosphorylated extracellular signal-regulated kinases (ERK)1/2.

Targets:

p53 | ERK | MMP(e.g.TIMP)

In vitro:

Nutrients, 2016, 8(6):360.

Antiproliferative Activity of Triterpene Glycoside Nutrient from Monk Fruit in Colorectal Cancer and Throat Cancer[Pubmed: PMC4924201]

Colorectal cancer and throat cancer are the world’s most prevalent neoplastic diseases, and a serious threat to human health. Plant triterpene glycosides have demonstrated antitumor activity.
METHODS AND RESULTS:
In this study, we investigated potential anticancer effects of Mogroside IVe, a triterpenoid glycoside from monk fruit, using in vitro and in vivo models of colorectal and laryngeal cancer. The effects of Mogroside IVe on the proliferation of colorectal cancer HT29 cells and throat cancer Hep-2 cells were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and the expression levels of p53, phosphorylated ERK1/2, and MMP-9 were analyzed by western blotting and immunohistochemistry. The results indicated that Mogroside IVe inhibited, in a dose-dependent manner, the proliferation of HT29 and Hep-2 cells in culture and in xenografted mice, which was accompanied by the upregulation of tumor suppressor p53, and downregulation of matrix metallopeptidase 9 (MMP-9) and phosphorylated extracellular signal-regulated kinases (ERK)1/2.
CONCLUSIONS:
This study revealed the suppressive activity of Mogroside IVe towards colorectal and throat cancers and identified the underlying mechanisms, suggesting that Mogroside IVe may be potentially used as a biologically-active phytochemical supplement for treating colorectal and throat cancers.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
罗汉果苷VI; Mogroside VI	CFN90436	89590-98-7	C₆₆H₁₁₂O₃₄ = 1449.59	5mg	QQ客服：2159513211
罗汉果苷IIe; Mogroside IIe	CFN92191	88901-38-6	C₄₂H₇₂O₁₄ = 801.0	10mg	QQ客服：1413575084
罗汉果苷III; Mogroside III	CFN92190	130567-83-8	C₄₈H₈₂O₁₉ = 963.2	20mg	QQ客服：3257982914
11-O-罗汉果苷III; 11-Oxomogroside III	CFN92192	952481-53-7	C₄₈H₈₀O₁₉ = 961.2	10mg	QQ客服：2159513211
11-O-罗汉果苷IIIE; 11-Oxomogroside IIIE	CFN70309	2096516-68-4	C₄₈H₈₀O₁₉ = 961.2	10mg	QQ客服：2159513211
罗汉果皂苷II-A2; Mogroside II-A2	CFN92203	88901-45-5	C₄₂H₇₂O₁₄ = 801.0	10mg	QQ客服：215959384
11-氧-罗汉果皂苷IIA2; 11-Oxomogroside IIA2	CFN95305	2170761-37-0	C₄₂H₇₀O₁₄ = 799.0	5mg	QQ客服：3257982914
罗汉果苷IV; Mogroside IV	CFN90389	89590-95-4	C₅₄H₉₂O₂₄ = 1125.31	20mg	QQ客服：2159513211
11-O-罗汉果皂苷IV; 11-Oxomogroside IV	CFN91126	2096516-32-2	C₅₄H₉₀O₂₄ = 1123.3	5mg	QQ客服：215959384
罗汉果皂苷IVa; Mogroside IVa	CFN92188	88901-41-1	C₅₄H₉₂O₂₄ = 1125.3	10mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	0.8887 mL	4.4433 mL	8.8865 mL	17.773 mL	22.2163 mL
5 mM	0.1777 mL	0.8887 mL	1.7773 mL	3.5546 mL	4.4433 mL
10 mM	0.0889 mL	0.4443 mL	0.8887 mL	1.7773 mL	2.2216 mL
50 mM	0.0178 mL	0.0889 mL	0.1777 mL	0.3555 mL	0.4443 mL
100 mM	0.0089 mL	0.0444 mL	0.0889 mL	0.1777 mL	0.2222 mL