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  • 罗汉果皂苷IIIe

    Mogroside IIIe

    罗汉果皂苷IIIe
    产品编号 CFN92945
    CAS编号 88901-37-5
    分子式 = 分子量 C48H82O19 = 963.15
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruits of Siraitia grosvenorii Swingle.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    罗汉果皂苷IIIe CFN92945 88901-37-5 1mg QQ客服:2159513211
    罗汉果皂苷IIIe CFN92945 88901-37-5 5mg QQ客服:2159513211
    罗汉果皂苷IIIe CFN92945 88901-37-5 10mg QQ客服:2159513211
    罗汉果皂苷IIIe CFN92945 88901-37-5 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Regional Crop Research Institute (Korea)
  • Seoul National University of Science and Technology (Korea)
  • VIT University (India)
  • Subang Jaya Medical Centre (Malaysia)
  • MTT Agrifood Research Finland (Finland)
  • National Cancer Center Research Institute (Japan)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • University of Ioannina (Greece)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Universidad de Antioquia (Colombia)
  • Wroclaw Medical University (Poland)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Stanford University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2019, 24(21):E3834
  • Comp. & Mathematical Methods in Med.2022, 5475559.
  • Int J Mol Sci.2022, 23(10):5813.
  • UDC.2020, 19(4).
  • Reprod Sci.2022,10.1007/s43032-022-01117-4.
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • Toxicol In Vitro.2023, 86:105521.
  • Int J Biol Macromol.2019, 126:653-661
  • Anticancer Res.2018, 38(4):2127-2135
  • Oxid Med Cell Longev.2021, 2021:4883398.
  • iScience.2023, 26(9):107602.
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • J Food Biochem.2020, 44(6):e13198.
  • J Asian Nat Prod Res.2019, 5:1-17
  • J Pharmaceutical Research Int.2021, 33(41A):275-284.
  • J Korean Med Obes Res.2023, 23:10-7
  • Life (Basel).2022, 12(10):1630.
  • Molecules.2019, 24(4):E744
  • Food Bioscience2022, 50:102187.
  • Phytomedicine.2016, 23(4):331-9
  • Int J Mol Sci.2019, 20(3):E651
  • Oncology Letters2018, 4690-4696
  • J Nat Sc Biol Med2019, 10(2):149-156
  • ...
  • 生物活性
    Description: Mogroside IIIe has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF-κB axis via AMPK activation. It also has anti-fibrotic activity, it reduces pulmonary fibrosis through Toll-Like receptor 4 pathways.
    Targets: TNF-α | IL Receptor | TLR | MAPK | NF-kB | TGF-β/Smad
    In vivo:
    J Pharmacol Exp Ther. 2017 May;361(2):268-279.
    Mogroside IIIE, a Novel Anti-Fibrotic Compound, Reduces Pulmonary Fibrosis through Toll-Like Receptor 4 Pathways.[Pubmed: 28280123 ]
    Idiopathic pulmonary fibrosis is a progressive fibrotic lung disease, and eventually most patients develop respiratory failure with a median survival rate of 2 to 3 years after diagnosis due to the lack of clinically effective therapies. Mogroside IIIe (MGIIIE), a cucurbitane-type compound, was isolated from Siraitia grosvenorii MGIIIE has shown the strongest inhibition of nitric oxide release, a crucial inflammatory factor, from lipopolysaccharide (LPS)-treated RAW264.7 cells compared with other mogrosides.
    METHODS AND RESULTS:
    In the pulmonary fibrosis mouse model induced by bleomycin, MGIIIE treatment attenuated pulmonary fibrosis, indicated as a reduction in myeloperoxidase activity, collagen deposition, and pathologic score. MGIIIE also significantly suppressed expression of several important fibrotic markers, e.g., α-smooth muscle actin, collagen I, transforming growth factor-β (TGF-β) signal, and metalloproteinases-9/tissue inhibitor of metalloproteinase-1. Furthermore, MGIIIE blocked tansdifferentiation of lung resident fibroblasts into myofibroblast-like cells induced by TGF-β or LPS and subsequently inhibited collagen production in lung fibroblasts. These data indicate that MGIIIE is a potent inhibitor for pulmonary fibrosis. In vitro and in vivo mechanistic studies have shown that MGIIIE significantly decreased expression of toll-like receptor 4 (TLR4) and its downstream signals of myeloid differentiation factor 88 (MyD88)/mitogen-activated protein kinase (MAPK), an inflammatory signal essential for extracellular matrix (ECM) deposition in pulmonary fibroblasts.
    CONCLUSIONS:
    Taken together, these results demonstrate that MGIIIE significantly prevents pulmonary fibrosis by inhibiting pulmonary inflammation and ECM deposition through regulating TLR4/MyD88-MAPK signaling. Our study suggests that MGIIIE may have therapeutic potential for treating pulmonary fibrosis in clinical settings.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.0383 mL 5.1913 mL 10.3826 mL 20.7652 mL 25.9565 mL
    5 mM 0.2077 mL 1.0383 mL 2.0765 mL 4.153 mL 5.1913 mL
    10 mM 0.1038 mL 0.5191 mL 1.0383 mL 2.0765 mL 2.5956 mL
    50 mM 0.0208 mL 0.1038 mL 0.2077 mL 0.4153 mL 0.5191 mL
    100 mM 0.0104 mL 0.0519 mL 0.1038 mL 0.2077 mL 0.2596 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    罗汉果糖苷V; 罗汉果皂甙V; Mogroside V CFN99937 88901-36-4 C60H102O29 = 1287.44 20mg QQ客服:2159513211
    异-罗汉果皂苷V; Iso-mogroside V CFN92065 1126032-65-2 C60H102O29 = 1287.5 10mg QQ客服:215959384
    11-O-罗汉果苷V; 11-Oxo-mogroside V CFN90365 126105-11-1 C60H100O29 = 1285.42 20mg QQ客服:215959384
    11-去氧罗汉果苷V; 11-Deoxymogroside V CFN80166 1707161-17-8 C60H102O28 = 1271.44 10mg QQ客服:2056216494
    11-去氧异罗汉果苷V; 11-Deoxyisomogroside V CFN95288 1628293-32-2 C60H102O28 = 1271.5 10mg QQ客服:3257982914
    罗汉果苷VI; Mogroside VI CFN90436 89590-98-7 C66H112O34 = 1449.59 5mg QQ客服:2056216494
    罗汉果苷IIe; Mogroside IIe CFN92191 88901-38-6 C42H72O14 = 801.0 10mg QQ客服:3257982914
    罗汉果苷III; Mogroside III CFN92190 130567-83-8 C48H82O19 = 963.2 20mg QQ客服:1413575084
    11-O-罗汉果苷III; 11-Oxomogroside III CFN92192 952481-53-7 C48H80O19 = 961.2 10mg QQ客服:1413575084
    11-O-罗汉果苷IIIE; 11-Oxomogroside IIIE CFN70309 2096516-68-4 C48H80O19 = 961.2 10mg QQ客服:3257982914

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